abstract：:The intestine is inhabited by a diverse range of microorganisms, which requires the host to employ numerous barrier measures to prevent bacterial invasion. However, the intestinal microbiota additionally acts symbiotically with host cells to maintain epithelial barrier function, and perturbation to this interaction pl...

journal_title：Microbes and infection

authors： Goyal S,Tsang DKL,Maisonneuve C,Girardin SE

更新日期：2020-11-12 00:00:00

abstract：:A psittacosis epidemic linked to fulmar hunting occurred on the Faroe Islands in the 1930s. This study investigates a plausible explanation to the 20% human mortality in this outbreak. Phylogenetic analysis showed that Chlamydia psittaci isolated from fulmars were closely related to the highly virulent 6BC strains fro...

journal_title：Microbes and infection

authors： Wang H,Jensen JK,Olsson A,Vorimore F,Aaziz R,Guy L,Ellström P,Laroucau K,Herrmann B

更新日期：2020-09-01 00:00:00

abstract：:Coxiella burnetii is an intracellular bacterium that causes acute and chronic Q fever. This unique pathogen has been historically challenging to study due to obstacles in genetically manipulating the organism and the inability of small animal models to fully mimic human Q fever. Here, we review the current state of C....

journal_title：Microbes and infection

authors： Dragan AL,Voth DE

更新日期：2020-04-01 00:00:00

abstract：:Parasites of the genus Schistosoma are organisms capable of living for decades within the definitive host. They interfere with the immune response by interacting with host's receptors. In this review, we discuss from the first reports to the most recent discoveries regarding the ability of Schistosoma antigens in trig...

journal_title：Microbes and infection

authors： Sanches RCO,Souza C,Oliveira SC

更新日期：2020-01-01 00:00:00

abstract：:Novel coronavirus disease 2019 (COVID-19) pandemic is the most recent health care crisis without specific prophylactic or therapeutic drugs. Antimalarial drug chloroquine (CHL) and its safer derivative hydroxychloroquine (HCHL) have been proposed to be repurposed to treat SARS coronavirus-2 (SARS-CoV-2), the causative...

journal_title：Microbes and infection

authors： Sharma A

更新日期：2020-01-01 00:00:00

abstract：:Absent in melanoma 2 (AIM2) is a sensor of cytosolic dsDNA and is responsible for the activation of inflammatory and host immune responses to DNA viruses and intracellular bacteria. AIM2 is a member of the hematopoietic interferon-inducible nuclear proteins with a 200 amino-acid repeat (HIN200) family, containing a py...

journal_title：Microbes and infection

authors： Costa Franco MMS,Marim FM,Alves-Silva J,Cerqueira D,Rungue M,Tavares IP,Oliveira SC

更新日期：2019-03-01 00:00:00

abstract：:About the relationship between retroviral genome packaging and translation, three possible modes (random-, trans-, and cis-) of packaging process could be assumed. In this report, we developed an assay system based on the RT-qPCR to measure the packaging efficiency of primate lentiviruses. With this system, we analyze...

journal_title：Microbes and infection

authors： Sakuragi S,Shioda T,Sakuragi JI

更新日期：2019-03-01 00:00:00

abstract：:The Mycobacterium abscessus complex can cause fatal pulmonary disease, especially in cystic fibrosis patients. Diagnosing M. abscessus complex pulmonary disease is challenging. Immunologic assays specific for M. abscessus are not available. In this study seven clinical M. abscessus complex strains and the M. abscessus...

journal_title：Microbes and infection

authors： Steindor M,Nkwouano V,Stefanski A,Stuehler K,Ioerger TR,Bogumil D,Jacobsen M,Mackenzie CR,Kalscheuer R

更新日期：2019-01-01 00:00:00

abstract：:Several pathogens including Gram-negative bacteria hijack complement regulators to escape host's innate response. Pathogenic Leptospira species bind Factor H, C4b binding protein and vitronectin from the complement system. We evaluated the ability of low passage (LP) and culture-attenuated (CA) pathogenic strains of L...

journal_title：Microbes and infection

authors： Moreno-Torres A,Malvido-Jiménez IR,de la Peña-Moctezuma A,Castillo Sánchez LO,Fraga TR,Barbosa AS,Isaac L,Sahagún-Ruiz A

更新日期：2019-01-01 00:00:00

abstract：:Infection with Trypanosoma cruzi, the etiologic agent in Chagas disease, may result in heart disease. Over the last decades, Chagas disease endemic areas in Latin America have seen a dietary transition from the traditional regional diet to a Western style, fat rich diet. Previously, we demonstrated that during acute i...

journal_title：Microbes and infection

authors： Lizardo K,Ayyappan JP,Cui MH,Balasubramanya R,Jelicks LA,Nagajyothi JF

更新日期：2019-01-01 00:00:00

abstract：:Osteoarticular brucellosis is the most frequent complication of active disease. A large amount of cells in bone are osteocytes. Since bone remodeling process is regulated by hormones we sought to study the effect of cortisol and DHEA in Brucella abortus-infected osteocytes. Cortisol treatment inhibited the expression ...

journal_title：Microbes and infection

authors： Pesce Viglietti AI,Giambartolomei GH,Delpino MV

更新日期：2019-01-01 00:00:00

abstract：:Zika virus (ZIKV) greatly impacted the international scientific and public health communities in the last two years due to its association with microcephaly and other neonatal alterations. This review will discuss lessons learned from viral pathogenesis, epidemiology and clinical findings observed during the ZIKV outb...

journal_title：Microbes and infection

authors： Proenca-Modena JL,Milanez GP,Costa ML,Judice CC,Maranhão Costa FT

更新日期：2018-12-01 00:00:00

abstract：:The obligate intracellular bacterium Chlamydia trachomatis is the most common bacterial agent of sexually transmitted disease world-wide. Chlamydia trachomatis primarily infects epithelial cells of the genital tract but the infection may be associated with ascending infection. Infection-associated inflammation can cau...

journal_title：Microbes and infection

authors： Lehr S,Vier J,Häcker G,Kirschnek S

更新日期：2018-05-01 00:00:00

abstract：:Acanthamoeba isolated from environmental soil harbors the obligate intracellular symbiont Neochlamydia, which has a critical role in host amoebal defense against Legionella pneumophila infection. Here, by using morphological analysis with confocal laser scanning fluorescence microscopy and transmission electron micros...

journal_title：Microbes and infection

authors： Maita C,Matsushita M,Miyoshi M,Okubo T,Nakamura S,Matsuo J,Takemura M,Miyake M,Nagai H,Yamaguchi H

更新日期：2018-04-01 00:00:00

abstract：:Clinical metagenomics (CMg) refers to as the application of metagenomic sequencing of clinical samples in order to recover clinically-relevant information. Due to the increasing access to next-generation sequencing (NGS) facilities, CMg is a gast-growing field. In this context, we held the second International Confere...

journal_title：Microbes and infection

authors： Ruppé E,Schrenzel J

更新日期：2018-04-01 00:00:00

abstract：:We previously found that, in a mouse model of Chagas cardiomyopathy, 18% of the 9390 quantified unigenes were significantly regulated by Trypanosoma cruzi infection. However, treatment with bone marrow-derived mononuclear cells (MNCs) resulted in 84% transcriptomic recovery. We have applied new algorithms to reanalyze...

journal_title：Microbes and infection

authors： Iacobas DA,Iacobas S,Tanowitz HB,Campos de Carvalho A,Spray DC

更新日期：2018-03-01 00:00:00

abstract：:Oropouche virus is the aetiological agent of Oropouche fever, a zoonotic disease mainly transmitted by midges of the species Culicoides paraensis. Although the virus was discovered in 1955, more attention has been given recently to both the virus and the disease due to outbreaks of Oropouche fever in different areas o...

journal_title：Microbes and infection

authors： Romero-Alvarez D,Escobar LE

更新日期：2018-03-01 00:00:00

abstract：:Microsporidia are intracellular pathogens that cause severe disease in immunocompromised humans and animals. We recently demonstrated that XID mice are more susceptible to Encephalitozoon cuniculi infection by intraperitoneal route, evidencing the role of B-1 cells in resistance against infection. The present study in...

journal_title：Microbes and infection

authors： Langanke Dos Santos D,Alvares-Saraiva AM,Xavier JG,Spadacci-Morena DD,Peres GB,Dell'Armelina Rocha PR,Perez EC,Lallo MA

更新日期：2018-03-01 00:00:00

abstract：:Influenza A virus (IAV) is a pulmonary pathogen, responsible for significant yearly morbidity and mortality. Due to the absence of highly effective antiviral therapies and vaccine, as well as the constant threat of an emerging pandemic strain, there is considerable need to better understand the host-pathogen interacti...

journal_title：Microbes and infection

authors： Downey J,Pernet E,Coulombe F,Divangahi M

更新日期：2018-01-01 00:00:00

abstract：:Innate lymphoid cells (ILCs) are the innate counterpart of T cells. Upon infection or injury, ILCs react promptly to direct the developing immune response to the one most adapted to the threat facing the organism. Therefore, ILCs play an important role early in resistance to infection, but also to maintain homeostasis...

journal_title：Microbes and infection

authors： Cording S,Medvedovic J,Lecuyer E,Aychek T,Eberl G

更新日期：2018-01-01 00:00:00

abstract：:miRNAs are small noncoding RNA that play a crucial role in gene regulation by inhibiting translation or promoting mRNA degradation. Viruses themselves express miRNAs that can target either the host or viral mRNA transcriptome. Moreover, viral infection of cells causes a drastic change in host miRNAs. This complex inte...

journal_title：Microbes and infection

authors： Bhela S,Rouse BT

更新日期：2018-01-01 00:00:00

abstract：:In early 2014, a novel subclade (2.3.4.4) of the highly pathogenic avian influenza (HPAI) A(H5N8) virus caused the first outbreak in domestic ducks and migratory birds in South Korea. Since then, it has spread to 44 countries and regions. To date, no human infections with A(H5N8) virus have been reported, but the poss...

journal_title：Microbes and infection

authors： Xu W,Dai Y,Hua C,Wang Q,Zou P,Deng Q,Jiang S,Lu L

更新日期：2017-12-01 00:00:00

abstract：:Our previous study has demonstrated that IL-10 may modulate both indoleamine 2,3-dioxygenase (IDO) and CD163 expression in lepromatous leprosy (LL) cells, favoring Mycobacterium leprae persistence through induction of regulatory pathways and iron storage. Here, we observed that in LL lesion cells there is an increase ...

journal_title：Microbes and infection

authors： de Mattos Barbosa MG,da Silva Prata RB,Andrade PR,Ferreira H,de Andrade Silva BJ,da Paixão de Oliveira JA,Assis TQ,de Toledo-Pinto TG,de Lima Bezerra OC,da Costa Nery JA,Rosa PS,Bozza MT,Lara FA,Moraes MO,Schmitz V,Sarno EN

更新日期：2017-11-01 00:00:00

abstract：:Pneumococcal serine-rich repeat protein (PsrP) is a glycoprotein that mediates Streptococcus pneumoniae attachment to lung cells and promotes biofilm formation. Herein, we investigated the transcriptional organization of psrP-secY2A2, the 37-kbp pathogenicity island encoding PsrP and its accessory genes. PCR amplifica...

journal_title：Microbes and infection

authors： Lizcano A,Akula Suresh Babu R,Shenoy AT,Saville AM,Kumar N,D'Mello A,Hinojosa CA,Gilley RP,Segovia J,Mitchell TJ,Tettelin H,Orihuela CJ

更新日期：2017-06-01 00:00:00

abstract：:Humans and animals are colonized by members of the genus Staphylococcus, however only some of these species evolved to cause invasive disease. The genetic basis for conversion of commensal staphylococci into pathogens is not known. We hypothesized that Staphylococcus aureus genes for coagulation and agglutination in v...

journal_title：Microbes and infection

authors： Yu W,Kim HK,Rauch S,Schneewind O,Missiakas D

更新日期：2017-02-01 00:00:00

abstract：:The primary purpose of preoperative dental screening of medical patients is to detect acute or chronic oral conditions that may require management prior to planned medical interventions. The aim of this communication is to discuss the background of preoperative dental screening and the link between dental pathologies ...

journal_title：Microbes and infection

authors： Maret D,Peters OA,Vigarios E,Epstein JB,van der Sluis L

更新日期：2017-02-01 00:00:00

abstract：:Anti-retroviral therapy is useful to treat human immunodeficiency virus type 1 (HIV-1)-infected individuals, but has some major problems, such as the generation of multidrug-resistant viruses. To develop a novel supplemental or alternative therapeutic for CCR5-tropic (R5) HIV-1 infection, we generated a recombinant ve...

journal_title：Microbes and infection

authors： Okuma K,Fukagawa K,Kohma T,Takahama Y,Hamaguchi Y,Ito M,Tanaka Y,Buonocore L,Rose JK,Hamaguchi I

更新日期：2017-01-01 00:00:00

abstract：:The differential recognition of fungal cell wall polysaccharides that program innate and adaptive immunity to the human opportunistic fungal pathogen Aspergillus fumigatus has been a focus of considerable interest. In a mouse model of fungal conidia aspiration, decreased relative levels of cell wall core carbohydrates...

journal_title：Microbes and infection

authors： Amarsaikhan N,O'Dea EM,Tsoggerel A,Templeton SP

更新日期：2017-01-01 00:00:00

abstract：:Tissue Factor (TF) is the initiator of coagulation and Tissue Factor Inhibitor (TFPI) is the physiological inhibitor of the TF/FVIIa complex. Circulating levels of TF and TFPI were quantified in dengue patients and the relationships with disease severity and infecting serotype analysed. A significant decrease in TF an...

journal_title：Microbes and infection

authors： Leal de Azeredo E,Solórzano VE,de Oliveira DB,Marinho CF,de Souza LJ,da Cunha RV,Damasco PV,Kubelka CF,de-Oliveira-Pinto LM

更新日期：2017-01-01 00:00:00

abstract：:We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected s...

journal_title：Microbes and infection

authors： Biasin M,Sironi M,Saulle I,Pontremoli C,Garziano M,Cagliani R,Trabattoni D,Lo Caputo S,Vichi F,Mazzotta F,Forni D,Riva S,Aguilar-Jimenez W,Cedeño S,Sanchez J,Brander C,Zapata W,Rugeles MT,Clerici M

更新日期：2017-01-01 00:00:00

abstract：:The innate immune system detects the presence of microbes through different families of pattern-recognition receptors (PRRs). PRRs detect pathogens of all origins and trigger signaling events that activate innate and adaptive immunity. These events need to be tightly regulated in order to ensure optimal activation whe...

journal_title：Microbes and infection

authors： Odendall C,Kagan JC

更新日期：2017-01-01 00:00:00

abstract：:Several bacterial pathogens interact with their host through protein secretion effectuated by a type VI secretion system (T6SS). Francisella tularensis is a highly pathogenic intracellular bacterium that causes the disease tularemia. Proteins encoded by the Francisella pathogenicity island (FPI), which constitute a ty...

journal_title：Microbes and infection

authors： Ozanic M,Marecic V,Lindgren M,Sjöstedt A,Santic M

更新日期：2016-12-01 00:00:00

abstract：:Paracoccidioidomycosis is a systemic mycosis endemic to Latin America. The infection is initiated by inhalation of conidia into the lung and may develop as localized or disseminated disease depending on the depression of cellular immunity. In the present study, we observed that intratracheal infection with Paracoccidi...

journal_title：Microbes and infection

authors： Noal V,Santos S,Ferreira KS,Almeida SR

更新日期：2016-12-01 00:00:00

abstract：:Toxoplasma gondii can activate the nucleotide-binding domain and leucine-rich repeat-containing proteins NLRP1/3 inflammasomes, which mediate host resistance to the infection. Here we showed that deletion of mitogen-activated protein kinases MAPK1 and MAPK2 of type I parasite decreases acute virulence in mice, charact...

journal_title：Microbes and infection

authors： Wang S,Wang Z,Gu Y,Li Z,Li Z,Wei F,Liu Q

更新日期：2016-11-01 00:00:00

abstract：:Brucella abortus is an intracellular bacterium that establishes lifelong infections in livestock and humans although the mechanisms of its chronicity are poorly understood. Activated B cells have long lifespan and B. abortus infection activates B cells. Our results indicate that the direct infection of B cells with B....

journal_title：Microbes and infection

authors： Pesce Viglietti AI,Arriola Benitez PC,Giambartolomei GH,Delpino MV

更新日期：2016-09-01 00:00:00

abstract：:Recent studies have shown that infection with Porphyromonas gingivalis, a major periodontal pathogen, hastens the progression of non-alcoholic fatty liver disease (NAFLD). However, the intracellular fate of P. gingivalis in hepatocytes remains unknown. Here, using oleic-acid-induced HepG2 cells as an in vitro model fo...

journal_title：Microbes and infection

authors： Zaitsu Y,Iwatake M,Sato K,Tsukuba T

更新日期：2016-09-01 00:00:00

abstract：:Protein kinase RNA activated (PKR) is a crucial mediator of anti-viral responses but is reported to be activated by multiple non-viral stimuli. However, mechanisms underlying PKR activation, particularly in response to bacterial infection, remain poorly understood. We have investigated mechanisms of PKR activation in ...

journal_title：Microbes and infection

authors： Webster SJ,Ellis L,O'Brien LM,Tyrrell B,Fitzmaurice TJ,Elder MJ,Clare S,Chee R,Gaston JS,Goodall JC

更新日期：2016-07-01 00:00:00

abstract：:Control of human African trypanosomiasis (HAT) is highly dependent on the ability to detect and treat infected individuals. However, a number of individuals exposed to Trypanosoma brucei gambiense are able to control infection to undetectable levels in blood. They are long-term potential reservoirs and thus a threat f...

journal_title：Microbes and infection

authors： Ilboudo H,Jamonneau V,Koffi M,Kaboré J,Amoussa R,Holzmuller P,Garcia A,Bucheton B,Courtin D

更新日期：2016-06-01 00:00:00

abstract：:Mucosal epithelial cells express an autonomous innate immune response that controls the overgrowth of invaded bacteria, mitigates the harmful effects of the bacteria carried within, and does not rely on other external arms of the immune response. Epithelial cell autonomous innate immunity "respects" the social biology...

journal_title：Microbes and infection

authors： Ross KF,Herzberg MC

更新日期：2016-06-01 00:00:00

abstract：:Numerous Chlamydia trachomatis proteins have been identified as potential subunit vaccines, of which the major outer-membrane protein (MOMP) has, so far, proven the most efficacious. Recently, subunit A of the V-type ATP synthase (ATPase; TC0582) complex was shown to elicit partial protection against infection. Comput...

journal_title：Microbes and infection

authors： Tifrea DF,Barta ML,Pal S,Hefty PS,de la Maza LM

更新日期：2016-04-01 00:00:00