当前位置： SCI文献检索 > MICROBES AND INFECTION期刊下所有文献 > Chlamydia pneumoniae modulates human monocyte-derived dendritic cells functions driving the induction of a Type 1/Type 17 inflammatory response.

Chlamydia pneumoniae modulates human monocyte-derived dendritic cells functions driving the induction of a Type 1/Type 17 inflammatory response.

Abstract：

:Chlamydia pneumoniae is a respiratory pathogen involved in the onset of chronic inflammatory pathologies. Dendritic cells (DC), are major players in spreading of C. pneumoniae from the lungs, a crucial step leading to disseminated infections. Less is known concerning modulation of DC functions consequent to encounter with the bacterium. In order to address this aspect, human monocyte-derived (MD)DC were infected with C. pneumoniae. After internalization bacterial counts increased in MDDC, as well as the expression of CPn1046, a gene involved in bacterial metabolism, with a peak 48 h after the infection. Infected MDDC switched to the mature stage, produced IL-12p70, IL-1β, IL-6, and IL-10, and drove a mixed Type 1/Type 17 polarization. Intracellular pathways triggered by C. pneumoniae involved Toll-like receptor (TLR) 2. Indeed, TLR2 was activated by C. pneumoniae in transfected HEK 293 cells, and C. pneumoniae-mediated phosphorylation of ERK1/2 was inhibited by an anti-TLR2 antibody in MDDC. When an ERK1/2 inhibitor was used, IL-12p70 and IL-10 release by MDDC was reduced and T cell polarization shifted towards a Type 2 profile. Overall, our findings unveiled the role played by TLR2 and ERK1/2 induced by C. pneumoniae to affect DC functions in a way that contributes to a Type 1/Type 17 pro-inflammatory response.

journal_name

Microbes Infect

journal_title

Microbes and infection

authors

Flego D,Bianco M,Quattrini A,Mancini F,Carollo M,Schiavoni I,Ciervo A,Ausiello CM,Fedele G

doi

10.1016/j.micinf.2012.11.004

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

105-14

issue

2

eissn

1286-4579

issn

1769-714X

pii

S1286-4579(12)00275-4

journal_volume

15

pub_type

杂志文章

相关文献

MICROBES AND INFECTION文献大全
  • IRE1α mediates PKR activation in response to Chlamydia trachomatis infection.

    abstract：:Protein kinase RNA activated (PKR) is a crucial mediator of anti-viral responses but is reported to be activated by multiple non-viral stimuli. However, mechanisms underlying PKR activation, particularly in response to bacterial infection, remain poorly understood. We have investigated mechanisms of PKR activation in ...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2016.03.010

    authors： Webster SJ,Ellis L,O'Brien LM,Tyrrell B,Fitzmaurice TJ,Elder MJ,Clare S,Chee R,Gaston JS,Goodall JC

    更新日期：2016-07-01 00:00:00

  • Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease.

    abstract：:Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. ...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2011.06.002

    authors： Ferreira AV,Segatto M,Menezes Z,Macedo AM,Gelape C,de Oliveira Andrade L,Nagajyothi F,Scherer PE,Teixeira MM,Tanowitz HB

    更新日期：2011-11-01 00:00:00

  • ChpK and MazF of the toxin-antitoxin modules are involved in the virulence of Leptospira interrogans during infection.

    abstract：:Pathogenic Leptospira species are the causative agents of leptospirosis, a global zoonotic infectious disease. Toxin-antitoxin (TA) modules have been confirmed as stress-response elements that induce prokaryotic and eukaryotic cell-growth arrest or death, but their role in the virulence of Leptospira has not been repo...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2014.10.010

    authors： Komi KK,Ge YM,Xin XY,Ojcius DM,Sun D,Hu WL,Zhao X,Lin X,Yan J

    更新日期：2015-01-01 00:00:00

  • Characterization of apoptosis induced by sorbitol: a unique system for the detection of antiapoptotic activities of viruses.

    abstract：:The treatment of HEp-2 cells with sorbitol induced massive apoptosis rapidly. This method for inducing apoptosis is very useful to detect antiapoptotic activity of viruses as well as viral genes. Commitment to death occurred immediately upon incubation with sorbitol, even in the presence of pancaspase inhibitor, Z-VAD...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/s1286-4579(00)00366-x

    authors： Koyama AH,Arakawa T,Adachi A

    更新日期：2000-05-01 00:00:00

  • Role of complement in host defense against bacterial infection.

    abstract：:This short review will highlight three areas of current research on the role of complement in bacterial infection. These are i) the use of mice with targeted disruption of complement genes to study infectious disease models; ii) studies on the interactions between bacterial virulence factors and complement regulatory ...

    journal_title：Microbes and infection

    pub_type： 杂志文章,评审

    doi：10.1016/s1286-4579(99)80063-x

    authors： Mold C

    更新日期：1999-07-01 00:00:00

  • B-1 cells upregulate CD8 T lymphocytes and increase proinflammatory cytokines serum levels in oral encephalitozoonosis.

    abstract：:Microsporidia are intracellular pathogens that cause severe disease in immunocompromised humans and animals. We recently demonstrated that XID mice are more susceptible to Encephalitozoon cuniculi infection by intraperitoneal route, evidencing the role of B-1 cells in resistance against infection. The present study in...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2017.11.004

    authors： Langanke Dos Santos D,Alvares-Saraiva AM,Xavier JG,Spadacci-Morena DD,Peres GB,Dell'Armelina Rocha PR,Perez EC,Lallo MA

    更新日期：2018-03-01 00:00:00

  • Severe pneumonia due to Parachlamydia acanthamoebae following intranasal inoculation: a mice model.

    abstract：:Parachlamydia acanthamoebae is an obligate intracellular bacterium naturally infecting free-living amoebae. The role of this bacterium as an agent of pneumonia is suggested by sero-epidemiological studies and molecular surveys. Furthermore, P. acanthamoebae may escape macrophages microbicidal effectors. Recently, we d...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2015.08.007

    authors： Pilloux L,Casson N,Sommer K,Klos A,Stehle JC,Pusztaszeri M,Greub G

    更新日期：2015-11-01 00:00:00

  • Pathogenic conversion of coagulase-negative staphylococci.

    abstract：:Humans and animals are colonized by members of the genus Staphylococcus, however only some of these species evolved to cause invasive disease. The genetic basis for conversion of commensal staphylococci into pathogens is not known. We hypothesized that Staphylococcus aureus genes for coagulation and agglutination in v...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2016.12.002

    authors： Yu W,Kim HK,Rauch S,Schneewind O,Missiakas D

    更新日期：2017-02-01 00:00:00

  • Sending signals - The microbiota's contribution to intestinal epithelial homeostasis.

    abstract：:The intestine is inhabited by a diverse range of microorganisms, which requires the host to employ numerous barrier measures to prevent bacterial invasion. However, the intestinal microbiota additionally acts symbiotically with host cells to maintain epithelial barrier function, and perturbation to this interaction pl...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2020.10.009

    authors： Goyal S,Tsang DKL,Maisonneuve C,Girardin SE

    更新日期：2020-11-12 00:00:00

  • Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2.

    abstract：:Macrophage-activating lipopeptide 2 (MALP-2), a mycoplasmal diacylated lipopeptide with palmitic acid moiety (Pam2), activates Toll-like receptor (TLR) 2 to induce inflammatory cytokines. TLR2 is known to mature myeloid dendritic cells (mDC) to drive mDC contact-mediated natural killer (NK) cell activation. Here we te...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2010.12.003

    authors： Sawahata R,Shime H,Yamazaki S,Inoue N,Akazawa T,Fujimoto Y,Fukase K,Matsumoto M,Seya T

    更新日期：2011-04-01 00:00:00

  • Potential effect of cattle diets on the transmission of pathogenic Escherichia coli to humans.

    abstract：:Grain feeding seems to promote the growth and acid resistance of Escherichia coli in fattening beef cattle, and acid-resistant E. coli are more likely to survive the human gastric stomach. When cattle were fed hay for only five days, the number and acid resistance of E. coli decreased dramatically. ...

    journal_title：Microbes and infection

    pub_type： 杂志文章,评审

    doi：10.1016/s1286-4579(00)00286-0

    authors： Russell JB,Diez-Gonzalez F,Jarvis GN

    更新日期：2000-01-01 00:00:00

  • Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex.

    abstract：:Kinins, the vasoactive peptides proteolytically liberated from kininogens, were recently recognized as signals alerting the innate immune system. Here we demonstrate that Leishmania donovani and Leishmania chagasi, two etiological agents of visceral leishmaniasis (VL), activate the kinin system. Intravital microscopy ...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2005.06.016

    authors： Svensjö E,Batista PR,Brodskyn CI,Silva R,Lima AP,Schmitz V,Saraiva E,Pesquero JB,Mori MA,Müller-Esterl W,Scharfstein J

    更新日期：2006-01-01 00:00:00

  • Molecular mimicry between Mycobacterium leprae proteins (50S ribosomal protein L2 and Lysyl-tRNA synthetase) and myelin basic protein: a possible mechanism of nerve damage in leprosy.

    abstract：:Autoantibodies against various components of host are known to occur in leprosy. Nerve damage is the primary cause of disability associated with leprosy. The aim of this study was to detect the level of autoantibodies and lympho-proliferative response against myelin basic protein (MBP) in leprosy patients (LPs) and th...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2014.12.015

    authors： Singh I,Yadav AR,Mohanty KK,Katoch K,Sharma P,Mishra B,Bisht D,Gupta UD,Sengupta U

    更新日期：2015-04-01 00:00:00

  • The overlapping host responses to bacterial cyclic dinucleotides.

    abstract：:Macrophages respond to infection with Legionella pneumophila by the induction of inflammatory mediators, including type I Interferons (IFN-Is). To explore whether the bacterial second messenger cyclic 3'-5' diguanylate (c-diGMP) activates some of these mediators, macrophages were infected with L. pneumophila strains i...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2011.09.002

    authors： Abdul-Sater AA,Grajkowski A,Erdjument-Bromage H,Plumlee C,Levi A,Schreiber MT,Lee C,Shuman H,Beaucage SL,Schindler C

    更新日期：2012-02-01 00:00:00

  • Role of interferon-gamma in Valpha14+ natural killer T cell-mediated host defense against Streptococcus pneumoniae infection in murine lungs.

    abstract：:Previously, we demonstrated that Valpha14+ NKT cells and IFN-gamma are important upstream components in neutrophil-mediated host defense against infection with Streptococcus pneumoniae. In the present study, we extended these findings by elucidating the role of IFN-gamma in this Valpha14+ NKT cell-promoted process. Ad...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2006.12.003

    authors： Nakamatsu M,Yamamoto N,Hatta M,Nakasone C,Kinjo T,Miyagi K,Uezu K,Nakamura K,Nakayama T,Taniguchi M,Iwakura Y,Kaku M,Fujita J,Kawakami K

    更新日期：2007-03-01 00:00:00

  • TRAF activation of C/EBPbeta (NF-IL6) via p38 MAPK induces HIV-1 gene expression in monocytes/macrophages.

    abstract：:C/EBPbeta plays a pivotal role in activation of human immunodeficiency virus type 1 (HIV-1) in monocytes/macrophages. However, mechanisms for functional regulation of C/EBPbeta remain uncharacterized. Previous studies indicated that NF-kappaB activation by tumor necrosis factor (TNF) receptor family, which activates T...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2007.02.017

    authors： Horie R,Ishida T,Maruyama-Nagai M,Ito K,Watanabe M,Yoneyama A,Higashihara M,Kimura S,Watanabe T

    更新日期：2007-05-01 00:00:00

  • Toxoplasma IgG and IgA, but not IgM, antibody titers increase in sera of immunocompetent mice in association with proliferation of tachyzoites in the brain during the chronic stage of infection.

    abstract：:Toxoplasma IgG and IgA, but not IgM, antibody titers were significantly higher in immunocompetent mice with cerebral proliferation of tachyzoites during the chronic stage of infection than those treated with sulfadiazine to inhibit the parasite growth. Their IgG and IgA antibody titers correlated significantly with th...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2010.07.016

    authors： Singh J,Graniello C,Ni Y,Payne L,Sa Q,Hester J,Shelton BJ,Suzuki Y

    更新日期：2010-12-01 00:00:00

  • Genomic signature analysis of the recently emerged highly pathogenic A(H5N8) avian influenza virus: implying an evolutionary trend for bird-to-human transmission.

    abstract：:In early 2014, a novel subclade (2.3.4.4) of the highly pathogenic avian influenza (HPAI) A(H5N8) virus caused the first outbreak in domestic ducks and migratory birds in South Korea. Since then, it has spread to 44 countries and regions. To date, no human infections with A(H5N8) virus have been reported, but the poss...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2017.08.006

    authors： Xu W,Dai Y,Hua C,Wang Q,Zou P,Deng Q,Jiang S,Lu L

    更新日期：2017-12-01 00:00:00

  • Non-toxigenic tox gene-bearing Corynebacterium ulcerans in a traumatic ulcer from a human case and his asymptomatic dog.

    abstract：:A non-toxigenic tox gene-bearing (NTTB) Corynebacterium ulcerans was grown from the wound of a 61-year-old gardener and in a nasal specimen from the patient's asymptomatic dog. The two isolates were similar in terms of antibiogram, multilocus sequence typing (ST341), virulence genes, and only three SNPs were found to ...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2015.07.004

    authors： Fuursted K,Søes LM,Crewe BT,Stegger M,Andersen PS,Christensen JJ

    更新日期：2015-10-01 00:00:00

  • Potential of Mycobacterium tuberculosis resuscitation-promoting factors as antigens in novel tuberculosis sub-unit vaccines.

    abstract：:Novel vaccines are needed to control tuberculosis (TB), the bacterial infectious disease that together with malaria and HIV is worldwide responsible for high levels of morbidity and mortality. TB can result from the reactivation of an initially controlled latent infection by Mycobacterium tuberculosis (Mtb). Mtb prote...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2011.08.011

    authors： Romano M,Aryan E,Korf H,Bruffaerts N,Franken CL,Ottenhoff TH,Huygen K

    更新日期：2012-01-01 00:00:00

  • Evaluation of the protective immune response induced in mice by immunization with Schistosoma mansoni schistosomula tegument (Smteg) in association with CpG-ODN.

    abstract：:In schistosomiasis, the current control strategy does not prevent reinfection, therefore, vaccine strategies are essential to combat the Schistosoma mansoni. The efficacy vaccine depends on parasite stage and effective adjuvant. We have recently demonstrated that S. mansoni schistosomula tegument (Smteg) is able to ac...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2012.10.007

    authors： Teixeira de Melo T,Araujo JM,Campos de Sena I,Carvalho Alves C,Araujo N,Toscano Fonseca C

    更新日期：2013-01-01 00:00:00

  • Influence of leishmanolysin-like molecules of Herpetomonas samuelpessoai on the interaction with macrophages.

    abstract：:Monoxenous trypanosomatids usually have an invertebrate as the only host in their life cycles, however, they have been found repeatedly in plants and/or mammals. To succeed in colonizing a vertebrate host, the parasite must quickly adapt to drastic changes in the environment (e.g. temperature), which reflect the condi...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2010.07.010

    authors： Pereira FM,Santos-Mallet JR,Branquinha MH,d'Avila-Levy CM,Santos AL

    更新日期：2010-11-01 00:00:00

  • Rats, cats, people and parasites: the impact of latent toxoplasmosis on behaviour.

    abstract：:The manipulation hypothesis states a parasite may alter host behaviour for its own benefit, often by enhancing its transmission rate through the food chain. This paper reviews studies on the potential impact of one parasite, Toxoplasma gondii, on host behaviour, both on rodents, where altered responses may be proposed...

    journal_title：Microbes and infection

    pub_type： 杂志文章,评审

    doi：10.1016/s1286-4579(01)01459-9

    authors： Webster JP

    更新日期：2001-10-01 00:00:00

  • Endocrine modulation of Brucella abortus-infected osteocytes function and osteoclastogenesis via modulation of RANKL/OPG.

    abstract：:Osteoarticular brucellosis is the most frequent complication of active disease. A large amount of cells in bone are osteocytes. Since bone remodeling process is regulated by hormones we sought to study the effect of cortisol and DHEA in Brucella abortus-infected osteocytes. Cortisol treatment inhibited the expression ...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2019.01.004

    authors： Pesce Viglietti AI,Giambartolomei GH,Delpino MV

    更新日期：2019-01-01 00:00:00

  • A comparison of Anopheles gambiae and Plasmodium falciparum genetic structure over space and time.

    abstract：:Population genetic structure and subdivision are key factors affecting the evolution of organisms. In this study, we analysed and compared the population genetic structure of the malaria parasite Plasmodium falciparum and its mosquito vector Anopheles gambiae over space and time in the Nianza Province, near Victoria L...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2007.12.021

    authors： Prugnolle F,Durand P,Jacob K,Razakandrainibe F,Arnathau C,Villarreal D,Rousset F,de Meeûs T,Renaud F

    更新日期：2008-03-01 00:00:00

  • Expression of HIV-1 accessory protein Vif is controlled uniquely to be low and optimal by proteasome degradation.

    abstract：:While the Vif protein of human immunodeficiency virus type 1 (HIV-1) is essential for viral replication in non-permissive cells, it is rapidly degraded intracellularly. We have previously suggested that the rapid turn-over of Vif is biologically meaningful to prevent detrimental effects of this protein at high express...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2004.04.011

    authors： Fujita M,Akari H,Sakurai A,Yoshida A,Chiba T,Tanaka K,Strebel K,Adachi A

    更新日期：2004-07-01 00:00:00

  • Human cytomegalovirus infection reduces surface CCR5 expression in human microglial cells, astrocytes and monocyte-derived macrophages.

    abstract：:Within the brain, glial cells are target cells for human cytomegalovirus (HCMV) and HIV. We infected cultures of unstimulated human microglial cells and astrocytes of embryonic origin and of monocyte-derived macrophages (MDM) with HCMV strain AD169 and observed down-regulation of the plasma membrane expression of CCR5...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/s1286-4579(02)00022-9

    authors： Lecointe D,Dugas N,Leclerc P,Hery C,Delfraissy JF,Tardieu M

    更新日期：2002-11-01 00:00:00

  • Binding of Haemophilus ducreyi to carbohydrate receptors is mediated by the 58.5-kDa GroEL heat shock protein.

    abstract：:The bacterium Haemophilus ducreyi causes the sexually transmitted disease chancroid, which is characterized by the appearance of mucocutaneous, persistent ulcers on the external genitals. To identify carbohydrate receptors that mediate the attachment of this pathogen to host cells, we investigated the binding of 35S-m...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2006.05.009

    authors： Pantzar M,Teneberg S,Lagergård T

    更新日期：2006-08-01 00:00:00

  • Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritis.

    abstract：:Matrix metalloproteinases constitute a family of structurally related endopeptidases that are crucial for the normal turnover of the extracellular matrix. Elevated levels of MMP-9 have been demonstrated in synovial fluids of rheumatoid arthritis patients, and a correlation with the severity of the disease has been des...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2006.01.001

    authors： Calander AM,Starckx S,Opdenakker G,Bergin P,Quiding-Järbrink M,Tarkowski A

    更新日期：2006-05-01 00:00:00

  • Brucella lipoproteins mimic dendritic cell maturation induced by Brucella abortus.

    abstract：:Infection with Brucella abortus induces a pro-inflammatory response that drives T cell responses toward a Th1 profile. The mechanism by which this bacterium triggers this response is unknown. Dendritic cells (DC) are crucial mediators at the host-pathogen interface and are potent Th1-inducing antigen-presenting cells....

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2008.07.035

    authors： Zwerdling A,Delpino MV,Barrionuevo P,Cassataro J,Pasquevich KA,García Samartino C,Fossati CA,Giambartolomei GH

    更新日期：2008-10-01 00:00:00