Abstract：
:Several observations suggest that inhibition of the host complement alternative pathway by Ixodes tick saliva is crucial to achieve blood feeding. We recently described two paralogous anti-complement proteins called Ixodes ricinus anti-complement (IRAC) proteins I and II co-expressed in I. ricinus salivary glands. Phylogenetic analyses suggested that these sequences were diversifying by a process of positive Darwinian selection, possibly leading to molecules with different biological properties. In the present study, we tested the hypothesis that each paralogue may have different inhibitory activities against the complement of different natural host species, thereby contributing to broaden the host range of I. ricinus ticks. IRAC I and IRAC II were tested against the complement of eight I. ricinus natural host species (six mammals and two birds). The results demonstrate that IRAC I and IRAC II have broad and complementary inhibition activities against the complement of different host species. This report is the first description of paralogous anti-complement molecules encoded by a pathogen with broad and complementary inhibitory activities against the complement of different host species.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Schroeder H,Daix V,Gillet L,Renauld JC,Vanderplasschen Adoi
10.1016/j.micinf.2006.10.020subject
Has Abstractpub_date
2007-02-01 00:00:00pages
247-50issue
2eissn
1286-4579issn
1769-714Xpii
S1286-4579(06)00383-2journal_volume
9pub_type
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journal_title：Microbes and infection
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