Abstract:
:Strongyloides venezuelensis migrates through the lungs and induces airway hyperresponsiveness (AHR). The present study evaluated the role of C-fibers in mediating airway inflammation and AHR after infection of rats with S. venezuelensis. Neonatal treatment with capsaicin effectively depleted sensory nerves. This was accompanied by inhibition of the AHR induced by S. venezuelensis infection. In contrast, capsaicin treatment greatly enhanced pulmonary inflammation, eosinophil influx and the local production of TNF-alpha. In conclusion, this is the first demonstration that, akin to viral and allergic AHR, permanent loss of sensory nerve C-fibers also reduces AHR induced by infection with a helminth.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Ferreira CM,Pereira AT,Amaral FA,de Souza RS,Coelho FM,Souza DG,Negrão-Corrêa D,Teixeira MMdoi
10.1016/j.micinf.2008.11.015subject
Has Abstractpub_date
2009-02-01 00:00:00pages
315-20issue
2eissn
1286-4579issn
1769-714Xpii
S1286-4579(08)00315-8journal_volume
11pub_type
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