Abstract:
:The enteropathogenic Escherichia coli (EPEC) effector protein EspG, like the Shigella effector VirA, functions through disruption of the host cell microtubule network. Reports have differed as to whether the EspG homologue, EspG2, is also responsible for microtubule disruption. In this study we show that following translocation, EspG2 and VirA are localised under adherent bacteria and able to restore the microtubule disruption phenotype to an espG/espG2 double EPEC mutant. The espG/espG2 double mutant produced A/E lesions similar to wild-type EPEC on human intestinal in vitro organ cultures. Determining the distribution of espG and espG2 among clinical EPEC isolates revealed two different types of espG (espG alpha and espG beta) and espG2 (intact and pseudo genes), which were associated with specific EPEC serotypes and closely followed the EPEC lineage. This investigation has established a role for EspG2 in the disruption of the microtubule network and associated different espG and espG2 types with different groups of EPEC.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Smollett K,Shaw RK,Garmendia J,Knutton S,Frankel Gdoi
10.1016/j.micinf.2006.04.004subject
Has Abstractpub_date
2006-07-01 00:00:00pages
2220-7issue
8eissn
1286-4579issn
1769-714Xpii
S1286-4579(06)00165-1journal_volume
8pub_type
杂志文章abstract::The virulence of Paracoccidioides brasiliensis can be attenuated or lost after long periods of repeated subculturing and reestablished after animal inoculation. Only one adhesin (gp43) has been described until now, among the various identified components of P. brasiliensis, and gp43 shows adhesion to laminin. Thus, th...
journal_title:Microbes and infection
pub_type: 杂志文章
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更新日期:2005-05-01 00:00:00
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journal_title:Microbes and infection
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doi:10.1016/j.micinf.2007.01.010
更新日期:2007-04-01 00:00:00
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journal_title:Microbes and infection
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2012.11.003
更新日期:2013-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
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更新日期:2001-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.12.002
更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s1286-4579(01)01504-0
更新日期:2002-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2010.07.016
更新日期:2010-12-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2017.11.004
更新日期:2018-03-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(99)80054-9
更新日期:1999-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2017.05.001
更新日期:2017-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2010.05.010
更新日期:2010-10-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2015.03.011
更新日期:2015-07-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.07.023
更新日期:2005-11-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/s1286-4579(00)01322-8
更新日期:2000-11-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2014.11.007
更新日期:2015-02-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/s1286-4579(99)80022-7
更新日期:1999-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/s1286-4579(00)00366-x
更新日期:2000-05-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2014.09.008
更新日期:2015-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/s1286-4579(00)00318-x
更新日期:2000-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2004.05.002
更新日期:2004-08-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2005.12.016
更新日期:2006-04-01 00:00:00
abstract::Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis (Pb), a thermal dimorphic fungus. Its major antigen is a 43-kDa glycoprotein. Gp43 embodies different functions: it participates in evasion mechanisms during the installation of primary infection, stimulates granul...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2008.10.011
更新日期:2009-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2010.03.006
更新日期:2010-07-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2011.01.005
更新日期:2011-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2012.10.007
更新日期:2013-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.02.007
更新日期:2005-05-01 00:00:00