The overlapping host responses to bacterial cyclic dinucleotides.

Abstract:

:Macrophages respond to infection with Legionella pneumophila by the induction of inflammatory mediators, including type I Interferons (IFN-Is). To explore whether the bacterial second messenger cyclic 3'-5' diguanylate (c-diGMP) activates some of these mediators, macrophages were infected with L. pneumophila strains in which the levels of bacterial c-diGMP had been altered. Intriguingly, there was a positive correlation between c-diGMP levels and IFN-I expression. Subsequent studies with synthetic derivatives of c-diGMP, and newly described cyclic 3'-5' diadenylate (c-diAMP), determined that these molecules activate overlapping inflammatory responses in human and murine macrophages. Moreover, UV crosslinking studies determined that both dinucleotides physically associate with a shared set of host proteins. Fractionation of macrophage extracts on a biotin-c-diGMP affinity matrix led to the identification of a set of candidate host binding proteins. These studies suggest that mammalian macrophages can sense and mount a specific inflammatory response to bacterial dinucleotides.

journal_name

Microbes Infect

journal_title

Microbes and infection

authors

Abdul-Sater AA,Grajkowski A,Erdjument-Bromage H,Plumlee C,Levi A,Schreiber MT,Lee C,Shuman H,Beaucage SL,Schindler C

doi

10.1016/j.micinf.2011.09.002

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

188-97

issue

2

eissn

1286-4579

issn

1769-714X

pii

S1286-4579(11)00234-6

journal_volume

14

pub_type

杂志文章
  • Immunogenicity and structural characterisation of an in vitro folded meningococcal siderophore receptor (FrpB, FetA).

    abstract::The iron-limitation-inducible protein FrpB of Neisseria meningitidis is an outer-membrane-localized siderophore receptor. Because of its abundance and its capacity to elicit bactericidal antibodies, it is considered a vaccine candidate. Bactericidal antibodies against FrpB are, however, type-specific. Hence, an FrpB-b...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2006.04.011

    authors: Kortekaas J,Müller SA,Ringler P,Gregorini M,Weynants VE,Rutten L,Bos MP,Tommassen J

    更新日期:2006-07-01 00:00:00

  • The innate immune response to Aspergillus fumigatus.

    abstract::Despite the development of new treatments, the mortality due to invasive pulmonary aspergillosis remains above 50%, reaching 95% in certain situations. The battle against Aspergillus fumigatus involves several components of the pulmonary innate immune system: cells, mediators, and natural antifungal molecules involved...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审

    doi:10.1016/j.micinf.2009.07.002

    authors: Balloy V,Chignard M

    更新日期:2009-10-01 00:00:00

  • Regulation of the generation and maintenance of T-cell memory: a direct, default pathway from effectors to memory cells.

    abstract::Memory T cells are derived directly from effector cells without need for additional antigen, TcR triggering or induced cytokines. A large fraction of effectors can become memory cells without division, supporting a default pathway with little further differentiation. This suggests that the same signals during infectio...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审

    doi:10.1016/s1286-4579(03)00013-3

    authors: Swain SL

    更新日期:2003-03-01 00:00:00

  • The Anopheles gambiae cE5 salivary protein: a sensitive biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control.

    abstract::Evaluation of vector control is crucial for improving malaria containment and, according to World Health Organization, new complementary indicators would be very valuable. In this study the IgG response to the Anopheles-specific cE5 salivary protein was tested as a tool to evaluate the efficacy of insecticide-treated ...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2015.01.002

    authors: Marie A,Ronca R,Poinsignon A,Lombardo F,Drame PM,Cornelie S,Besnard P,Le Mire J,Fiorentino G,Fortes F,Carnevale P,Remoue F,Arcà B

    更新日期:2015-06-01 00:00:00

  • Protective immunity and delayed type hypersensitivity reaction are uncoupled in experimental Leishmania major infection of CCR6-negative mice.

    abstract::The chemokine receptor CCR6 is expressed on naïve B cells, dendritic cell and T-cell subpopulations and is involved in cell navigation during organogenesis and recruitment in response to inflammatory stimuli. Gene-deficient C57BL/6 CCR6(-/-) mice infected with the protozoan parasite Leishmania (L.) major were able to ...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2006.12.002

    authors: Lechner A,Ritter U,Varona R,Marquez G,Bogdan C,Körner H

    更新日期:2007-03-01 00:00:00

  • A recombinant vesicular stomatitis virus encoding CCR5-tropic HIV-1 receptors targets HIV-1-infected cells and controls HIV-1 infection.

    abstract::Anti-retroviral therapy is useful to treat human immunodeficiency virus type 1 (HIV-1)-infected individuals, but has some major problems, such as the generation of multidrug-resistant viruses. To develop a novel supplemental or alternative therapeutic for CCR5-tropic (R5) HIV-1 infection, we generated a recombinant ve...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2016.12.004

    authors: Okuma K,Fukagawa K,Kohma T,Takahama Y,Hamaguchi Y,Ito M,Tanaka Y,Buonocore L,Rose JK,Hamaguchi I

    更新日期:2017-01-01 00:00:00

  • Selection of HLA-B57-associated Gag A146P mutant by HLA-B∗48:01-restricted Gag140-147-specific CTLs in chronically HIV-1-infected Japanese.

    abstract::We previously showed the possibility that Gag A146P, which is an escape mutant from HLA-B∗57-restricted CTLs, was selected by HLA-B∗48:01-restricted Gag138-147(LI10)-specific CTLs in a Japanese cohort in which HLA-B∗57 individuals were not detected. We herein demonstrated Gag140-147(GI8) to be the optimal epitope rath...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2011.03.009

    authors: Naruto T,Murakoshi H,Chikata T,Koyanagi M,Kawashima Y,Gatanaga H,Oka S,Takiguchi M

    更新日期:2011-08-01 00:00:00

  • Temperature-mediated heteroduplex analysis for the detection of drug-resistant gene mutations in clinical isolates of Mycobacterium tuberculosis by denaturing HPLC, SURVEYOR nuclease.

    abstract::Denaturing high-performance liquid chromatography (DHPLC) is a relatively new technique, which utilizes heteroduplex formation between wild-type and mutated DNA strands to identify point mutations. Heteroduplex molecules are separated from homoduplex molecules by ion-pair, reverse-phase liquid chromatography on a spec...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2005.06.008

    authors: Shi R,Otomo K,Yamada H,Tatsumi T,Sugawara I

    更新日期:2006-01-01 00:00:00

  • IL-7 and IL-15 do not synergize during CD8 T cell recall response against an obligate intracellular parasite.

    abstract::Long-term protection against Toxoplasma gondii is dependent on robust CD8(+) T cell immunity. In the absence of this response, the host is unable to maintain chronicity, which results in recrudescence of infection and possible death. Factors needed for the persistence of protective CD8(+) T cells against the parasite ...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2012.07.018

    authors: Bhadra R,Khan IA

    更新日期:2012-11-01 00:00:00

  • Adherence and intracellular parasitism of Paracoccidioides brasiliensis in Vero cells.

    abstract::Paracoccidioides brasiliensis is a dimorphic fungus known to produce invasive systemic disease in humans. The 43-kDa glycoprotein of P. brasiliensis is the major diagnostic antigen of paracoccidioidomycosis and may act as a virulence factor, since it is a receptor for laminin.Very little is known about early interacti...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/s1286-4579(00)00390-7

    authors: Hanna SA,Monteiro da Silva JL,Giannini MJ

    更新日期:2000-07-01 00:00:00

  • Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex.

    abstract::Kinins, the vasoactive peptides proteolytically liberated from kininogens, were recently recognized as signals alerting the innate immune system. Here we demonstrate that Leishmania donovani and Leishmania chagasi, two etiological agents of visceral leishmaniasis (VL), activate the kinin system. Intravital microscopy ...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2005.06.016

    authors: Svensjö E,Batista PR,Brodskyn CI,Silva R,Lima AP,Schmitz V,Saraiva E,Pesquero JB,Mori MA,Müller-Esterl W,Scharfstein J

    更新日期:2006-01-01 00:00:00

  • Culture-attenuated pathogenic Leptospira lose the ability to survive to complement-mediated-killing due to lower expression of factor H binding proteins.

    abstract::Several pathogens including Gram-negative bacteria hijack complement regulators to escape host's innate response. Pathogenic Leptospira species bind Factor H, C4b binding protein and vitronectin from the complement system. We evaluated the ability of low passage (LP) and culture-attenuated (CA) pathogenic strains of L...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2019.03.001

    authors: Moreno-Torres A,Malvido-Jiménez IR,de la Peña-Moctezuma A,Castillo Sánchez LO,Fraga TR,Barbosa AS,Isaac L,Sahagún-Ruiz A

    更新日期:2019-01-01 00:00:00

  • Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and Wolbachia endobacteria.

    abstract::Onchocerca volvulus is a tissue-invasive parasitic nematode causing skin and eye pathology in human onchocerciasis. The filariae habour abundant intracellular Wolbachia bacteria, now recognised as obligatory symbionts, and therefore emerging as a novel target for chemotherapy. Recent research demonstrates that both th...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审

    doi:10.1016/j.micinf.2003.11.003

    authors: Brattig NW

    更新日期:2004-01-01 00:00:00

  • Pathogenic conversion of coagulase-negative staphylococci.

    abstract::Humans and animals are colonized by members of the genus Staphylococcus, however only some of these species evolved to cause invasive disease. The genetic basis for conversion of commensal staphylococci into pathogens is not known. We hypothesized that Staphylococcus aureus genes for coagulation and agglutination in v...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2016.12.002

    authors: Yu W,Kim HK,Rauch S,Schneewind O,Missiakas D

    更新日期:2017-02-01 00:00:00

  • The incidence of Streptococcus pneumoniae otitis media is affected by the polymicrobial environment particularly Moraxella catarrhalis in a mouse nasal colonisation model.

    abstract::Otitis media (OM) is a highly prevalent paediatric disease with both bacterial and viral triggers of infection. This study has investigated how combinations of bacteria associated with nasal colonisation and the occurrence and absence of viral infection (Sendai virus) induce OM in a mouse nasal colonisation model. The...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2009.03.001

    authors: Krishnamurthy A,McGrath J,Cripps AW,Kyd JM

    更新日期:2009-04-01 00:00:00

  • Assessment of cell-surface exposure and vaccinogenic potentials of Treponema pallidum candidate outer membrane proteins.

    abstract::Syphilis, a sexually transmitted infection caused by the spirochetal bacterium Treponema pallidum, remains a global public health problem. T. pallidum is believed to be an extracellular pathogen and, as such, the identification of T. pallidum outer membrane proteins that could serve as targets for opsonic or bacterici...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2007.05.018

    authors: Tomson FL,Conley PG,Norgard MV,Hagman KE

    更新日期:2007-09-01 00:00:00

  • Detection of interferon gamma-secreting CD8+ T lymphocytes in humans specific for three PE/PPE proteins of Mycobacterium tuberculosis.

    abstract::The PE and PPE family of proteins of Mycobacterium tuberculosis have been hypothesized to play important roles in the biology of the organism and some proteins have been shown to be involved in eliciting T-cell responses. Earlier, we had identified putative HLA class I binding epitopes of the PE and PPE proteins of My...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2008.04.017

    authors: Chaitra MG,Shaila MS,Nayak R

    更新日期:2008-07-01 00:00:00

  • Antibiotic resistance and virulence properties of Pseudomonas aeruginosa strains from mechanically ventilated patients with pneumonia in intensive care units: comparison with imipenem-resistant extra-respiratory tract isolates from uninfected patients.

    abstract::We investigated the epidemiology of antibiotic resistance and virulence properties among Pseudomonas aeruginosa clinical isolates collected in 1999 from patients hospitalized in the intensive care units of the centre hospitalier d'Orléans, in France. We compared the totality of the strains from mechanically ventilated...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/s1286-4579(02)01579-4

    authors: Di Martino P,Gagnière H,Berry H,Bret L

    更新日期:2002-05-01 00:00:00

  • Epithelial entry rather than the ensuing systemic immune response determines the pathogenicity of two Salmonella enterica serovar Typhimurium strains in a mouse model.

    abstract::Most studies of Salmonella enterica serovar Typhimurium infection focus only on the pathogenicity of one strain. We investigated whether differences in pathogenicity of two wild-type S. Typhimurium strains; DT120 and SL1344, were related to gut invasion or the resulting immune response. Oral administration of a ten-fo...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2013.08.004

    authors: Brandt R,Petersen A,Brix S,Licht TR,Frøkiær H

    更新日期:2013-11-01 00:00:00

  • Translocon-independent intracellular replication by Pseudomonas aeruginosa requires the ADP-ribosylation domain of ExoS.

    abstract::Pseudomonas aeruginosa, a significant cause of human morbidity and mortality, uses a type 3 secretion system (T3SS) to inject effector toxins into host cells. We previously reported that P. aeruginosa uses ADP-ribosyltransferase (ADPr) activity of the T3SS effector ExoS for intracellular replication. T3SS translocon (...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2012.08.007

    authors: Hritonenko V,Evans DJ,Fleiszig SM

    更新日期:2012-12-01 00:00:00

  • Replication potentials of vif variant viruses generated from monkey cell-tropic HIV-1 derivative clones NL-DT5/NL-DT5R.

    abstract::To obtain monkey-tropic viruses that are more closely related to HIV-1 than the original NL-DT5/NL-DT5R clones, we constructed six vif-chimeric and two site-specific vif-mutant viruses, and examined their growth ability. Different from NL-DT5/NL-DT5R, these viruses did not grow in monkey cells. We monitored the capabi...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2008.06.007

    authors: Hatcho K,Kamada K,Yamashita T,Adachi A,Nomaguchi M

    更新日期:2008-08-01 00:00:00

  • Dental screening of medical patients for oral infections and inflammation: consideration of risk and benefit.

    abstract::The primary purpose of preoperative dental screening of medical patients is to detect acute or chronic oral conditions that may require management prior to planned medical interventions. The aim of this communication is to discuss the background of preoperative dental screening and the link between dental pathologies ...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审

    doi:10.1016/j.micinf.2016.10.002

    authors: Maret D,Peters OA,Vigarios E,Epstein JB,van der Sluis L

    更新日期:2017-02-01 00:00:00

  • Regulation between survival, persistence, and elimination of intracellular mycobacteria: a nested equilibrium of delicate balances.

    abstract::This review elaborates on recent insights gained on the dynamic aspects of interactions between pathogen and the host intracellular machinery in tuberculosis infection. In addition we will also discuss the utility of adopting a systems biology approach, both for a better understanding of TB biology, and for the develo...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审

    doi:10.1016/j.micinf.2010.10.009

    authors: Kumar D,Rao KV

    更新日期:2011-02-01 00:00:00

  • Respiratory fungal allergy.

    abstract::Fungal allergy including allergic rhinitis, conjunctivitis, bronchial asthma, and allergic bronchopulmonary mycoses results from exposure to spores. In this review we have dealt with the common allergenic fungi and allergens, immunopathogenesis, diagnostic assays, and the possible control of allergy in the future base...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审

    doi:10.1016/s1286-4579(00)01264-8

    authors: Kurup VP,Shen HD,Banerjee B

    更新日期:2000-07-01 00:00:00

  • Dynamics of Ly49 expressing cytotoxic lymphocyte subsets in response to virus infection.

    abstract::Viral infections induce first a loss and then an increase in natural killer (NK) and CD8(+) T cells. NK cells expressing Ly49G2 were selectively expanded by several viruses and poly I:C. CD8(+) T cells expressing Ly49G2 were selectively expanded by poly I:C and participated in the antigen-specific response to lymphocy...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审

    doi:10.1016/s1286-4579(02)00031-x

    authors: Peacock CD,Xu W,Stepp SE,Welsh RM

    更新日期:2002-12-01 00:00:00

  • Function and distribution of EspG2, a type III secretion system effector of enteropathogenic Escherichia coli.

    abstract::The enteropathogenic Escherichia coli (EPEC) effector protein EspG, like the Shigella effector VirA, functions through disruption of the host cell microtubule network. Reports have differed as to whether the EspG homologue, EspG2, is also responsible for microtubule disruption. In this study we show that following tra...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2006.04.004

    authors: Smollett K,Shaw RK,Garmendia J,Knutton S,Frankel G

    更新日期:2006-07-01 00:00:00

  • A murine intraperitoneal infection model reveals that host resistance to Campylobacter jejuni is Nramp1 dependent.

    abstract::We tested the hypothesis that host resistance to Campylobacter jejuni is Nramp1 dependent. Following intraperitoneal (IP) inoculation of Nramp1+/+ and isogenic Nramp1-deficient (Nramp1-/-) mice C. jejuni primarily associated with mac1-positive cells in liver tissue. A significant reduction of C. jejuni was observed in...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2008.05.001

    authors: Champion OL,Valdez Y,Thorson L,Guttman JA,Menendez A,Gaynor EC,Finlay BB

    更新日期:2008-07-01 00:00:00

  • Peptides from Paracoccidioides brasiliensis GP43 inhibit macrophage functions and inflammatory response.

    abstract::Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis (Pb), a thermal dimorphic fungus. Its major antigen is a 43-kDa glycoprotein. Gp43 embodies different functions: it participates in evasion mechanisms during the installation of primary infection, stimulates granul...

    journal_title:Microbes and infection

    pub_type: 杂志文章

    doi:10.1016/j.micinf.2008.10.011

    authors: Konno AY,Maricato JT,Konno FT,Mariano M,Lopes JD

    更新日期:2009-01-01 00:00:00

  • Human host genetic factors in mycobacterial and Salmonella infection: lessons from single gene disorders in IL-12/IL-23-dependent signaling that affect innate and adaptive immunity.

    abstract::Interleukin (IL)-12/IL-23 signal transduction-deficient individuals with genetic defects in IL12RB1 or IL12B often suffer from unusual mycobacterial and Salmonella infections. Here we discuss recent questions that have arisen from clinical observations that cast doubt on the necessity of IL-12/IL-23 signaling in contr...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审

    doi:10.1016/j.micinf.2005.10.032

    authors: van de Vosse E,Ottenhoff TH

    更新日期:2006-04-01 00:00:00

  • Pathogenicity of Erysipelothrix rhusiopathiae: virulence factors and protective immunity.

    abstract::Erysipelothrix rhusiopathiae is the causative agent of erysipelas in animals and erysipeloid in humans. In the absence of specific antibodies, the organism evades phagocytosis by phagocytic cells, but even if phagocytized, it is able to replicate intracellulary in these cells. In this review, recent advances in our un...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审

    doi:10.1016/s1286-4579(00)00397-x

    authors: Shimoji Y

    更新日期:2000-07-01 00:00:00