Abstract:
:Matrix metalloproteinases constitute a family of structurally related endopeptidases that are crucial for the normal turnover of the extracellular matrix. Elevated levels of MMP-9 have been demonstrated in synovial fluids of rheumatoid arthritis patients, and a correlation with the severity of the disease has been described. The aim of this study was to explore the impact of MMP-9 expression on joint inflammation and destruction in a model of bacterially induced septic arthritis. MMP-9 knock-out mice and C57Bl6 congenic controls were inoculated intravenously or intra-articularly with Staphylococcus aureus. Arthritis was evaluated clinically and by means of histology. Zymographic analyses were performed to study ex vivo induction of MMP-9 following exposure to S. aureus. The MMP-9 knock-out mice displayed a significantly higher frequency and severity, but not destructivity, of arthritis than did the wild-type mice. The knock-out mice also proved to harbour an increased number of bacteria locally in joints and systemically in kidneys, possibly by impaired extravasation and recruitment of leukocytes and a deficient early defence against infection. Our findings indicate that deficiency in MMP-9 increases the degree of joint inflammation due to decreased bacterial clearance.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Calander AM,Starckx S,Opdenakker G,Bergin P,Quiding-Järbrink M,Tarkowski Adoi
10.1016/j.micinf.2006.01.001subject
Has Abstractpub_date
2006-05-01 00:00:00pages
1434-9issue
6eissn
1286-4579issn
1769-714Xpii
S1286-4579(06)00055-4journal_volume
8pub_type
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