Abstract:
:Lactobacilli are normal inhabitants of our microbiota and are known to protect against pathogens. Neisseria gonorrhoeae is a human specific pathogenic bacterium that colonises the urogenital tract where it causes gonorrhoea. In this study we analysed early interactions between lactobacilli and gonococci and investigated how they compete for adherence to human epithelial cervical cells. We show that lactobacilli adhere at various levels and that the number of adherent bacteria does not correlate to the level of protection against gonococcal infection. Protection against gonococcal adhesion varied between Lactobacillus species. Lactobacillus crispatus, Lactobacillus gasseri and Lactobacillus reuteri were capable of reducing gonococcal adherence while Lactobacillus rhamnosus was not. Lactobacillus strains of vaginal origin had the best capacity to remain attached to the host cell during gonococcal adherence. Further, we show that gonococci and lactobacilli interact with each other with resultant lactobacilli incorporation into the gonococcal microcolony. Hence, gonococci bind to colonised lactobacilli and this complex frequently detaches from the epithelial cell surface, resulting in reduced bacterial colonisation. Also, purified gonococcal pili are capable of removing adherent lactobacilli from the cell surface. Taken together, we reveal novel data regarding gonococcal and lactobacilli competition for adherence that will benefit future gonococcal prevention and treatments.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Vielfort K,Sjölinder H,Roos S,Jonsson H,Aro Hdoi
10.1016/j.micinf.2008.07.032subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1325-34issue
12-13eissn
1286-4579issn
1769-714Xpii
S1286-4579(08)00226-8journal_volume
10pub_type
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journal_title:Microbes and infection
pub_type: 杂志文章
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journal_title:Microbes and infection
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2004.09.017
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
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journal_title:Microbes and infection
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journal_title:Microbes and infection
pub_type: 杂志文章
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.05.009
更新日期:2006-08-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2007.09.013
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journal_title:Microbes and infection
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2018.10.006
更新日期:2019-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,随机对照试验
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更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Microbes and infection
pub_type: 杂志文章
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journal_title:Microbes and infection
pub_type: 杂志文章
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journal_title:Microbes and infection
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doi:10.1016/j.micinf.2007.10.002
更新日期:2008-01-01 00:00:00
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journal_title:Microbes and infection
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journal_title:Microbes and infection
pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2010.12.003
更新日期:2011-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2011.09.002
更新日期:2012-02-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/s1286-4579(02)01646-5
更新日期:2002-10-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.11.011
更新日期:2006-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2004.12.012
更新日期:2005-03-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2005.12.001
更新日期:2006-04-01 00:00:00