Abstract：
:The bacterium Haemophilus ducreyi causes the sexually transmitted disease chancroid, which is characterized by the appearance of mucocutaneous, persistent ulcers on the external genitals. To identify carbohydrate receptors that mediate the attachment of this pathogen to host cells, we investigated the binding of 35S-methionine-labeled H. ducreyi strains to a panel of defined glycosphingolipids that were separated on thin layer chromatography plates. H. ducreyi bound to lactosylceramide, gangliotriaosylceramide, gangliotetraosylceramide, neolactotetraosylceramide, the GM3 ganglioside, and sulfatide. To elucidate the role of the surface-located 58.5-kDa GroEL heat shock protein (HSP) of H. ducreyi in attachment, we investigated the binding of purified HSP to the same panel of glycosphingolipids. Our results suggest that the 58.5-kDa GroEL HSP of H. ducreyi is responsible for the attachment of this bacterium to the majority of the tested glycosphingolipids, and thus represents a potential bacterial adhesin.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Pantzar M,Teneberg S,Lagergård Tdoi
10.1016/j.micinf.2006.05.009subject
Has Abstractpub_date
2006-08-01 00:00:00pages
2452-8issue
9-10eissn
1286-4579issn
1769-714Xpii
S1286-4579(06)00229-2journal_volume
8pub_type
杂志文章abstract：:Translocation of normally non-pathogenic bacteria across the gut may drive inflammatory responses associated with sepsis and inflammatory bowel disease. Recent evidence suggests translocation may not be purely passive, but occurs via novel transcellular pathways activated in enterocytes by inflammatory and metabolic s...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.01.001
更新日期：2008-04-01 00:00:00
abstract：:Nonsense-mediated mRNA decay (NMD) is an essential and conserved cellular mRNA quality control mechanism. RNA signals to express viral genes from overlapping open reading frames potentially initiate NMD, nevertheless it is not clear whether viral RNAs are sensitive to NMD or if viruses have evolved mechanisms to evade...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.03.006
更新日期：2013-06-01 00:00:00
abstract：:We tested the hypothesis that host resistance to Campylobacter jejuni is Nramp1 dependent. Following intraperitoneal (IP) inoculation of Nramp1+/+ and isogenic Nramp1-deficient (Nramp1-/-) mice C. jejuni primarily associated with mac1-positive cells in liver tissue. A significant reduction of C. jejuni was observed in...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.05.001
更新日期：2008-07-01 00:00:00
abstract：:The Gram-negative bacterium Burkholderia cepacia has recently emerged as an important opportunistic pathogen in humans. This review focuses on the cellular aspects of B. cepacia infection and the dynamics of the B. cepacia-host cell interaction, including recent advances in our understanding of the ability of B. cepac...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(01)01389-2
更新日期：2001-04-01 00:00:00
abstract：:The establishment of infection by Brucella ovis and Brucella canis in J774.A1 macrophages was found to be dependent upon cholesterol and ganglioside GM(1), two components of lipid rafts. This process also required a class A scavenger receptor of macrophages, and was not inhibited by smooth and rough lipopolysaccharide...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2009.12.008
更新日期：2010-03-01 00:00:00
abstract：:Infection with Helicobacter pylori cagA-positive strains plays an essential role in the development of gastric carcinoma. This review summarizes the pathophysiological functions of the cagA gene product, CagA, particularly focusing on the molecular mechanisms underlying CagA translocation into the host cells as well a...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2011.03.011
更新日期：2011-09-01 00:00:00
abstract：:AIDS patients frequently exhibit neurological disorders due to the neurotoxic events that result from HIV-1 and/or opportunistic infections in the brain. This review examines recent clinical findings related to HIV-1-associated dementia, and outlines current areas of basic research that may clarify how HIV-1-associate...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01542-3
更新日期：2002-03-01 00:00:00
abstract：:Influenza A virus (IAV) is a pulmonary pathogen, responsible for significant yearly morbidity and mortality. Due to the absence of highly effective antiviral therapies and vaccine, as well as the constant threat of an emerging pandemic strain, there is considerable need to better understand the host-pathogen interacti...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2018.03.005
更新日期：2018-01-01 00:00:00
abstract：:Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2005.12.001
更新日期：2006-04-01 00:00:00
abstract：:The internalization of Aspergillus fumigatus into lung epithelial cells is critical for the infection process in the host. Gliotoxin is the most potent toxin produced by A. fumigatus. However, its role in A. fumigatus internalization into the lung epithelial cells is still largely unknown. In the present study, the de...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2014.03.001
更新日期：2014-06-01 00:00:00
abstract：:To survive macrophage killing is critical in the pathogenesis of viridians streptococci-induced infective endocarditis (IE). Streptococcus mutans, an opportunistic IE pathogen, generally does not survive well phagocytic killing in murine macrophage RAW 264.7 cells. A putative two-component system (TCS), ScnR/ScnK from...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.12.006
更新日期：2008-03-01 00:00:00
abstract：:Overlapping peptides of different lengths from a certain immunodominant region can be presented by the same HLA class I molecule and elicit different T cell responses. However, how peptide-length specificity of antigen-specific CD8(+) T lymphocytes influence cross-reactivity profiles of these cells remains elusive. Th...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.12.005
更新日期：2014-04-01 00:00:00
abstract：:The Mycobacterium abscessus complex can cause fatal pulmonary disease, especially in cystic fibrosis patients. Diagnosing M. abscessus complex pulmonary disease is challenging. Immunologic assays specific for M. abscessus are not available. In this study seven clinical M. abscessus complex strains and the M. abscessus...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2018.10.006
更新日期：2019-01-01 00:00:00
abstract：:Protein kinase RNA activated (PKR) is a crucial mediator of anti-viral responses but is reported to be activated by multiple non-viral stimuli. However, mechanisms underlying PKR activation, particularly in response to bacterial infection, remain poorly understood. We have investigated mechanisms of PKR activation in ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2016.03.010
更新日期：2016-07-01 00:00:00
abstract：:The type III secretion system of Salmonella enterica serovar Typhimurium can be used to target heterologous antigens directly into the cytosol of antigen-presenting cells. Our laboratory has previously reported that the single oral immunization of mice with a recombinant Salmonella strain expressing the translocated Y...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.02.007
更新日期：2005-05-01 00:00:00
abstract：:We previously showed that human corneal epithelial cells (HCECs) express Toll-like receptors (TLRs), which recognize gram-positive bacteria and respond to Staphylococcus aureus infection by the expression and secretion of proinflammatory cytokines and beta-defensin-2 (hBD2). In this study, we further elucidated the un...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.07.006
更新日期：2006-02-01 00:00:00
abstract：:Phagocytosis is important in immune defense and development in vertebrates and invertebrates. It leads to swift ingestion of microorganisms and dying cells by phagocytes. How particles are recognized is not well understood. Studies in insects, and Drosophila in particular, argue that these are powerful model systems t...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)00304-x
更新日期：2000-03-01 00:00:00
abstract：:Campylobacter jejuni and Campylobacter coli together represent the leading bacterial cause of human enteritis. However, the pathogenesis of this disease is poorly understood. Infection results in the formation of crypt abscesses resulting from the migration of neutrophils across the intestinal epithelium and into the ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2010.09.007
更新日期：2011-01-01 00:00:00
abstract：:CCR5-tropic (R5) immunodeficiency virus type 1 (HIV-1) strains are highly transmissible during the early stage of infection in humans, whereas CXCR4-tropic (X4) strains are less transmissible. This study aimed to explore the basis for early phase R5 and X4 HIV-1 infection in vivo by using humanized mice dually challen...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.02.002
更新日期：2015-05-01 00:00:00
abstract：:Despite the development of new treatments, the mortality due to invasive pulmonary aspergillosis remains above 50%, reaching 95% in certain situations. The battle against Aspergillus fumigatus involves several components of the pulmonary innate immune system: cells, mediators, and natural antifungal molecules involved...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2009.07.002
更新日期：2009-10-01 00:00:00
abstract：:Several observations suggest that inhibition of the host complement alternative pathway by Ixodes tick saliva is crucial to achieve blood feeding. We recently described two paralogous anti-complement proteins called Ixodes ricinus anti-complement (IRAC) proteins I and II co-expressed in I. ricinus salivary glands. Phy...
journal_title：Microbes and infection
pub_type： 信件
doi：10.1016/j.micinf.2006.10.020
更新日期：2007-02-01 00:00:00
abstract：:About the relationship between retroviral genome packaging and translation, three possible modes (random-, trans-, and cis-) of packaging process could be assumed. In this report, we developed an assay system based on the RT-qPCR to measure the packaging efficiency of primate lentiviruses. With this system, we analyze...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2018.09.002
更新日期：2019-03-01 00:00:00
abstract：:Salmonella, a Gram-negative facultative intracellular pathogen is capable of infecting vast array of hosts. The striking ability of Salmonella to overcome every hurdle encountered in the host proves that they are true survivors. In the host, Salmonella infects various cell types and needs to survive and replicate by c...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2010.05.010
更新日期：2010-10-01 00:00:00
abstract：:GB virus B (GBV-B) infection of New World monkeys is considered to be a useful surrogate model for hepatitis C virus (HCV) infection. GBV-B replicates in the liver and induces acute resolving hepatitis but little is known whether the other organs could be permissive for the virus. We investigated the viral tropism of ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.01.010
更新日期：2007-04-01 00:00:00
abstract：:Infection with Chlamydia pneumoniae, a human respiratory pathogen, has been associated with various chronic diseases such as asthma and atherosclerosis, possibly because the pathogen can exist in a persistent form. C. pneumoniae persistently infect DCs in a TNF-alpha dependent manner. The present study investigated wh...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2009.07.006
更新日期：2009-11-01 00:00:00
abstract：:Sheep develop clinical diseases after 3-5 years after infection with Mycobacterium avium subsp. paratuberculosis (MAP). Clinical symptoms of paratuberculosis include persistent diarrhea and weight loss due to a chronic inflammation of the small intestine. Tissue alterations in the areas of the ileo-cecal junction are ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2009.04.006
更新日期：2009-05-01 00:00:00
abstract：:Brucella abortus is an intracellular bacterium that establishes lifelong infections in livestock and humans although the mechanisms of its chronicity are poorly understood. Activated B cells have long lifespan and B. abortus infection activates B cells. Our results indicate that the direct infection of B cells with B....
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2016.04.001
更新日期：2016-09-01 00:00:00
abstract：:Francisella tularensis causes the zoonosis tularemia in humans, and inhaled F. tularensis ssp. novicida induces lethal murine tularemia. Transcription of virulence factors in F. novicida is regulated by macrophage growth locus A (mglA), a global regulator required for bacterial replication in macrophages in vitro. We ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.04.008
更新日期：2008-06-01 00:00:00
abstract：:Clostridium difficile is now established as a major nosocomial pathogen. C. difficile infection is seen almost exclusively as a complication of antibiotic therapy, and is particularly associated with clindamycin and third-generation cephalosporins. Depletion of the indigenous gut microflora by antibiotic therapy has l...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(99)80054-9
更新日期：1999-04-01 00:00:00
abstract：:BALB/c mice immunized with cruzipain, a major Trypanosoma cruzi antigen, produce specific and autoreactive immune responses against heart myosin, associated with cardiac functional and structural abnormalities. Preferential activation of the Th2 phenotype and an increase in cell populations expressing CD19+, Mac-1+ an...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.07.010
更新日期：2004-11-01 00:00:00
