Abstract：
:Infection of mice with Plasmodium berghei NK65 represents a well-recognized malaria model in which infection is accompanied by an intense hepatic inflammatory response. Enzyme-inducible nitric oxide synthase is an important regulator of inflammation and leukocyte recruitment in microvessels, but these functions have yet to be evaluated in experimental malaria. In this study, we assessed the involvement of inducible nitric oxide synthase in inflammatory responses to murine experimental malaria induced by P. berghei NK65. We observed that wild type (WT) and nitric oxide synthase (iNOS)-deficient mice (iNOS(-/-)) mice showed similar levels of parasitemia following P. berghei NK65 infection, although infected iNOS(-/-) mice presented early mortality. Inducible nitric oxide synthase deficiency led to increased leukocyte rolling and adhesion to the liver in iNOS(-/-) mice relative to the WT animals, as observed via intravital microscopy. Infected iNOS(-/-) mice also exhibited increased hepatic leukocyte migration and subsequent liver damage, which was associated with high serum levels of the cytokines TNF-α, IL-6 and IL-10. Our data suggest potential role for the iNOS enzyme as a regulator of hepatic inflammatory response induced by P. berghei NK65-infection, and its absence leads to exacerbated inflammation and sequential associated-hepatic damage in the animals.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Oliveira-Lima OC,Bernardes D,Xavier Pinto MC,Esteves Arantes RM,Carvalho-Tavares Jdoi
10.1016/j.micinf.2013.08.001subject
Has Abstractpub_date
2013-11-01 00:00:00pages
903-10issue
13eissn
1286-4579issn
1769-714Xpii
S1286-4579(13)00153-6journal_volume
15pub_type
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Microbes and infection
pub_type： 杂志文章
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更新日期：2011-08-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
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journal_title：Microbes and infection
pub_type： 杂志文章
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