Abstract：
:Human infection with Toxoplasma gondii is generally asymptomatic in immunocompetent adults while it causes significant morbidity in congenitally infected children. Cell mediated immunity plays the main role in host resistance to T. gondii infection and a Th1 cytokine profile is necessary for protection and control of infection. The present work focused on comparing the helper T cell response to the GRA1 antigen of the parasite between children with congenital toxoplasmosis and healthy adults with acquired infection. We demonstrated that in young children with congenital infection the specific T cell response to parasite antigens is impaired and that such hypo-responsiveness is restored during childhood. Also, we provided clear evidence that in individuals with congenital toxoplasmosis the acquisition of functional helper T cell responses is disease-unrelated and indistinguishable in terms of strength, epitope specificity, and cytokine profile from the corresponding responses in immunocompetent adults with asymptomatic acquired T. gondii infection.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Guglietta S,Beghetto E,Spadoni A,Buffolano W,Del Porto P,Gargano Ndoi
10.1016/j.micinf.2006.10.017subject
Has Abstractpub_date
2007-02-01 00:00:00pages
127-33issue
2eissn
1286-4579issn
1769-714Xpii
S1286-4579(06)00380-7journal_volume
9pub_type
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