Abstract：
:We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a p value of 0.005. In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Biasin M,Sironi M,Saulle I,Pontremoli C,Garziano M,Cagliani R,Trabattoni D,Lo Caputo S,Vichi F,Mazzotta F,Forni D,Riva S,Aguilar-Jimenez W,Cedeño S,Sanchez J,Brander C,Zapata W,Rugeles MT,Clerici Mdoi
10.1016/j.micinf.2016.09.005subject
Has Abstractpub_date
2017-01-01 00:00:00pages
69-74issue
1eissn
1286-4579issn
1769-714Xpii
S1286-4579(16)30132-0journal_volume
19pub_type
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journal_title：Microbes and infection
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pub_type： 杂志文章
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journal_title：Microbes and infection
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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pub_type： 信件
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journal_title：Microbes and infection
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journal_title：Microbes and infection
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