Abstract：
:In human blood, promastigotes bind natural antibodies and activate the classical complement pathway. C3-opsonized promastigotes immune-adhere within seconds to erythrocytes. Promastigote lysis by complement parallels C3 deposition kinetics, and ~90% of promastigotes are killed after 2.5 min. During infection, complement thus exerts strong selective pressure on Leishmania. Paradoxically, promastigote adaptation to the host immune adherence mechanism may provide the parasite a key to invasion.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Domínguez M,Moreno I,Aizpurua C,Toraño Adoi
10.1016/s1286-4579(03)00071-6subject
Has Abstractpub_date
2003-05-01 00:00:00pages
507-13issue
6eissn
1286-4579issn
1769-714Xpii
S1286457903000716journal_volume
5pub_type
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