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Lipid droplets affect elimination of Porphyromonas gingivalis in HepG2 cells by altering the autophagy-lysosome system.

Abstract：

:Recent studies have shown that infection with Porphyromonas gingivalis, a major periodontal pathogen, hastens the progression of non-alcoholic fatty liver disease (NAFLD). However, the intracellular fate of P. gingivalis in hepatocytes remains unknown. Here, using oleic-acid-induced HepG2 cells as an in vitro model for NAFLD, we found that lipid droplets increased the existence of P. gingivalis in the cells at an early phase of infection. Confocal microscopic analysis revealed that lipid droplets affected the formation of autolysosomes in infected cells. Thus, lipid droplets affect the elimination of P. gingivalis in HepG2 cells by altering the autophagy-lysosome system.

journal_name

Microbes Infect

journal_title

Microbes and infection

authors

Zaitsu Y,Iwatake M,Sato K,Tsukuba T

doi

10.1016/j.micinf.2016.05.004

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

565-71

issue

9

eissn

1286-4579

issn

1769-714X

pii

S1286-4579(16)30065-X

journal_volume

18

pub_type

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