In vitro and in vivo replication of seal gammaherpesviruses in cells of multiple species.

Abstract:

:Phocid herpesvirus virus type 2 (PhHV-2), a putative gammaherpesvirus of seals, has been isolated from harbor seals (Phoca vitulina) and grey seals (Halichoerus grypus). In the present study, different PhHV-2 isolates were shown to have a broad in vitro tropism for various cell types from several mammalian species. Inbred mice and two species of non-human primates proved to be susceptible to experimental infection with PhHV-2. The development of myoepitheliomas and spleen hyperplasia upon cyclosporin A treatment in some of the PhHV-2-infected animals warrants further investigation of the oncogenic and zoonotic potential of this virus.

journal_name

Microbes Infect

journal_title

Microbes and infection

authors

Martina BE,Verjans GM,Kuiken T,van Amerongen G,Osterhaus AD

doi

10.1016/j.micinf.2006.10.006

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

40-6

issue

1

eissn

1286-4579

issn

1769-714X

pii

S1286-4579(06)00369-8

journal_volume

9

pub_type

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