Abstract:
:The differential recognition of fungal cell wall polysaccharides that program innate and adaptive immunity to the human opportunistic fungal pathogen Aspergillus fumigatus has been a focus of considerable interest. In a mouse model of fungal conidia aspiration, decreased relative levels of cell wall core carbohydrates β-1,3-glucan to chitin in A. fumigatus isolates and mutant strains were correlated with increased airway eosinophil recruitment. In addition, an increase in fungal surface chitin exposure induced by the β-1,3-glucan synthesis-targeting drug caspofungin was associated with increased murine airway eosinophil recruitment after a single challenge of conidia. The response to increased A. fumigatus chitin was associated with increased transcription of IL-17A after a single aspiration, although this cytokine was not required for eosinophil recruitment. Rather, both RAG1 and γδ T cells were required, suggesting that this subset of innate-like lymphocytes may be an important regulator of potentially detrimental type 2 immune responses to fungal inhalation and infection.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Amarsaikhan N,O'Dea EM,Tsoggerel A,Templeton SPdoi
10.1016/j.micinf.2017.05.001subject
Has Abstractpub_date
2017-01-01 00:00:00pages
422-431issue
7-8eissn
1286-4579issn
1769-714Xpii
S1286-4579(17)30067-9journal_volume
19pub_type
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