Abstract：
:Humans and animals are colonized by members of the genus Staphylococcus, however only some of these species evolved to cause invasive disease. The genetic basis for conversion of commensal staphylococci into pathogens is not known. We hypothesized that Staphylococcus aureus genes for coagulation and agglutination in vertebrate blood (coa, vwb and clfA) may support pathogenic conversion. Expression of coa and vwb in Staphylococcus epidermidis or Staphylococcus simulans supported a coagulase-positive phenotype but not the ability to cause disease in a mouse model of bloodstream infection. However, the simultaneous expression of coa, vwb and clfA in coagulase-negative staphylococci enabled bacterial agglutination in plasma and enhanced survival of S. simulans in human whole blood. Agglutination of S. simulans in the bloodstream of infected mice upon expression of coa, vwb and clfA provided also a mean for dissemination and replication in distal organs. Thus, the acquisition of genes for bacterial agglutination with fibrin appear sufficient for the conversion of commensal staphylococci into invasive pathogens.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Yu W,Kim HK,Rauch S,Schneewind O,Missiakas Ddoi
10.1016/j.micinf.2016.12.002subject
Has Abstractpub_date
2017-02-01 00:00:00pages
101-109issue
2eissn
1286-4579issn
1769-714Xpii
S1286-4579(16)30194-0journal_volume
19pub_type
杂志文章abstract：:Pseudomonas aeruginosa, a significant cause of human morbidity and mortality, uses a type 3 secretion system (T3SS) to inject effector toxins into host cells. We previously reported that P. aeruginosa uses ADP-ribosyltransferase (ADPr) activity of the T3SS effector ExoS for intracellular replication. T3SS translocon (...
journal_title：Microbes and infection
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journal_title：Microbes and infection
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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journal_title：Microbes and infection
pub_type： 杂志文章
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更新日期：2007-02-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.07.009
更新日期：2007-10-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.05.005
更新日期：2006-08-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.10.006
更新日期：2007-01-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2014.03.010
更新日期：2014-07-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
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更新日期：2008-07-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2011.06.002
更新日期：2011-11-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Microbes and infection
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章
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更新日期：2004-09-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
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更新日期：2016-07-01 00:00:00
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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更新日期：2007-05-01 00:00:00
abstract：:To survive macrophage killing is critical in the pathogenesis of viridians streptococci-induced infective endocarditis (IE). Streptococcus mutans, an opportunistic IE pathogen, generally does not survive well phagocytic killing in murine macrophage RAW 264.7 cells. A putative two-component system (TCS), ScnR/ScnK from...
journal_title：Microbes and infection
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doi：10.1016/j.micinf.2007.12.006
更新日期：2008-03-01 00:00:00
