Abstract：
:Malaria is an infectious disease caused by parasites of the genus Plasmodium. This intraerythrocytic protozoan produces hemozoin (HZ), an insoluble crystalline metabolite resulting from the heme detoxification mechanism. This review will focus on HZ biosynthesis and synthetic preparation, but in particular on its effect on host's innate inflammatory responses.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Shio MT,Kassa FA,Bellemare MJ,Olivier Mdoi
10.1016/j.micinf.2010.07.001subject
Has Abstractpub_date
2010-11-01 00:00:00pages
889-99issue
12-13eissn
1286-4579issn
1769-714Xpii
S1286-4579(10)00176-0journal_volume
12pub_type
杂志文章,评审abstract：:Helicobacter pylori infection is highly prevalent in Chile (73%). Usually a minority of infected patients develops complications such as ulcers and gastric cancer that have been associated with the presence of virulence factors (cagA, vacA) and host T helper response (Th1/Th2). Our aim was to evaluate the relationship...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.12.012
更新日期：2007-04-01 00:00:00
abstract：:Moraxella catarrhalis has again been recognized as a significant pathogen. The past decade has witnessed an increased amount of research and understanding of the pathogenesis of the organism. This review will summarize the research pertaining to the epidemiology and components of pathogenesis in M. catarrhalis. ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)00314-2
更新日期：2000-04-01 00:00:00
abstract：:Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2005.12.001
更新日期：2006-04-01 00:00:00
abstract：:Novel vaccines are needed to control tuberculosis (TB), the bacterial infectious disease that together with malaria and HIV is worldwide responsible for high levels of morbidity and mortality. TB can result from the reactivation of an initially controlled latent infection by Mycobacterium tuberculosis (Mtb). Mtb prote...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2011.08.011
更新日期：2012-01-01 00:00:00
abstract：:Intramuscular immunization with DNA vaccines has been shown to induce a broad range of immune responses and protective immunity in many animal models, but it is less effective in primates. One reason for this may be the low expression of vector-encoded antigen in cells. Here we report that the use of vaccine vector (p...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.06.010
更新日期：2006-09-01 00:00:00
abstract：:Cryptosporidium parvum is an intracellular protozoan parasite that causes severe infection in humans and animals. The great difficulties in treating people and animals suffering from cryptosporidiosis have prompted the development of in vitro experimental models. The aim of this study was to demonstrate that C. parvum...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.02.016
更新日期：2004-05-01 00:00:00
abstract：:Purging HIV-1 to cure the infection in patients undergoing suppressive antiretroviral therapy requires targeting all possible viral reservoirs. Other than the memory CD4(+) T cells, several other HIV-1 reservoirs have been identified. HIV-1 infection in the brain as a reservoir is well documented, but not fully charac...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.05.006
更新日期：2015-09-01 00:00:00
abstract：:Multilocus enzyme electrophoresis (MLEE) is the gold standard for taxonomy and strain typing of Leishmania, but has some limitations. An alternative reliable and fast genotyping method for addressing population genetic and key epidemiological questions, is multilocus microsatellite typing (MLMT). MLMT using 15 markers...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.12.009
更新日期：2007-03-01 00:00:00
abstract：:The Chlamydia trachomatis genome encodes glycolysis and pentose phosphate pathway enzymes, two ATP/ADP exchange proteins, and other energy transduction-related components. We asked if and when chlamydial genes specifying products related to energy transduction are expressed during active vs. persistent infection in in...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(01)01504-0
更新日期：2002-01-01 00:00:00
abstract：:Surfactant protein C (SP-C) is a highly hydrophobic protein found in pulmonary surfactant. SP-C is synthesized exclusively in alveolar type II cells as a 21 kDa integral membrane precursor protein and subsequently proteolytically processed to a 3.7 kDa secretory protein. SP-C enhances the adsorption and spreading of p...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2006.04.009
更新日期：2006-07-01 00:00:00
abstract：:This study used a murine model of type 2 diabetes (BKS.Cg-Dock7(m) +/+Lepr(db)/J mice) to investigate the inflammatory and cellular mechanisms predisposing to Burkholderia pseudomallei infection and co-morbid diabetes. Homozygous db/db (diabetic) mice developed extreme obesity, dyslipidaemia and glucose intolerance le...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2011.07.008
更新日期：2011-12-01 00:00:00
abstract：:Lactic acid bacteria (LAB) show anti-inflammatory effects, and their genomic DNA was identified as one of the anti-inflammatory components. Despite the differences in anti-inflammatory effects between live LAB dependent not only on genus but also species, this effect has not been compared at the genomic DNA level. We ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2012.11.003
更新日期：2013-02-01 00:00:00
abstract：:Ebolavirus can cause a highly fatal and panic-generating human disease which may jump from bats to other mammals and human. High viral loads in body fluids allow efficient transmission by contact. Lack of effective antivirals, vaccines and public health infrastructures in parts of Africa make it difficult to health wo...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2014.11.007
更新日期：2015-02-01 00:00:00
abstract：:We examined various HIV-1 Vif mutants for interaction with APOBEC3 proteins (A3G/A3F). All replication-defective proviral mutants were found to carry A3G/A3F in virions, and of these, a replication-defective mutant with Vif that binds to A3G in cells but not in virions was noted. Furthermore, a mutant Vif protein that...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2009.11.007
更新日期：2010-02-01 00:00:00
abstract：:The early interferon-gamma (IFN-gamma) response after Salmonella infection was compared in resistant and susceptible congenic mice strains differing by the allele of Nramp1. IFN-gamma gene expression in vivo was studied by quantitative reverse transcription-PCR performed from the spleen of mice challenged by Salmonell...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(01)01419-8
更新日期：2001-07-01 00:00:00
abstract：:Pathogenic Leptospira species are the causative agents of leptospirosis, a global zoonotic infectious disease. Toxin-antitoxin (TA) modules have been confirmed as stress-response elements that induce prokaryotic and eukaryotic cell-growth arrest or death, but their role in the virulence of Leptospira has not been repo...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2014.10.010
更新日期：2015-01-01 00:00:00
abstract：:While the Vif protein of human immunodeficiency virus type 1 (HIV-1) is essential for viral replication in non-permissive cells, it is rapidly degraded intracellularly. We have previously suggested that the rapid turn-over of Vif is biologically meaningful to prevent detrimental effects of this protein at high express...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.04.011
更新日期：2004-07-01 00:00:00
abstract：:About the relationship between retroviral genome packaging and translation, three possible modes (random-, trans-, and cis-) of packaging process could be assumed. In this report, we developed an assay system based on the RT-qPCR to measure the packaging efficiency of primate lentiviruses. With this system, we analyze...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2018.09.002
更新日期：2019-03-01 00:00:00
abstract：:Tissue Factor (TF) is the initiator of coagulation and Tissue Factor Inhibitor (TFPI) is the physiological inhibitor of the TF/FVIIa complex. Circulating levels of TF and TFPI were quantified in dengue patients and the relationships with disease severity and infecting serotype analysed. A significant decrease in TF an...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2016.08.005
更新日期：2017-01-01 00:00:00
abstract：:Campylobacter jejuni is the predominant cause of antecedent infection in Guillain-Barré syndrome (GBS) or Miller Fisher syndrome (MFS). C. jejuni probably triggers GBS or MFS through molecular mimicry between bacterial sialylated lipo-oligosaccharides (LOS) and gangliosides in peripheral nerve tissue. We investigated ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.06.022
更新日期：2006-01-01 00:00:00
abstract：:The iron-limitation-inducible protein FrpB of Neisseria meningitidis is an outer-membrane-localized siderophore receptor. Because of its abundance and its capacity to elicit bactericidal antibodies, it is considered a vaccine candidate. Bactericidal antibodies against FrpB are, however, type-specific. Hence, an FrpB-b...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.04.011
更新日期：2006-07-01 00:00:00
abstract：:Intensive care unit (ICU)-acquired lower respiratory tract infections include acute tracheobronchitis and hospital-acquired and ventilator-associated pneumonia (VAP). Nosocomial pneumonia is the second most common hospital-acquired infection and the leading cause of death in hospital-acquired infections. The mortality...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.12.001
更新日期：2005-02-01 00:00:00
abstract：:Phocid herpesvirus virus type 2 (PhHV-2), a putative gammaherpesvirus of seals, has been isolated from harbor seals (Phoca vitulina) and grey seals (Halichoerus grypus). In the present study, different PhHV-2 isolates were shown to have a broad in vitro tropism for various cell types from several mammalian species. In...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.10.006
更新日期：2007-01-01 00:00:00
abstract：:Innate lymphoid cells (ILCs) are the innate counterpart of T cells. Upon infection or injury, ILCs react promptly to direct the developing immune response to the one most adapted to the threat facing the organism. Therefore, ILCs play an important role early in resistance to infection, but also to maintain homeostasis...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2018.05.003
更新日期：2018-01-01 00:00:00
abstract：:Major advances have recently been achieved in the area of microbial recognition by the innate immune system. In this Forum, we discuss important issues related to innate recognition of bacteria and protozoan parasites. In particular, we highlight the structural characterization of pathogen-associated molecular pattern...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01625-8
更新日期：2002-07-01 00:00:00
abstract：:To survive macrophage killing is critical in the pathogenesis of viridians streptococci-induced infective endocarditis (IE). Streptococcus mutans, an opportunistic IE pathogen, generally does not survive well phagocytic killing in murine macrophage RAW 264.7 cells. A putative two-component system (TCS), ScnR/ScnK from...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.12.006
更新日期：2008-03-01 00:00:00
abstract：:This review considers whether the products of schistosomes in the mammalian host can be considered as virulence factors. These include: the cercarial secretions used in infection, those of the migrating schistosomulum, surface-exposed proteins of adult worms in the portal system and their gut vomitus in the context of...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2012.09.001
更新日期：2012-12-01 00:00:00
abstract：:The vif gene of human immunodeficiency virus type 1 (HIV-1) is essential for virus growth in non-permissive cells such as H9. To elucidate the mechanism of action of the Vif protein, vif mutants, which show trans-dominant negative effects on the replication of HIV-1, would be useful tools. In this study, a new assay s...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(02)01646-5
更新日期：2002-10-01 00:00:00
abstract：:Staphylococcus aureus is a major cause of hospital-acquired infections. The ability to survive on abiotic surfaces is an important characteristic that facilitates transmission between human hosts. We found that S. aureus survivors of dry surface incubation are resistant to subsequent dry stress exposure. Survivors als...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.02.004
更新日期：2015-06-01 00:00:00
abstract：:BCG rectal administration to newborn and adult mice induced protective immune responses against tuberculosis. BCG reaches the sub-epithelial site and the draining mesenteric lymph nodes (MLNs), and dendritic cells (DC) could be recruited to these sites. Using polarized Caco-2 epithelial cells, we showed that BCG trans...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.03.022
更新日期：2006-08-01 00:00:00
