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Relationship between genome packaging and Gag translation/AUG of primate lentiviruses.

Abstract：

:About the relationship between retroviral genome packaging and translation, three possible modes (random-, trans-, and cis-) of packaging process could be assumed. In this report, we developed an assay system based on the RT-qPCR to measure the packaging efficiency of primate lentiviruses. With this system, we analyzed the genome packaging modes of primate lentiviruses such as HIV-1, 2, SIVmac and SIVagm. The data suggested that the modes of all viruses analyzed were very similar. In addition, we observed that the Gag-AUG sequences of them played important roles for maintaining efficient packaging, other than the initiation of translation.

journal_name

Microbes Infect

journal_title

Microbes and infection

authors

Sakuragi S,Shioda T,Sakuragi JI

doi

10.1016/j.micinf.2018.09.002

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

119-123

issue

2

eissn

1286-4579

issn

1769-714X

pii

S1286-4579(18)30151-5

journal_volume

21

pub_type

杂志文章

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