Thalidomide in the treatment of leprosy.

Abstract:

:Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflammatory cytokine TNF-alpha produced by monocytes.

journal_name

Microbes Infect

journal_title

Microbes and infection

authors

Teo S,Resztak KE,Scheffler MA,Kook KA,Zeldis JB,Stirling DI,Thomas SD

doi

10.1016/s1286-4579(02)01645-3

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

1193-202

issue

11

eissn

1286-4579

issn

1769-714X

pii

S1286457902016453

journal_volume

4

pub_type

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