Abstract:
:Paracoccidioidomycosis is a systemic mycosis endemic to Latin America. The infection is initiated by inhalation of conidia into the lung and may develop as localized or disseminated disease depending on the depression of cellular immunity. In the present study, we observed that intratracheal infection with Paracoccidioides brasiliensis caused the percentage of resident B-1 cells to decrease. Using xid mice reconstituted with B-1 cells, we observed that B-1 cells migrate to the spleen and stimulate increases in the regulatory T cell subpopulation in response to P. brasiliensis infection. Collectively, these data demonstrate an active role for B-1 cells in susceptibility to paracoccidioidomycosis.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Noal V,Santos S,Ferreira KS,Almeida SRdoi
10.1016/j.micinf.2016.08.001subject
Has Abstractpub_date
2016-12-01 00:00:00pages
798-803issue
12eissn
1286-4579issn
1769-714Xpii
S1286-4579(16)30103-4journal_volume
18pub_type
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