Abstract:
:Phocid herpesvirus virus type 2 (PhHV-2), a putative gammaherpesvirus of seals, has been isolated from harbor seals (Phoca vitulina) and grey seals (Halichoerus grypus). In the present study, different PhHV-2 isolates were shown to have a broad in vitro tropism for various cell types from several mammalian species. Inbred mice and two species of non-human primates proved to be susceptible to experimental infection with PhHV-2. The development of myoepitheliomas and spleen hyperplasia upon cyclosporin A treatment in some of the PhHV-2-infected animals warrants further investigation of the oncogenic and zoonotic potential of this virus.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Martina BE,Verjans GM,Kuiken T,van Amerongen G,Osterhaus ADdoi
10.1016/j.micinf.2006.10.006subject
Has Abstractpub_date
2007-01-01 00:00:00pages
40-6issue
1eissn
1286-4579issn
1769-714Xpii
S1286-4579(06)00369-8journal_volume
9pub_type
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