Abstract：
:Osteoarticular brucellosis is the most frequent complication of active disease. A large amount of cells in bone are osteocytes. Since bone remodeling process is regulated by hormones we sought to study the effect of cortisol and DHEA in Brucella abortus-infected osteocytes. Cortisol treatment inhibited the expression of IL-6, TNF-α, MMP-2 and RANKL in B. abortus-infected osteocytes. DHEA could reverse the inhibitory effect of cortisol on MMP-2 production. B. abortus infection inhibited connexin 43 (Cx43) expression in osteocytes. This expression was increased when cortisol was incorporated during the infection and DHEA treatment partially reversed the effect of cortisol. Osteocytes-infected with B. abortus induced osteoclast's differentiation. Yet, the presence of cortisol, but not DHEA, during osteocyte infection inhibited osteoclastogenesis. Glucocorticoid receptor (GR) is implicated in the signaling of cortisol. Infection with B. abortus was able to increase GRα/β ratio. Levels of intracellular cortisol are not only dependent on GR expression but also a result of the activity of the isoenzymes 11β-hydroxysteroid dehydrogenase (11β-HSD)-1 (cortisone to cortisol conversion), 11β-HSD2 (cortisol to cortisone conversion). B. abortus infection increased 11β-HSD 1/2 ratio and cortisone mimicked the effect of cortisol. Our results indicated that cortisol and DHEA could modulate osteocyte responses during B. abortus infection.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Pesce Viglietti AI,Giambartolomei GH,Delpino MVdoi
10.1016/j.micinf.2019.01.004subject
Has Abstractpub_date
2019-01-01 00:00:00pages
287-295issue
7eissn
1286-4579issn
1769-714Xpii
S1286-4579(19)30006-1journal_volume
21pub_type
杂志文章abstract：:We investigated the relationship between antibody response to the major Paracoccidioides brasiliensis antigen, a 43-kDa glycoprotein, and the two paracoccidioidomycosis (PCM) clinical presentations, the juvenile and the adult forms. Total immunoglobulin G (IgG), IgG isotypes, and IgA anti-gp43 antibodies were determin...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(99)80022-7
更新日期：1999-04-01 00:00:00
abstract：:In vitro cell culture models used to study how Salmonella initiates disease at the intestinal epithelium would benefit from the recognition that organs and tissues function in a three-dimensional (3-D) environment and that this spatial context is necessary for development of cultures that more realistically resemble i...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.02.020
更新日期：2006-06-01 00:00:00
abstract：:In order to invade mammalian cells, Trypanosoma cruzi infective forms cause distinct rearrangements of membrane and host cell cytoskeletal components. Rho GTPases have been shown to regulate three separate signal transduction pathways, linking plasma membrane receptors to the assembly of distinct actin filament struct...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.01.009
更新日期：2004-04-01 00:00:00
abstract：:Mucosal epithelia constitute the first barriers to be overcome by pathogens during infection. The induction of protective IgA in this location is important for the prevention of infection and can be achieved through different mucosal immunization strategies. Lactic acid bacteria have been tested in the last few years ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.10.020
更新日期：2006-04-01 00:00:00
abstract：:Although the pathogenesis of periodontal disease (PD) is not well known, cytokines, chemotactic factors and inflammatory cells are certainly involved in the disease outcome. Here, we characterized the evolution of the PD induced by Actinobacillus actinomycetemcomitans in mice, showing that oral inoculation of these ba...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.01.012
更新日期：2005-04-01 00:00:00
abstract：:Experimental cutaneous leishmaniasis is a useful model in studying the mechanism regulating immune responses between T helper type 1 (Th1) and Th2. Mice susceptible to Leishmania major infection such as BALB/c (H-2(d)) are associated with the induction of the disease-promoting Th2 response, while the resistant mice su...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(00)01298-3
更新日期：2000-10-01 00:00:00
abstract：:The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue i...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2012.04.011
更新日期：2012-08-01 00:00:00
abstract：:Pneumococcal serine-rich repeat protein (PsrP) is a glycoprotein that mediates Streptococcus pneumoniae attachment to lung cells and promotes biofilm formation. Herein, we investigated the transcriptional organization of psrP-secY2A2, the 37-kbp pathogenicity island encoding PsrP and its accessory genes. PCR amplifica...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2017.04.001
更新日期：2017-06-01 00:00:00
abstract：:Erythritol is a four-carbon sugar preferentially utilized by Brucella spp. The presence of erythritol in the placentas of goats, cows, and pigs has been used to explain the localization of Brucella to these sites and the subsequent accumulation of large amounts of bacteria, eventually leading to abortion. Here we show...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.02.002
更新日期：2013-06-01 00:00:00
abstract：:Fungal allergy including allergic rhinitis, conjunctivitis, bronchial asthma, and allergic bronchopulmonary mycoses results from exposure to spores. In this review we have dealt with the common allergenic fungi and allergens, immunopathogenesis, diagnostic assays, and the possible control of allergy in the future base...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)01264-8
更新日期：2000-07-01 00:00:00
abstract：:This review elaborates on recent insights gained on the dynamic aspects of interactions between pathogen and the host intracellular machinery in tuberculosis infection. In addition we will also discuss the utility of adopting a systems biology approach, both for a better understanding of TB biology, and for the develo...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2010.10.009
更新日期：2011-02-01 00:00:00
abstract：:Anaerobic bacteria can cause a variety of endogenous infections in children. Because of their fastidious nature, they are difficult to isolate from infectious sites, and are often overlooked. Anaerobic infections can occur in all body sites, including the central nervous system, oral cavity, head and neck, chest, abdo...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01656-8
更新日期：2002-10-01 00:00:00
abstract：:Several glycoforms of CD43 are known to regulate cellular interactions in the immune system. One such glycoform, the CD43 that bears core 2 O-glycans, is also known to be expressed on T lymphocytes and natural killer cells, but only after their activation. Previous studies have also shown that when Caco-2 cells, which...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(01)01431-9
更新日期：2001-07-01 00:00:00
abstract：:Measles and pertussis are ubiquitous vaccine-preventable diseases, which remain an important public health problem in developing countries. Hence, developing a deep understanding of their transmission dynamics remains imperative. To achieve this, we compared the impact of vaccination at both individual and population ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.12.018
更新日期：2005-04-01 00:00:00
abstract：:The inner ear has been regarded as an immunoprivileged site because of isolation by the blood-labyrinthine barrier. Several reports have indicated the existence of immune cells in the inner ear, but there are no reports showing immunocompetence of the cochlear tissue. In this report, we examined the potential involvem...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.04.008
更新日期：2013-07-01 00:00:00
abstract：:Monoxenous trypanosomatids usually have an invertebrate as the only host in their life cycles, however, they have been found repeatedly in plants and/or mammals. To succeed in colonizing a vertebrate host, the parasite must quickly adapt to drastic changes in the environment (e.g. temperature), which reflect the condi...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2010.07.010
更新日期：2010-11-01 00:00:00
abstract：:Salmonella, a Gram-negative facultative intracellular pathogen is capable of infecting vast array of hosts. The striking ability of Salmonella to overcome every hurdle encountered in the host proves that they are true survivors. In the host, Salmonella infects various cell types and needs to survive and replicate by c...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2010.05.010
更新日期：2010-10-01 00:00:00
abstract：:CCR5-tropic (R5) immunodeficiency virus type 1 (HIV-1) strains are highly transmissible during the early stage of infection in humans, whereas CXCR4-tropic (X4) strains are less transmissible. This study aimed to explore the basis for early phase R5 and X4 HIV-1 infection in vivo by using humanized mice dually challen...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.02.002
更新日期：2015-05-01 00:00:00
abstract：:Coxiella burnetii is an intracellular bacterium that causes acute and chronic Q fever. This unique pathogen has been historically challenging to study due to obstacles in genetically manipulating the organism and the inability of small animal models to fully mimic human Q fever. Here, we review the current state of C....
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2019.09.001
更新日期：2020-04-01 00:00:00
abstract：:There is increasing evidence that myeloid cells express several receptor families, which include both inhibitory and stimulatory isoforms. The expression of receptor isoforms with similar specificities but opposite functions on the same cell is intriguing. What might be the interplay between these receptors? Some clue...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)00294-x
更新日期：2000-03-01 00:00:00
abstract：:Histoplasma capsulatum is an important fungal pathogen in immunocompromised hosts, including AIDS patients. Experimental evidence suggests interferon-gamma (IFN) plays a role in host defense against H. capsulatum. In these studies we sought to demonstrate the importance of IFN in innate resistance to systemic histopla...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(00)01253-3
更新日期：2000-07-01 00:00:00
abstract：:Ebolavirus can cause a highly fatal and panic-generating human disease which may jump from bats to other mammals and human. High viral loads in body fluids allow efficient transmission by contact. Lack of effective antivirals, vaccines and public health infrastructures in parts of Africa make it difficult to health wo...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2014.11.007
更新日期：2015-02-01 00:00:00
abstract：:The objective of this study was to determine if inflammatory tolerance and enhancement of innate immune function could be induced by the Gram-positive cell wall component peptidoglycan (PGN). Male mice (C57BL6/J or C3H/HeJ, 8-12 weeks of age) were given intraperitoneal injections of 1mg PGN on 2 consecutive days. The ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.07.021
更新日期：2008-10-01 00:00:00
abstract：:Lipoarabinomannans (LAMs) from mycobacteria were investigated concerning their effect on human neutrophils. Two types of LAM, the mannose-capped ManLAM from the virulent Mycobacterium tuberculosis H37Rv and the mannose-lacking AraLAM from a rapidly growing mycobacterial strain were used. Neither AraLAM nor ManLAM indu...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(01)01470-8
更新日期：2001-11-01 00:00:00
abstract：:BCG rectal administration to newborn and adult mice induced protective immune responses against tuberculosis. BCG reaches the sub-epithelial site and the draining mesenteric lymph nodes (MLNs), and dendritic cells (DC) could be recruited to these sites. Using polarized Caco-2 epithelial cells, we showed that BCG trans...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.03.022
更新日期：2006-08-01 00:00:00
abstract：:Campylobacter jejuni is one of the most common causes of bacterial gastroenteritis and chronic sequelae, such as reactive arthritis and Guillain-Barré syndrome (GBS), are known to follow uncomplicated infections. While little is known about reactive arthritis following Campylobacter infection, our knowledge on the pat...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01553-8
更新日期：2002-04-01 00:00:00
abstract：:Borna disease virus (BDV) is a noncytolytic, neurotropic RNA virus that causes neurobehavioral disorders in a wide variety of warm-blooded animals. Recent evidence has revealed that BDV uses a unique strategy in its transcription and replication and directly affects cellular functions of infected central nervous syste...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01564-2
更新日期：2002-04-01 00:00:00
abstract：:Translocation of normally non-pathogenic bacteria across the gut may drive inflammatory responses associated with sepsis and inflammatory bowel disease. Recent evidence suggests translocation may not be purely passive, but occurs via novel transcellular pathways activated in enterocytes by inflammatory and metabolic s...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.01.001
更新日期：2008-04-01 00:00:00
abstract：:Phocid herpesvirus virus type 2 (PhHV-2), a putative gammaherpesvirus of seals, has been isolated from harbor seals (Phoca vitulina) and grey seals (Halichoerus grypus). In the present study, different PhHV-2 isolates were shown to have a broad in vitro tropism for various cell types from several mammalian species. In...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.10.006
更新日期：2007-01-01 00:00:00
abstract：:Genome sequences of 36 Rickettsia and Orientia were analyzed using Formal Order Analysis (FOA). This approach takes into account arrangement of nucleotides in each sequence. A numerical characteristic, the average distance (remoteness) - "g" was used to compare of genomes. Our results corroborated previous separation ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.09.012
更新日期：2015-11-01 00:00:00
