Abstract：
:Microsporidia are intracellular pathogens that cause severe disease in immunocompromised humans and animals. We recently demonstrated that XID mice are more susceptible to Encephalitozoon cuniculi infection by intraperitoneal route, evidencing the role of B-1 cells in resistance against infection. The present study investigated the resistance and susceptibility against E. cuniculi oral infection, including the role of B-1 cells. BALB/c and BALB/c XID (B-1 cells deficient) mice were orally infected with E. cuniculi spores. No clinical symptoms were observed in infected animals; histopathology showed lymphoplasmocytic enteritis with degeneration of the apexes of the villi in all infected groups. Higher parasite burden was observed in infected BALB/c XID mice. In the spleen and peritoneum, all infected mice showed a decrease of lymphocytes, including CD8+ T cells, mostly in infected BALB/c XID mice. Adoptive transfer of B-1 cells (XID + B-1) was associated with a lower parasite burden. Pro-inflammatory cytokines (IFN-γ, TNF-α and IL-6) increased mostly in infected XID + B1 mice. Together, the present results showed that BALB/c XID mice infected by the oral route were more susceptible to encephalitozoonosis than BALB/c mice, demonstrating the B-1 cells importance in the control of the immune response against oral E. cuniculi infection.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Langanke Dos Santos D,Alvares-Saraiva AM,Xavier JG,Spadacci-Morena DD,Peres GB,Dell'Armelina Rocha PR,Perez EC,Lallo MAdoi
10.1016/j.micinf.2017.11.004subject
Has Abstractpub_date
2018-03-01 00:00:00pages
196-204issue
3eissn
1286-4579issn
1769-714Xpii
S1286-4579(17)30188-0journal_volume
20pub_type
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