Abstract：
:Immature dendritic cells (Dcs) are characterised by high antigen uptake ability and poor T-cell stimulatory function. In contrast, mature DCs have a high stimulatory function and poor antigen uptake ability. Inflammatory stimuli induce DC maturation and migration from nonlymphoid tissues to lymphoid organs. We investigated the effect of lipopolysaccharide (LPS) on DC antigen uptake and migratory function at early and late stimulation time points. We observed that the transition from the immature to the mature state is not a progressive itinerary, but it is characterised by precise functional stages. At early time points after LPS stimulation DCs significantly decrease their intrinsic migratory ability and increase the antigen uptake function. Later, around 4 h after LPS activation, DCs show recovery of migratory ability and start to progressively lose their antigen uptake function until the mature stage in which they show poor antigen uptake and migratory activity.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Granucci F,Ferrero E,Foti M,Aggujaro D,Vettoretto K,Ricciardi-Castagnoli Pdoi
10.1016/s1286-4579(99)00209-9subject
Has Abstractpub_date
1999-11-01 00:00:00pages
1079-84issue
13eissn
1286-4579issn
1769-714Xpii
S1286-4579(99)00209-9journal_volume
1pub_type
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 信件
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journal_title：Microbes and infection
pub_type： 杂志文章
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journal_title：Microbes and infection
pub_type： 杂志文章
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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journal_title：Microbes and infection
pub_type： 杂志文章
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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更新日期：2001-08-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
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