Abstract：
:Autoantibodies against various components of host are known to occur in leprosy. Nerve damage is the primary cause of disability associated with leprosy. The aim of this study was to detect the level of autoantibodies and lympho-proliferative response against myelin basic protein (MBP) in leprosy patients (LPs) and their correlation with clinical phenotypes of LPs. Further, probable role of molecular mimicry in nerve damage of LPs was investigated. We observed significantly high level of anti-MBP antibodies in LPs across the spectrum and a positive significant correlation between the level of anti-MBP antibodies and the number of nerves involved in LPs. We report here that 4 B cell epitopes of myelin A1 and Mycobacterium leprae proteins, 50S ribosomal L2 and lysyl tRNA synthetase are cross-reactive. Further, M. leprae sonicated antigen hyperimmunization was responsible for induction of autoantibody response in mice which could be adoptively transferred to naive mice. For the first time our findings suggest the role of molecular mimicry in nerve damage in leprosy.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Singh I,Yadav AR,Mohanty KK,Katoch K,Sharma P,Mishra B,Bisht D,Gupta UD,Sengupta Udoi
10.1016/j.micinf.2014.12.015subject
Has Abstractpub_date
2015-04-01 00:00:00pages
247-57issue
4eissn
1286-4579issn
1769-714Xpii
S1286-4579(14)00337-2journal_volume
17pub_type
杂志文章abstract：:Attenuated Salmonella induce immunosuppressive, microbicidal and tumoricidal macrophages in mice. All three effects are mediated by activated macrophages producing nitric oxide (NO). NO is induced by the innate immune response pathway involving IL-12, NK cells and IFN-gamma in response to infection. NO has beneficial ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
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journal_title：Microbes and infection
pub_type： 杂志文章
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abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title：Microbes and infection
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abstract：:Toll-like receptors recognize specific patterns of microbial components and regulate the activation of both innate and adaptive immunity. TLR4 recognizes lipopolysaccharide (LPS) in monocytes/macrophages with the help of other molecules like CD14 and MD-2, which indicates that the functional LPS receptor forms a large...
journal_title：Microbes and infection
pub_type： 杂志文章
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journal_title：Microbes and infection
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2010.12.003
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.10.002
更新日期：2014-01-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2012.07.013
更新日期：2012-11-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2020.02.007
更新日期：2020-09-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.04.009
更新日期：2007-07-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.10.017
更新日期：2007-02-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2012.02.001
更新日期：2012-07-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2016.05.004
更新日期：2016-09-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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journal_title：Microbes and infection
pub_type： 杂志文章
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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更新日期：2000-07-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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更新日期：2004-01-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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更新日期：2006-04-01 00:00:00
abstract：:Control of human African trypanosomiasis (HAT) is highly dependent on the ability to detect and treat infected individuals. However, a number of individuals exposed to Trypanosoma brucei gambiense are able to control infection to undetectable levels in blood. They are long-term potential reservoirs and thus a threat f...
journal_title：Microbes and infection
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.12.007
更新日期：2007-03-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.05.006
更新日期：2015-09-01 00:00:00
abstract：:Salmonella, a Gram-negative facultative intracellular pathogen is capable of infecting vast array of hosts. The striking ability of Salmonella to overcome every hurdle encountered in the host proves that they are true survivors. In the host, Salmonella infects various cell types and needs to survive and replicate by c...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2010.05.010
更新日期：2010-10-01 00:00:00
abstract：:Amoebiasis is responsible for 50000-100000 deaths annually. Invasive amoebic disease begins with the attachment of Entamoeba histolytica trophozoites to colonic mucin, a process mediated by the amoebic Gal/GalNAc lectin. The non-pathogenic counterpart, E. dispar, is morphologically identical but genetically distinct. ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)01330-7
更新日期：2000-11-01 00:00:00
