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Increased circulating procoagulant and anticoagulant factors as TF and TFPI according to severity or infecting serotypes in human dengue infection.

Abstract：

:Tissue Factor (TF) is the initiator of coagulation and Tissue Factor Inhibitor (TFPI) is the physiological inhibitor of the TF/FVIIa complex. Circulating levels of TF and TFPI were quantified in dengue patients and the relationships with disease severity and infecting serotype analysed. A significant decrease in TF and TPFI plasma levels was observed in mild DF patients compared with severe dengue. Furthermore, both factors were associated with haemorrhagic manifestations. Finally, TF levels were significantly increased in DENV-1/2 infected patients as compared with DENV-4. These findings suggest that activation of TF-pathway is an important component of DENV -related coagulation disorders.

journal_name

Microbes Infect

journal_title

Microbes and infection

authors

Leal de Azeredo E,Solórzano VE,de Oliveira DB,Marinho CF,de Souza LJ,da Cunha RV,Damasco PV,Kubelka CF,de-Oliveira-Pinto LM

doi

10.1016/j.micinf.2016.08.005

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

62-68

issue

1

eissn

1286-4579

issn

1769-714X

pii

S1286-4579(16)30121-6

journal_volume

19

pub_type

杂志文章

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