Control of pathogens and microbiota by innate lymphoid cells.

Abstract:

:Innate lymphoid cells (ILCs) are the innate counterpart of T cells. Upon infection or injury, ILCs react promptly to direct the developing immune response to the one most adapted to the threat facing the organism. Therefore, ILCs play an important role early in resistance to infection, but also to maintain homeostasis with the symbiotic microbiota following perturbations induced by diet and pathogens. Such roles of ILCs have been best characterized in the intestine and lung, mucosal sites that are exposed to the environment and are therefore colonized with diverse but specific types of microbes. Understanding the dialogue between pathogens, microbiota and ILCs may lead to new strategies to re-inforce immunity for prevention, vaccination and therapy.

journal_name

Microbes Infect

journal_title

Microbes and infection

authors

Cording S,Medvedovic J,Lecuyer E,Aychek T,Eberl G

doi

10.1016/j.micinf.2018.05.003

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

317-322

issue

6

eissn

1286-4579

issn

1769-714X

pii

S1286-4579(18)30109-6

journal_volume

20

pub_type

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