Abstract:
:Evaluation of vector control is crucial for improving malaria containment and, according to World Health Organization, new complementary indicators would be very valuable. In this study the IgG response to the Anopheles-specific cE5 salivary protein was tested as a tool to evaluate the efficacy of insecticide-treated nets in reducing human exposure to malaria vectors. Sera collected during a longitudinal study carried out in Angola, and including entomological and parasitological data, were used to assess the IgG response to the Anopheles gambiae cE5 in both children and adults, before and after the application of insecticide-treated nets. Seasonal fluctuation of specific IgG antibody levels according to exposure was only found in children (up to ≈ 14 years old) whose anti-cE5 IgG response dropped after bed nets installation. These results were fully consistent with previous findings obtained with the same set of sera and indicating a substantial reduction of human-vector contact shortly after nets implementation. Overall, children IgG response to the cE5 protein appeared a very sensitive biomarker, which allowed for the detection of even weak exposure to Anopheles bites, indicating it may represent a reliable additional tool to evaluate the efficacy of vector control interventions.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Marie A,Ronca R,Poinsignon A,Lombardo F,Drame PM,Cornelie S,Besnard P,Le Mire J,Fiorentino G,Fortes F,Carnevale P,Remoue F,Arcà Bdoi
10.1016/j.micinf.2015.01.002subject
Has Abstractpub_date
2015-06-01 00:00:00pages
409-16issue
6eissn
1286-4579issn
1769-714Xpii
S1286-4579(15)00015-5journal_volume
17pub_type
杂志文章abstract::Motility is essential for Helicobacter pylori colonization. This review discusses the biochemistry, genetics and genomics of the H. pylori flagellum, and compares these features with well-characterized bacteria. ...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(00)01274-0
更新日期:2000-08-01 00:00:00
abstract::The systemic inflammatory response syndrome (SIRS) is the body's response to an infectious or noninfectious insult. Although the definition of SIRS refers to it as an "inflammatory" response, it actually has pro- and anti-inflammatory components. This review outlines the pathophysiology of SIRS and highlights potentia...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2005.12.016
更新日期:2006-04-01 00:00:00
abstract::We have previously reported that mice immunized with the mycobacterial 27-kDa lipoprotein were more susceptible to Mycobacterium tuberculosis (Mtb) challenge. We also showed that 27-kDa lipoprotein abrogated the protection afforded by the BCG vaccine when administrated together, suggesting that the 27-kDa lipoprotein ...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.02.011
更新日期:2006-06-01 00:00:00
abstract::AIDS patients frequently exhibit neurological disorders due to the neurotoxic events that result from HIV-1 and/or opportunistic infections in the brain. This review examines recent clinical findings related to HIV-1-associated dementia, and outlines current areas of basic research that may clarify how HIV-1-associate...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(02)01542-3
更新日期:2002-03-01 00:00:00
abstract::Cell-mediated immunity to Toxoplasma gondii establishes and maintains a balanced host-pathogen relationship. Recent analyses using spontaneous and genetically engineered mouse mutants have yielded a clearer picture of factors positively and negatively regulating the host immune response and a better understanding of c...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2005.10.031
更新日期:2006-04-01 00:00:00
abstract::Purging HIV-1 to cure the infection in patients undergoing suppressive antiretroviral therapy requires targeting all possible viral reservoirs. Other than the memory CD4(+) T cells, several other HIV-1 reservoirs have been identified. HIV-1 infection in the brain as a reservoir is well documented, but not fully charac...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2015.05.006
更新日期:2015-09-01 00:00:00
abstract::Denaturing high-performance liquid chromatography (DHPLC) is a relatively new technique, which utilizes heteroduplex formation between wild-type and mutated DNA strands to identify point mutations. Heteroduplex molecules are separated from homoduplex molecules by ion-pair, reverse-phase liquid chromatography on a spec...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.06.008
更新日期:2006-01-01 00:00:00
abstract::Novel vaccines are needed to control tuberculosis (TB), the bacterial infectious disease that together with malaria and HIV is worldwide responsible for high levels of morbidity and mortality. TB can result from the reactivation of an initially controlled latent infection by Mycobacterium tuberculosis (Mtb). Mtb prote...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2011.08.011
更新日期:2012-01-01 00:00:00
abstract::Control of human African trypanosomiasis (HAT) is highly dependent on the ability to detect and treat infected individuals. However, a number of individuals exposed to Trypanosoma brucei gambiense are able to control infection to undetectable levels in blood. They are long-term potential reservoirs and thus a threat f...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2016.03.002
更新日期:2016-06-01 00:00:00
abstract::Intracellular replication of Cryptosporidium parvum (Apicomplexa) involves the generation of several asexual and sexual forms of the parasite. During the stage conversions, complex mechanisms lead to differential structural and functional properties of the parasite. These require a well tuned gene transcription machin...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.04.012
更新日期:2006-07-01 00:00:00
abstract::Human histocompatibility leukocyte antigen (HLA)-G is an antigen-presenting molecule. This review discusses the possibility that this might not be its primary function. HLA-G indeed modulates innate immunity by interacting with immunoglobulin-like receptors and by regulating HLA-E expression and its subsequent interac...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(01)01386-7
更新日期:2001-04-01 00:00:00
abstract::Japanese encephalitis virus (JEV) is an arbovirus belonging to the family Flaviviridae. It is maintained in a zoonotic cycle involving pigs, ardeid birds and Culex species of mosquitoes. Humans are accidental/dead end hosts of JEV infection because they cannot sustain high viral titers. Factors affecting the clinical ...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2011.01.002
更新日期:2011-04-01 00:00:00
abstract::The bacterium Haemophilus ducreyi causes the sexually transmitted disease chancroid, which is characterized by the appearance of mucocutaneous, persistent ulcers on the external genitals. To identify carbohydrate receptors that mediate the attachment of this pathogen to host cells, we investigated the binding of 35S-m...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.05.009
更新日期:2006-08-01 00:00:00
abstract::Dengue fever and dengue hemorrhagic fever are important diseases worldwide. Although antibody-dependent enhancement of infection has been proposed as a mechanism for increased disease severity, enhancing antibodies in endemic people have not been thoroughly investigated. Recently, we established a serological assay sy...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2012.07.013
更新日期:2012-11-01 00:00:00
abstract::The manipulation hypothesis states a parasite may alter host behaviour for its own benefit, often by enhancing its transmission rate through the food chain. This paper reviews studies on the potential impact of one parasite, Toxoplasma gondii, on host behaviour, both on rodents, where altered responses may be proposed...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(01)01459-9
更新日期:2001-10-01 00:00:00
abstract::Exhaustive information on the Epstein-Barr virus, a member of the herpes family, is described at the International Herpes Management Forum web-site. Cervical cancer associations, AIDS treatment projects, and the Los Alamos National Laboratories provide useful information on papillomavirus infections, as well as hyperl...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/s1286-4579(00)01308-3
更新日期:2000-10-01 00:00:00
abstract::Long-term protection against Toxoplasma gondii is dependent on robust CD8(+) T cell immunity. In the absence of this response, the host is unable to maintain chronicity, which results in recrudescence of infection and possible death. Factors needed for the persistence of protective CD8(+) T cells against the parasite ...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2012.07.018
更新日期:2012-11-01 00:00:00
abstract::Viral protein R (Vpr), an accessory protein of human immunodeficiency virus type 1 (HIV-1), induces the G2 cell cycle arrest in fission yeast for which host factors, such as Wee1 and Rad24, are required. Catalyzing the inhibitory phosphorylation of Cdc2, Wee1 is known to serve as a major regulator of G2/M transition i...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.08.003
更新日期:2006-10-01 00:00:00
abstract::Burkholderia pseudomallei is a major cause of bacterial septicemias in many parts of the world, particularly Thailand; the known geographic range of the organism appears to be enlarging as awareness of the organism and the disease it causes--melioidosis--increases. B. pseudomallei is intrinsically resistant to most an...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(99)80007-0
更新日期:1999-02-01 00:00:00
abstract::CCR5-tropic (R5) immunodeficiency virus type 1 (HIV-1) strains are highly transmissible during the early stage of infection in humans, whereas CXCR4-tropic (X4) strains are less transmissible. This study aimed to explore the basis for early phase R5 and X4 HIV-1 infection in vivo by using humanized mice dually challen...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2015.02.002
更新日期:2015-05-01 00:00:00
abstract::Several pathogens including Gram-negative bacteria hijack complement regulators to escape host's innate response. Pathogenic Leptospira species bind Factor H, C4b binding protein and vitronectin from the complement system. We evaluated the ability of low passage (LP) and culture-attenuated (CA) pathogenic strains of L...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2019.03.001
更新日期:2019-01-01 00:00:00
abstract::The strategies used by bacterial pathogens to circumvent host defense mechanisms remain largely undefined in bivalve molluscs. In this study, we investigated experimentally the interactions between the Pacific oyster (Crassostrea gigas) immune system and Vibrio aestuarianus strain 01/32, a pathogenic bacterium origina...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.07.020
更新日期:2006-10-01 00:00:00
abstract::We analyzed the distribution and expression of cadherin and beta-catenin during Trypanosoma cruzi-cardiomyocyte interaction. Confocal microscopy revealed cadherin associated with beta-catenin at the cell-cell contacts. After 24h of infection, the spatial distribution and expression of both adherens junction (AJ) prote...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2008.07.044
更新日期:2008-10-01 00:00:00
abstract::Several glycoforms of CD43 are known to regulate cellular interactions in the immune system. One such glycoform, the CD43 that bears core 2 O-glycans, is also known to be expressed on T lymphocytes and natural killer cells, but only after their activation. Previous studies have also shown that when Caco-2 cells, which...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/s1286-4579(01)01431-9
更新日期:2001-07-01 00:00:00
abstract::The study established the virulence potential of multidrug-resistant Escherichia coli (MDREC) isolates from nosocomial infections in hospitalised dogs. The isolates were resistant to fluoroquinolones, belonged to two distinct clonal groups (CG1 and CG2) and contained a plasmid-mediated AmpC (CMY-7) beta-lactamase. CG1...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2008.10.014
更新日期:2009-01-01 00:00:00
abstract::Toxoplasma gondii can activate the nucleotide-binding domain and leucine-rich repeat-containing proteins NLRP1/3 inflammasomes, which mediate host resistance to the infection. Here we showed that deletion of mitogen-activated protein kinases MAPK1 and MAPK2 of type I parasite decreases acute virulence in mice, charact...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2016.07.004
更新日期:2016-11-01 00:00:00
abstract::Using a viral-induced immunopathology model, we showed that when CD4(+) T cells were allowed to undergo homeostatic expansion prior to ocular herpes simplex virus infection, mice developed more severe inflammatory lesions with the increased severity associated with enhanced effector function of ocular CD4(+) T cells, ...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2008.06.012
更新日期:2008-08-01 00:00:00
abstract::Two strains of mice selected according to extreme phenotypes of susceptibility and resistance to oral tolerance (TS and TR mice, respectively) were infected with 1 x 10(7) Leishmania amazonensis promastigotes and studied comparatively. TS mice developed a minor pathology while permitting parasite growth with the prese...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.09.018
更新日期:2006-04-01 00:00:00
abstract::Many intraerythrocytic hemoparasites survive the host immune system through rapid antigenic variation. Among babesial parasites antigenic variation has been demonstrated convincingly only for Babesia bovis and Babesia rodhaini. The molecular basis for antigenic variation in babesial parasites and its possible connecti...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(01)01404-6
更新日期:2001-05-01 00:00:00
abstract::This review considers whether the products of schistosomes in the mammalian host can be considered as virulence factors. These include: the cercarial secretions used in infection, those of the migrating schistosomulum, surface-exposed proteins of adult worms in the portal system and their gut vomitus in the context of...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2012.09.001
更新日期:2012-12-01 00:00:00