Abstract:
:The treatment of HEp-2 cells with sorbitol induced massive apoptosis rapidly. This method for inducing apoptosis is very useful to detect antiapoptotic activity of viruses as well as viral genes. Commitment to death occurred immediately upon incubation with sorbitol, even in the presence of pancaspase inhibitor, Z-VAD-FMK. Apoptosis is also induced by other polyhydric alcohols with more than four hydroxyl groups, but not induced by glycerol or ethylene glycol. Sorbitol treatment on ice did not induce apoptosis either. These results suggest that this induction of apoptosis does not result simply from high osmotic pressure but probably by the interaction of solutes through their physical nature (such as hydrophobicity) with the plasma membrane of the cells.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Koyama AH,Arakawa T,Adachi Adoi
10.1016/s1286-4579(00)00366-xsubject
Has Abstractpub_date
2000-05-01 00:00:00pages
599-606issue
6eissn
1286-4579issn
1769-714Xpii
S1286-4579(00)00366-Xjournal_volume
2pub_type
杂志文章abstract::To investigate the association of viral infections with chronic fatigue syndrome (CFS), we assayed 2', 5'-oligoadenylate synthetase (2-5AS) activities in peripheral blood mononuclear cells from CFS patients in Japan. These patients were diagnosed in two hospitals, H1 and H2, located in different areas of the country. ...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2003.07.002
更新日期:2003-10-01 00:00:00
abstract::The primary purpose of preoperative dental screening of medical patients is to detect acute or chronic oral conditions that may require management prior to planned medical interventions. The aim of this communication is to discuss the background of preoperative dental screening and the link between dental pathologies ...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2016.10.002
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abstract::Yersiniabactin (Ybt) is a siderophore-dependent iron uptake system encoded on a pathogenicity island that is widespread among pathogenic bacteria including the Yersiniae. While biosynthesis of the siderophore has been elucidated, the secretion mechanism and a few components of the uptake/utilization pathway are uniden...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.11.011
更新日期:2006-04-01 00:00:00
abstract::Streptococcus pneumoniae is a major pathogen causing potentially life-threatening community-acquired diseases in both the developed and developing world. Since 1967, there has been a dramatic increase in the incidence of penicillin-resistant and multiply antibiotic-resistant pneumococci worldwide. Prevention of access...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(00)01345-9
更新日期:2000-12-01 00:00:00
abstract::This article explores one of a citation classics in medical literature-Koch's postulates. It analyses their creation in the nineteenth century and their popularity in the twentieth century. As a genre of historiography, references to the postulates are anecdotes. In referring to a historical event that never happened,...
journal_title:Microbes and infection
pub_type: 历史文章,杂志文章,评审
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更新日期:2014-11-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2007.01.010
更新日期:2007-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 信件
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更新日期:2020-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.12.003
更新日期:2007-03-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2004.12.018
更新日期:2005-04-01 00:00:00
abstract::Few human pathogens possess the ability exhibited by Candida albicans to colonize and cause symptomatic infections at different body sites. The host immune system is the major factor determining whether this opportunistic yeast behaves as a commensal or as a pathogen, since C. albicans strains appear capable of expres...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.09.016
更新日期:2006-03-01 00:00:00
abstract::Infectious diseases are major causes, with malignancies, of morbidity and mortality in the elderly. Increased susceptibility to infections may result from underlying dysfunction of an aged immune system; moreover, inappropriate immunologic functions associated with aging can determine an insufficient response to vacci...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(01)01443-5
更新日期:2001-08-01 00:00:00
abstract::Burkholderia pseudomallei is a major cause of bacterial septicemias in many parts of the world, particularly Thailand; the known geographic range of the organism appears to be enlarging as awareness of the organism and the disease it causes--melioidosis--increases. B. pseudomallei is intrinsically resistant to most an...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(99)80007-0
更新日期:1999-02-01 00:00:00
abstract::Porcine respiratory coronavirus (PRCV) potentiates respiratory disease and proinflammatory cytokine production in the lungs upon intratracheal inoculation with lipopolysaccharide (LPS) at 1 day of infection. This study aimed to quantify LPS-binding protein (LBP), CD14 and haptoglobin in the lungs throughout a PRCV inf...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.01.009
更新日期:2006-05-01 00:00:00
abstract::Following infection with Toxoplasma gondii, certain strains of mice, such as BALB/c, are genetically resistant to development of toxoplasmic encephalitis (TE) and establish a latent chronic infection as do humans. Thus, these animals appear to be a suitable model to analyze the mechanism of resistance to TE. Since the...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/s1286-4579(00)00318-x
更新日期:2000-04-01 00:00:00
abstract::Ebolavirus can cause a highly fatal and panic-generating human disease which may jump from bats to other mammals and human. High viral loads in body fluids allow efficient transmission by contact. Lack of effective antivirals, vaccines and public health infrastructures in parts of Africa make it difficult to health wo...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2014.11.007
更新日期:2015-02-01 00:00:00
abstract::Respiratory syncytial virus (RSV) infection causes severe lower respiratory diseases in infancy, early childhood and the elderly. RSV infections respond poorly to current therapies. Therefore, we initiated a search for novel drug targets by investigating the characteristics and identity of RSV adhesion receptors on ma...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/s1286-4579(02)00079-5
更新日期:2003-02-01 00:00:00
abstract::The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity. This report reviews our studies with Sylvio X10/4 parasites, a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to chronic myocarditis res...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2009.07.011
更新日期:2009-11-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2004.02.016
更新日期:2004-05-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.07.020
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2009.07.002
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2015.01.002
更新日期:2015-06-01 00:00:00
abstract::We previously showed the possibility that Gag A146P, which is an escape mutant from HLA-B∗57-restricted CTLs, was selected by HLA-B∗48:01-restricted Gag138-147(LI10)-specific CTLs in a Japanese cohort in which HLA-B∗57 individuals were not detected. We herein demonstrated Gag140-147(GI8) to be the optimal epitope rath...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2011.03.009
更新日期:2011-08-01 00:00:00
abstract::Acanthamoeba isolated from environmental soil harbors the obligate intracellular symbiont Neochlamydia, which has a critical role in host amoebal defense against Legionella pneumophila infection. Here, by using morphological analysis with confocal laser scanning fluorescence microscopy and transmission electron micros...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2017.12.012
更新日期:2018-04-01 00:00:00
abstract::Neisseria meningitidis is an opportunistic human pathogen that usually colonizes the nasopharyngeal mucosa asymptomatically. Upon invasion into the blood and central nervous system, this bacterium triggers a fulminant inflammatory reaction with the manifestations of septicemia and meningitis, causing high morbidity an...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2015.09.025
更新日期:2016-02-01 00:00:00
abstract::Helicobacter pylori infection induces chronic inflammation in the gastric mucosa with a marked increase in the number of lymphoid follicles consisting of infiltrating B and T cells, neutrophils, dendritic cells (DC) and macrophages. It has been suggested that an accumulation of mature DC in the tissue, resulting from ...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.10.007
更新日期:2006-03-01 00:00:00
abstract::In early 2014, a novel subclade (2.3.4.4) of the highly pathogenic avian influenza (HPAI) A(H5N8) virus caused the first outbreak in domestic ducks and migratory birds in South Korea. Since then, it has spread to 44 countries and regions. To date, no human infections with A(H5N8) virus have been reported, but the poss...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2017.08.006
更新日期:2017-12-01 00:00:00
abstract::The virulence of Paracoccidioides brasiliensis can be attenuated or lost after long periods of repeated subculturing and reestablished after animal inoculation. Only one adhesin (gp43) has been described until now, among the various identified components of P. brasiliensis, and gp43 shows adhesion to laminin. Thus, th...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.02.005
更新日期:2005-05-01 00:00:00
abstract::Brucella abortus is an intracellular bacterium that establishes lifelong infections in livestock and humans although the mechanisms of its chronicity are poorly understood. Activated B cells have long lifespan and B. abortus infection activates B cells. Our results indicate that the direct infection of B cells with B....
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2016.04.001
更新日期:2016-09-01 00:00:00
abstract::The Gram-negative bacterium Burkholderia cepacia has recently emerged as an important opportunistic pathogen in humans. This review focuses on the cellular aspects of B. cepacia infection and the dynamics of the B. cepacia-host cell interaction, including recent advances in our understanding of the ability of B. cepac...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(01)01389-2
更新日期:2001-04-01 00:00:00