Abstract:
:Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. We also demonstrate that T. cruzi parasitizes primary adipocytes in vitro. Thus, in humans as in mice the parasite may persist in adipose tissue for decades and become a reservoir of infection.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Ferreira AV,Segatto M,Menezes Z,Macedo AM,Gelape C,de Oliveira Andrade L,Nagajyothi F,Scherer PE,Teixeira MM,Tanowitz HBdoi
10.1016/j.micinf.2011.06.002subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1002-5issue
12-13eissn
1286-4579issn
1769-714Xpii
S1286-4579(11)00147-Xjournal_volume
13pub_type
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journal_title:Microbes and infection
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