Abstract：
:Influenza A virus (IAV) is a pulmonary pathogen, responsible for significant yearly morbidity and mortality. Due to the absence of highly effective antiviral therapies and vaccine, as well as the constant threat of an emerging pandemic strain, there is considerable need to better understand the host-pathogen interactions and the factors that dictate a protective versus detrimental immune response to IAV. Even though evidence of IAV-induced cell death in human pulmonary epithelial and immune cells has been observed for almost a century, very little is known about the consequences of cell death on viral pathogenesis. Recent study indicates that both the type of cell death program and its kinetics have major implications on host defense and survival. In this review, we discuss advances in our understanding of cell death programs during influenza virus infection, in hopes of fostering new areas of investigation for targeted clinical intervention.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Downey J,Pernet E,Coulombe F,Divangahi Mdoi
10.1016/j.micinf.2018.03.005subject
Has Abstractpub_date
2018-01-01 00:00:00pages
560-569issue
9-10eissn
1286-4579issn
1769-714Xpii
S1286-4579(18)30093-5journal_volume
20pub_type
杂志文章,评审abstract：:In developed countries, enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a leading cause of bloody diarrhea and renal failures in human. Understanding strategies employed by EHEC to colonize the intestine is of major importance since to date no cure exists to eradicate the pathogen. In this study, the adaptive res...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2014.09.008
更新日期：2015-01-01 00:00:00
abstract：:Pathogenic Leptospira species are the causative agents of leptospirosis, a global zoonotic infectious disease. Toxin-antitoxin (TA) modules have been confirmed as stress-response elements that induce prokaryotic and eukaryotic cell-growth arrest or death, but their role in the virulence of Leptospira has not been repo...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2014.10.010
更新日期：2015-01-01 00:00:00
abstract：:Cell-mediated immunity, leading to Mycobacterium tuberculosis (Mtb)-constraining granuloma formation, is the major component of host defense against tuberculosis and is regulated by the balance of cytokines secreted mostly by mononuclear phagocytes and lymphocytes. To better understand the role of monocytes in the reg...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2003.10.007
更新日期：2004-01-01 00:00:00
abstract：:Human immunodeficiency virus type 1 (HIV-1) mostly owes its success to its ability to evade host immune responses. Understanding viral immune escape mechanisms is a prerequisite to improve future HIV-1 vaccine design. This review focuses on the strategies that HIV-1 has evolved to evade recognition by natural killer (...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2012.05.001
更新日期：2012-09-01 00:00:00
abstract：:Despite high vaccination coverage, pertussis remains an important respiratory infectious disease and the least-controlled vaccine-preventable infectious disease in children. Natural infection with Bordetella pertussis is known to induce strong and long-lasting immunity that wanes later than vaccine-mediated immunity. ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.10.002
更新日期：2014-01-01 00:00:00
abstract：:Following infection with Toxoplasma gondii, certain strains of mice, such as BALB/c, are genetically resistant to development of toxoplasmic encephalitis (TE) and establish a latent chronic infection as do humans. Thus, these animals appear to be a suitable model to analyze the mechanism of resistance to TE. Since the...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(00)00318-x
更新日期：2000-04-01 00:00:00
abstract：:We produced a B95a lymphoid cell line persistently infected with canine distemper virus (CDV), in which virus-specific antigens were present in nearly 100% of cells without causing cytopathic effect. The virus recovered from this cell line was able to infect fresh B95a cells persistently, indicating that a persistent ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(99)80516-4
更新日期：1999-10-01 00:00:00
abstract：:The differentiation and survival of developing alpha beta thymocytes depends on effective T-cell receptor (TCR) signaling upon recognition of self peptide/major histocompatibility complex (MHC) molecule ligands. Although this concept is uniformly accepted with regard to immature thymocytes, there are conflicting repor...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01571-x
更新日期：2002-04-01 00:00:00
abstract：:E protein is a membrane component of severe acute respiratory syndrome coronavirus (SARS-CoV). Disruption of E protein may reduce viral infectivity. Thus, the SARS-CoV E protein is considered a potential target for the development of antiviral drugs. However, the cellular immune responses to E protein remain unclear i...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.05.008
更新日期：2006-08-01 00:00:00
abstract：:Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to improve MYXV as an onco...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2010.08.012
更新日期：2010-12-01 00:00:00
abstract：:Foot-and-mouth disease virus (FMDV) is a member of the Aphthovirus genus in the Picornaviridae family. Seven distinct serotypes, each including a wide range of variants, have been defined. FMD, affects wild and domesticated ruminants and pigs, is difficult to control and is the major constraint to international trade ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01634-9
更新日期：2002-08-01 00:00:00
abstract：:Strongyloides venezuelensis migrates through the lungs and induces airway hyperresponsiveness (AHR). The present study evaluated the role of C-fibers in mediating airway inflammation and AHR after infection of rats with S. venezuelensis. Neonatal treatment with capsaicin effectively depleted sensory nerves. This was a...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.11.015
更新日期：2009-02-01 00:00:00
abstract：:Host defense requires the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and the induction of pyroptotic cell death, which depends on the activation of inflammatory Caspases within inflammasomes by innate immune cells. Several cytosolic pattern recognition receptors (PRRs) have ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2013.04.001
更新日期：2013-07-01 00:00:00
abstract：:Microsporidia are intracellular pathogens that cause severe disease in immunocompromised humans and animals. We recently demonstrated that XID mice are more susceptible to Encephalitozoon cuniculi infection by intraperitoneal route, evidencing the role of B-1 cells in resistance against infection. The present study in...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2017.11.004
更新日期：2018-03-01 00:00:00
abstract：:Osteoarticular brucellosis is the most frequent complication of active disease. A large amount of cells in bone are osteocytes. Since bone remodeling process is regulated by hormones we sought to study the effect of cortisol and DHEA in Brucella abortus-infected osteocytes. Cortisol treatment inhibited the expression ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2019.01.004
更新日期：2019-01-01 00:00:00
abstract：:Nonsense-mediated mRNA decay (NMD) is an essential and conserved cellular mRNA quality control mechanism. RNA signals to express viral genes from overlapping open reading frames potentially initiate NMD, nevertheless it is not clear whether viral RNAs are sensitive to NMD or if viruses have evolved mechanisms to evade...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.03.006
更新日期：2013-06-01 00:00:00
abstract：:Lactic acid bacteria (LAB) show anti-inflammatory effects, and their genomic DNA was identified as one of the anti-inflammatory components. Despite the differences in anti-inflammatory effects between live LAB dependent not only on genus but also species, this effect has not been compared at the genomic DNA level. We ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2012.11.003
更新日期：2013-02-01 00:00:00
abstract：:Our previous study demonstrated the anti-apoptosis function of the human immunodeficiency virus type 1 (HIV-1) vpu gene product in normal CD4+ T lymphocytes. In this study, using sequences obtained from the HIV sequence database, we compared vpu sequences from 184 preparations of various subtypes of HIV-1 from diverse...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.09.017
更新日期：2005-02-01 00:00:00
abstract：:Oropouche virus is the aetiological agent of Oropouche fever, a zoonotic disease mainly transmitted by midges of the species Culicoides paraensis. Although the virus was discovered in 1955, more attention has been given recently to both the virus and the disease due to outbreaks of Oropouche fever in different areas o...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2017.11.013
更新日期：2018-03-01 00:00:00
abstract：:BCG rectal administration to newborn and adult mice induced protective immune responses against tuberculosis. BCG reaches the sub-epithelial site and the draining mesenteric lymph nodes (MLNs), and dendritic cells (DC) could be recruited to these sites. Using polarized Caco-2 epithelial cells, we showed that BCG trans...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.03.022
更新日期：2006-08-01 00:00:00
abstract：:Very recently, a new avian flu outbreak in humans, which is caused by a novel H7N9 influenza A virus (AIV), was reported in China. As of April 13, 2013, 49 confirmed cases (mainly middle-aged to elderly males), including 11 deaths, were reported in China. Here we analyzed the genomic signatures and protein sequences o...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.04.004
更新日期：2013-06-01 00:00:00
abstract：:Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2005.12.001
更新日期：2006-04-01 00:00:00
abstract：:In this report, we examined the genetic diversity of HIV-1 strains circulating in the city of Beira, the second largest metropolitan area in Mozambique. A total of 131 blood samples, collected between August and October 2003 from antiretroviral-naïve individuals, were characterized with a combined approach consisting ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.05.005
更新日期：2006-08-01 00:00:00
abstract：:The Gram-negative bacterium Burkholderia cepacia has recently emerged as an important opportunistic pathogen in humans. This review focuses on the cellular aspects of B. cepacia infection and the dynamics of the B. cepacia-host cell interaction, including recent advances in our understanding of the ability of B. cepac...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(01)01389-2
更新日期：2001-04-01 00:00:00
abstract：:Recent studies by DNA-DNA hybridisation assays conducted on a large collection of Escherichia coli strains isolated from chickens, ducks and turkeys suffering from colibacillosis, showed that 76% of the strains were negative for the presence of the pap gene cluster. The objective of this paper was to study the virulen...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.03.006
更新日期：2004-06-01 00:00:00
abstract：:To investigate the association of viral infections with chronic fatigue syndrome (CFS), we assayed 2', 5'-oligoadenylate synthetase (2-5AS) activities in peripheral blood mononuclear cells from CFS patients in Japan. These patients were diagnosed in two hospitals, H1 and H2, located in different areas of the country. ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2003.07.002
更新日期：2003-10-01 00:00:00
abstract：:The influenza viruses contain highly variable genomes and are able to infect a wide range of host species. Large-scale sequencing projects have collected abundant influenza sequence data for assessing influenza genome diversity and evolution. This work reviews current influenza sequence databases characteristics and s...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2011.01.013
更新日期：2011-05-01 00:00:00
abstract：:We analyzed the distribution and expression of cadherin and beta-catenin during Trypanosoma cruzi-cardiomyocyte interaction. Confocal microscopy revealed cadherin associated with beta-catenin at the cell-cell contacts. After 24h of infection, the spatial distribution and expression of both adherens junction (AJ) prote...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.07.044
更新日期：2008-10-01 00:00:00
abstract：:Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticat...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2009.10.002
更新日期：2010-02-01 00:00:00
abstract：:Vibrio vulnificus is capable of causing severe and often fatal infections in susceptible individuals. It causes two distinct disease syndromes, a primary septicemia and necrotizing wound infections. This review discusses the interaction of environmental conditions, host factors, and bacterial virulence determinants th...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)00270-7
更新日期：2000-02-01 00:00:00
