A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection.


:We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a p value of 0.005. In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.


Microbes Infect


Microbes and infection


Biasin M,Sironi M,Saulle I,Pontremoli C,Garziano M,Cagliani R,Trabattoni D,Lo Caputo S,Vichi F,Mazzotta F,Forni D,Riva S,Aguilar-Jimenez W,Cedeño S,Sanchez J,Brander C,Zapata W,Rugeles MT,Clerici M




Has Abstract


2017-01-01 00:00:00














  • Establishment of a persistent mutant of canine distemper virus.

    abstract::We produced a B95a lymphoid cell line persistently infected with canine distemper virus (CDV), in which virus-specific antigens were present in nearly 100% of cells without causing cytopathic effect. The virus recovered from this cell line was able to infect fresh B95a cells persistently, indicating that a persistent ...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Iwatsuki K,Ikeda Y,Ohashi K,Nakamura K,Kai C

    更新日期:1999-10-01 00:00:00

  • Leukocyte-facilitated entry of intracellular pathogens into the central nervous system.

    abstract::Microbes use numerous strategies to invade the central nervous system. Leukocyte-facilitated entry is one such mechanism whereby intracellular pathogens establish infection by taking advantage of leukocyte trafficking to the central nervous system. Key components of this process include peripheral infection and activa...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Drevets DA,Leenen PJ

    更新日期:2000-11-01 00:00:00

  • Pathophysiological functions of the CagA oncoprotein during infection by Helicobacter pylori.

    abstract::Infection with Helicobacter pylori cagA-positive strains plays an essential role in the development of gastric carcinoma. This review summarizes the pathophysiological functions of the cagA gene product, CagA, particularly focusing on the molecular mechanisms underlying CagA translocation into the host cells as well a...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Murata-Kamiya N

    更新日期:2011-09-01 00:00:00

  • Epithelial entry rather than the ensuing systemic immune response determines the pathogenicity of two Salmonella enterica serovar Typhimurium strains in a mouse model.

    abstract::Most studies of Salmonella enterica serovar Typhimurium infection focus only on the pathogenicity of one strain. We investigated whether differences in pathogenicity of two wild-type S. Typhimurium strains; DT120 and SL1344, were related to gut invasion or the resulting immune response. Oral administration of a ten-fo...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Brandt R,Petersen A,Brix S,Licht TR,Frøkiær H

    更新日期:2013-11-01 00:00:00

  • Single amino acid substitutions on the needle tip protein IpaD increased Shigella virulence.

    abstract::Infection of colonic epithelial cells by Shigella is associated with the type III secretion system, which serves as a molecular syringe to inject effectors into host cells. This system includes an extracellular needle used as a conduit for secreted proteins. Two of these proteins, IpaB and IpaD, dock at the needle tip...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Meghraoui A,Schiavolin L,Allaoui A

    更新日期:2014-07-01 00:00:00

  • Bacillus thuringiensis pulmonary infection: critical role for bacterial membrane-damaging toxins and host neutrophils.

    abstract::The occurrence of Bacillus thuringiensis bacteremia in a neutropenic patient suffering from severe pulmonary disease addressed the question of whether the aggressive behavior of B. thuringiensis depended on the host status and/or on the membrane-damaging toxins the isolate produced. After intratracheal injection, BALB...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Ghelardi E,Celandroni F,Salvetti S,Fiscarelli E,Senesi S

    更新日期:2007-04-01 00:00:00

  • Zika virus: lessons learned in Brazil.

    abstract::Zika virus (ZIKV) greatly impacted the international scientific and public health communities in the last two years due to its association with microcephaly and other neonatal alterations. This review will discuss lessons learned from viral pathogenesis, epidemiology and clinical findings observed during the ZIKV outb...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Proenca-Modena JL,Milanez GP,Costa ML,Judice CC,Maranhão Costa FT

    更新日期:2018-12-01 00:00:00

  • B cell response during infection with the MAT a and MAT alpha mating types of Cryptococcus neoformans.

    abstract::In the present study, we compared the B cell response of BALB/c and C57Bl/6 mice during Cryptococcus neoformans infection. This response was investigated using virulent serotype D forms of mating types alpha and a (MAT alpha and MAT a). C57Bl/6 mice showed massive (mainly cerebral) infection by both types, while BALB/...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Rodrigues AR,Heise N,Previato JO,Mendonça-Previato L,Peçanha LM

    更新日期:2005-01-01 00:00:00

  • A rational strategy for a malarial vaccine development.

    abstract::Twenty years ago we reported the first synthetic peptide-based anti-malarial vaccine named SPf66, which conferred limited protective efficacy in large-scale human field-trials. Our efforts towards a second vaccine generation based on the rational selection of conserved high activity binding peptides (HABPs) whose crit...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Lozano JM,Patarroyo ME

    更新日期:2007-05-01 00:00:00

  • Host-microbe interplay in persistent Staphylococcus aureus nasal carriage in HIV patients.

    abstract::It has been shown that persistent Staphylococcus aureus nasal carriage results in increased bacterial dispersal and a higher risk of infection compared to non-or-intermittent S. aureus carriage. Although many studies investigated S. aureus nasal carriage in HIV patients, none compared persistent carriage to non-persis...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Melles DC,Pauw E,van den Boogaard L,Boelens HA,Peters J,Peeters JK,Witsenboer H,van Leeuwen WB,Verbrugh HA,van Belkum A,Nouwen JL

    更新日期:2008-02-01 00:00:00

  • Phospholipase B activity enhances adhesion of Cryptococcus neoformans to a human lung epithelial cell line.

    abstract::Secreted phospholipase B (PLB1), which contains three enzyme activities in the one protein, is necessary for the initiation of pulmonary infection by Cryptococcus neoformans and for dissemination from the lung via the lymphatics and blood. Adhesion to lung epithelium is the first step in this process, therefore we inv...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Ganendren R,Carter E,Sorrell T,Widmer F,Wright L

    更新日期:2006-04-01 00:00:00

  • Regulation between survival, persistence, and elimination of intracellular mycobacteria: a nested equilibrium of delicate balances.

    abstract::This review elaborates on recent insights gained on the dynamic aspects of interactions between pathogen and the host intracellular machinery in tuberculosis infection. In addition we will also discuss the utility of adopting a systems biology approach, both for a better understanding of TB biology, and for the develo...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Kumar D,Rao KV

    更新日期:2011-02-01 00:00:00

  • Characterization of apoptosis induced by sorbitol: a unique system for the detection of antiapoptotic activities of viruses.

    abstract::The treatment of HEp-2 cells with sorbitol induced massive apoptosis rapidly. This method for inducing apoptosis is very useful to detect antiapoptotic activity of viruses as well as viral genes. Commitment to death occurred immediately upon incubation with sorbitol, even in the presence of pancaspase inhibitor, Z-VAD...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Koyama AH,Arakawa T,Adachi A

    更新日期:2000-05-01 00:00:00

  • Oropouche fever, an emergent disease from the Americas.

    abstract::Oropouche virus is the aetiological agent of Oropouche fever, a zoonotic disease mainly transmitted by midges of the species Culicoides paraensis. Although the virus was discovered in 1955, more attention has been given recently to both the virus and the disease due to outbreaks of Oropouche fever in different areas o...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Romero-Alvarez D,Escobar LE

    更新日期:2018-03-01 00:00:00

  • Dengue virus infection-enhancing and neutralizing antibody balance in children of the Philippines and Indonesia.

    abstract::Dengue fever and dengue hemorrhagic fever are important diseases worldwide. Although antibody-dependent enhancement of infection has been proposed as a mechanism for increased disease severity, enhancing antibodies in endemic people have not been thoroughly investigated. Recently, we established a serological assay sy...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Yamanaka A,Tabuchi Y,Mulyatno KC,Susilowati H,Hendrianto E,Soegijanto S,Konishi E

    更新日期:2012-11-01 00:00:00

  • IRE1α mediates PKR activation in response to Chlamydia trachomatis infection.

    abstract::Protein kinase RNA activated (PKR) is a crucial mediator of anti-viral responses but is reported to be activated by multiple non-viral stimuli. However, mechanisms underlying PKR activation, particularly in response to bacterial infection, remain poorly understood. We have investigated mechanisms of PKR activation in ...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Webster SJ,Ellis L,O'Brien LM,Tyrrell B,Fitzmaurice TJ,Elder MJ,Clare S,Chee R,Gaston JS,Goodall JC

    更新日期:2016-07-01 00:00:00

  • Characterization of a locus encoding four paralogous outer membrane lipoproteins of Brachyspira hyodysenteriae.

    abstract::The identification of Brachyspira hyodysenteriae outer membrane proteins (OMPs) that may stimulate immunity to swine dysentery is important for vaccine development. We report here the analysis of a novel locus, blpGFEA, encoding four tandem paralogous proteins of approximately 30 kDa from B. hyodysenteriae. The four p...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Cullen PA,Coutts SA,Cordwell SJ,Bulach DM,Adler B

    更新日期:2003-04-01 00:00:00

  • Immunogenicity and structural characterisation of an in vitro folded meningococcal siderophore receptor (FrpB, FetA).

    abstract::The iron-limitation-inducible protein FrpB of Neisseria meningitidis is an outer-membrane-localized siderophore receptor. Because of its abundance and its capacity to elicit bactericidal antibodies, it is considered a vaccine candidate. Bactericidal antibodies against FrpB are, however, type-specific. Hence, an FrpB-b...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Kortekaas J,Müller SA,Ringler P,Gregorini M,Weynants VE,Rutten L,Bos MP,Tommassen J

    更新日期:2006-07-01 00:00:00

  • Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium.

    abstract::The inner ear has been regarded as an immunoprivileged site because of isolation by the blood-labyrinthine barrier. Several reports have indicated the existence of immune cells in the inner ear, but there are no reports showing immunocompetence of the cochlear tissue. In this report, we examined the potential involvem...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Hayashi Y,Onomoto K,Narita R,Yoneyama M,Kato H,Nakagawa T,Ito J,Taura A,Fujita T

    更新日期:2013-07-01 00:00:00

  • Malaria transmission-blocking vaccines: the bonus of effective malaria control.

    abstract::Reduction of transmission is important for effective malaria control. Standard microscopic detection grossly underestimates the human transmission reservoir. Malaria transmission intensity is defined by local and focal conditions. Transmission-blocking vaccines may be effective by directly targeting identified hot spo...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Sauerwein RW

    更新日期:2007-05-01 00:00:00

  • Thalidomide in the treatment of leprosy.

    abstract::Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflamma...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Teo S,Resztak KE,Scheffler MA,Kook KA,Zeldis JB,Stirling DI,Thomas SD

    更新日期:2002-09-01 00:00:00

  • The paralogous salivary anti-complement proteins IRAC I and IRAC II encoded by Ixodes ricinus ticks have broad and complementary inhibitory activities against the complement of different host species.

    abstract::Several observations suggest that inhibition of the host complement alternative pathway by Ixodes tick saliva is crucial to achieve blood feeding. We recently described two paralogous anti-complement proteins called Ixodes ricinus anti-complement (IRAC) proteins I and II co-expressed in I. ricinus salivary glands. Phy...

    journal_title:Microbes and infection

    pub_type: 信件


    authors: Schroeder H,Daix V,Gillet L,Renauld JC,Vanderplasschen A

    更新日期:2007-02-01 00:00:00

  • Dental screening of medical patients for oral infections and inflammation: consideration of risk and benefit.

    abstract::The primary purpose of preoperative dental screening of medical patients is to detect acute or chronic oral conditions that may require management prior to planned medical interventions. The aim of this communication is to discuss the background of preoperative dental screening and the link between dental pathologies ...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Maret D,Peters OA,Vigarios E,Epstein JB,van der Sluis L

    更新日期:2017-02-01 00:00:00

  • Lactobacilli in the intestinal microbiota of Swedish infants.

    abstract::Lactobacillus colonisation was examined in 112 Swedish infants. Faecal samples obtained at 1, 2, 4 and 8 weeks and at 6, 12 and 18 months of age were cultivated quantitatively on Rogosa agar. Lactobacilli were speciated by PCR and typed to the strain level by randomly amplified polymorphic DNA (RAPD). Lactobacilli rea...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Ahrné S,Lönnermark E,Wold AE,Aberg N,Hesselmar B,Saalman R,Strannegård IL,Molin G,Adlerberth I

    更新日期:2005-08-01 00:00:00

  • Pathogenic conversion of coagulase-negative staphylococci.

    abstract::Humans and animals are colonized by members of the genus Staphylococcus, however only some of these species evolved to cause invasive disease. The genetic basis for conversion of commensal staphylococci into pathogens is not known. We hypothesized that Staphylococcus aureus genes for coagulation and agglutination in v...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Yu W,Kim HK,Rauch S,Schneewind O,Missiakas D

    更新日期:2017-02-01 00:00:00

  • V beta profiles in African children with acute cerebral or uncomplicated malaria: very focused changes among a remarkable global stability.

    abstract::T cells are thought to play a critical role in cerebral malaria pathogenesis. However, available evidences are restricted to rodent models in which V beta specific T cell expansion has been associated with neurological syndrome suggesting involvement of superantigens or dominant antigens. Using flow cytometry, we stud...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Loizon S,Boeuf P,Tetteh JK,Goka B,Obeng-Adjei G,Kurtzhals JA,Rogier C,Akanmori BD,Mercereau-Puijalon O,Hviid L,Behr C

    更新日期:2007-09-01 00:00:00

  • Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex.

    abstract::Kinins, the vasoactive peptides proteolytically liberated from kininogens, were recently recognized as signals alerting the innate immune system. Here we demonstrate that Leishmania donovani and Leishmania chagasi, two etiological agents of visceral leishmaniasis (VL), activate the kinin system. Intravital microscopy ...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Svensjö E,Batista PR,Brodskyn CI,Silva R,Lima AP,Schmitz V,Saraiva E,Pesquero JB,Mori MA,Müller-Esterl W,Scharfstein J

    更新日期:2006-01-01 00:00:00

  • A randomized open-label clinical trial of an anti-HPV biological dressing (JB01-BD) administered intravaginally to treat high-risk HPV infection.

    abstract::Currently, there is no specific antiviral therapy for HPV infection. We conducted a randomized open-label clinical trial of JB01-BD, an anti-HPV biological dressing from Shanxi Jinbo Pharmaceutical Co., Ltd., China, for treatment of HPV infection. Seventy-seven women with cervical infection by high-risk HPV were rando...

    journal_title:Microbes and infection

    pub_type: 杂志文章,随机对照试验


    authors: Guo X,Qiu L,Wang Y,Wang Y,Wang Q,Song L,Li Y,Huang K,Du X,Fan W,Jiang S,Wang Q,Li H,Yang Y,Meng Y,Zhu Y,Lu L,Jiang S

    更新日期:2016-02-01 00:00:00

  • Virulence factors of schistosomes.

    abstract::This review considers whether the products of schistosomes in the mammalian host can be considered as virulence factors. These include: the cercarial secretions used in infection, those of the migrating schistosomulum, surface-exposed proteins of adult worms in the portal system and their gut vomitus in the context of...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Wilson RA

    更新日期:2012-12-01 00:00:00

  • The ASK1-MAP kinase pathways in immune and stress responses.

    abstract::Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate ...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Hayakawa T,Matsuzawa A,Noguchi T,Takeda K,Ichijo H

    更新日期:2006-04-01 00:00:00