Abstract：
:Tonsilloliths are a potential cause of oral malodor. In this study, microbial profiles and composition of tonsilloliths were determined using culture-independent molecular methods and scanning electron microscopy. 16S ribosomal RNA bacterial genes (16S rDNAs) isolated from tonsilloliths of 6 individuals were amplified by PCR and cloned into Escherichia coli. Partial 16S rDNA sequences of approximately 600 bases of cloned inserts were used to determine species identity by comparison with sequences of known species. Characteristics of bacteria on the surface and inside the tonsillolith were analyzed using scanning electron microscopy. Anaerobic bacteria detected in tonsilloliths belonged to the genera Eubacterium, Fusobacterium, Megasphaera, Porphyromonas, Prevotella, Selenomonas and Tannerella, all of which appear to be associated with production of volatile sulfur compounds. Electron microscopy revealed cocci and rods on the surface and rods predominating inside the tonsilloliths. These results support the tonsillolith as an origin of oral malodor.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Tsuneishi M,Yamamoto T,Kokeguchi S,Tamaki N,Fukui K,Watanabe Tdoi
10.1016/j.micinf.2006.04.023subject
Has Abstractpub_date
2006-08-01 00:00:00pages
2384-9issue
9-10eissn
1286-4579issn
1769-714Xpii
S1286-4579(06)00228-0journal_volume
8pub_type
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