Requirements for Th1-dependent immunity against infection with Leishmania major.

abstract：:We investigated the thymic and peripheral T-lymphocyte subsets in BALB/c mice undergoing acute or chronic Trypanosoma cruzi infection, in terms of expression of particular Vbeta rearrangements of the T-cell receptor. We first confirmed the severe depletion of CD4(+)CD8(+) thymocytes following acute T. cruzi infection....

journal_title：Microbes and infection

authors： Mendes-da-Cruz DA,de Meis J,Cotta-de-Almeida V,Savino W

更新日期：2003-08-01 00:00:00

abstract：:While the Vif protein of human immunodeficiency virus type 1 (HIV-1) is essential for viral replication in non-permissive cells, it is rapidly degraded intracellularly. We have previously suggested that the rapid turn-over of Vif is biologically meaningful to prevent detrimental effects of this protein at high express...

journal_title：Microbes and infection

authors： Fujita M,Akari H,Sakurai A,Yoshida A,Chiba T,Tanaka K,Strebel K,Adachi A

更新日期：2004-07-01 00:00:00

abstract：:Comparative genomics and microarrays reveal that the genomes of different Salmonella enterica serovars are distinguished from each other by the presence or absence of hundreds of genes. The distribution of these variable genome regions is often not clonal. Therefore, lateral gene transfer (LGT) plays an important role...

journal_title：Microbes and infection

authors： Porwollik S,McClelland M

更新日期：2003-09-01 00:00:00

abstract：:Intensive care unit (ICU)-acquired lower respiratory tract infections include acute tracheobronchitis and hospital-acquired and ventilator-associated pneumonia (VAP). Nosocomial pneumonia is the second most common hospital-acquired infection and the leading cause of death in hospital-acquired infections. The mortality...

journal_title：Microbes and infection

authors： Cavalcanti M,Valencia M,Torres A

更新日期：2005-02-01 00:00:00

abstract：:Reduction of transmission is important for effective malaria control. Standard microscopic detection grossly underestimates the human transmission reservoir. Malaria transmission intensity is defined by local and focal conditions. Transmission-blocking vaccines may be effective by directly targeting identified hot spo...

journal_title：Microbes and infection

authors： Sauerwein RW

更新日期：2007-05-01 00:00:00

abstract：:Evaluation of vector control is crucial for improving malaria containment and, according to World Health Organization, new complementary indicators would be very valuable. In this study the IgG response to the Anopheles-specific cE5 salivary protein was tested as a tool to evaluate the efficacy of insecticide-treated ...

journal_title：Microbes and infection

authors： Marie A,Ronca R,Poinsignon A,Lombardo F,Drame PM,Cornelie S,Besnard P,Le Mire J,Fiorentino G,Fortes F,Carnevale P,Remoue F,Arcà B

更新日期：2015-06-01 00:00:00

abstract：:The Mycobacterium abscessus complex can cause fatal pulmonary disease, especially in cystic fibrosis patients. Diagnosing M. abscessus complex pulmonary disease is challenging. Immunologic assays specific for M. abscessus are not available. In this study seven clinical M. abscessus complex strains and the M. abscessus...

journal_title：Microbes and infection

authors： Steindor M,Nkwouano V,Stefanski A,Stuehler K,Ioerger TR,Bogumil D,Jacobsen M,Mackenzie CR,Kalscheuer R

更新日期：2019-01-01 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) is a member of the Aphthovirus genus in the Picornaviridae family. Seven distinct serotypes, each including a wide range of variants, have been defined. FMD, affects wild and domesticated ruminants and pigs, is difficult to control and is the major constraint to international trade ...

journal_title：Microbes and infection

authors： Alexandersen S,Zhang Z,Donaldson AI

更新日期：2002-08-01 00:00:00

abstract：:Moraxella catarrhalis has again been recognized as a significant pathogen. The past decade has witnessed an increased amount of research and understanding of the pathogenesis of the organism. This review will summarize the research pertaining to the epidemiology and components of pathogenesis in M. catarrhalis. ...

journal_title：Microbes and infection

authors： Karalus R,Campagnari A

更新日期：2000-04-01 00:00:00

abstract：:The Gram-negative bacterium Burkholderia cepacia has recently emerged as an important opportunistic pathogen in humans. This review focuses on the cellular aspects of B. cepacia infection and the dynamics of the B. cepacia-host cell interaction, including recent advances in our understanding of the ability of B. cepac...

journal_title：Microbes and infection

authors： Mohr CD,Tomich M,Herfst CA

更新日期：2001-04-01 00:00:00

abstract：:Campylobacter jejuni is one of the most common causes of bacterial gastroenteritis and chronic sequelae, such as reactive arthritis and Guillain-Barré syndrome (GBS), are known to follow uncomplicated infections. While little is known about reactive arthritis following Campylobacter infection, our knowledge on the pat...

journal_title：Microbes and infection

authors： Nachamkin I

更新日期：2002-04-01 00:00:00

abstract：:Pseudomonas aeruginosa, a significant cause of human morbidity and mortality, uses a type 3 secretion system (T3SS) to inject effector toxins into host cells. We previously reported that P. aeruginosa uses ADP-ribosyltransferase (ADPr) activity of the T3SS effector ExoS for intracellular replication. T3SS translocon (...

journal_title：Microbes and infection

authors： Hritonenko V,Evans DJ,Fleiszig SM

更新日期：2012-12-01 00:00:00

abstract：:To investigate the association of viral infections with chronic fatigue syndrome (CFS), we assayed 2', 5'-oligoadenylate synthetase (2-5AS) activities in peripheral blood mononuclear cells from CFS patients in Japan. These patients were diagnosed in two hospitals, H1 and H2, located in different areas of the country. ...

journal_title：Microbes and infection

authors： Ikuta K,Yamada T,Shimomura T,Kuratsune H,Kawahara R,Ikawa S,Ohnishi E,Sokawa Y,Fukushi H,Hirai K,Watanabe Y,Kurata T,Kitani T,Sairenji T

更新日期：2003-10-01 00:00:00

abstract：:Because of its severe side effects and variable efficacy, the current treatment for Chagas disease is unsatisfactory. Natural compounds are good alternative chemotherapeutic agents for the treatment of this infection. Recently, our group reported the antiproliferative activity and morphological alterations in epimasti...

journal_title：Microbes and infection

authors： Pelizzaro-Rocha KJ,Veiga-Santos P,Lazarin-Bidóia D,Ueda-Nakamura T,Dias Filho BP,Ximenes VF,Silva SO,Nakamura CV

更新日期：2011-11-01 00:00:00

abstract：:Campylobacter jejuni and Campylobacter coli together represent the leading bacterial cause of human enteritis. However, the pathogenesis of this disease is poorly understood. Infection results in the formation of crypt abscesses resulting from the migration of neutrophils across the intestinal epithelium and into the ...

journal_title：Microbes and infection

authors： Murphy H,Cogan T,Humphrey T

更新日期：2011-01-01 00:00:00

abstract：:Interleukin (IL)-12/IL-23 signal transduction-deficient individuals with genetic defects in IL12RB1 or IL12B often suffer from unusual mycobacterial and Salmonella infections. Here we discuss recent questions that have arisen from clinical observations that cast doubt on the necessity of IL-12/IL-23 signaling in contr...

journal_title：Microbes and infection

authors： van de Vosse E,Ottenhoff TH

更新日期：2006-04-01 00:00:00

abstract：:Zika virus (ZIKV) greatly impacted the international scientific and public health communities in the last two years due to its association with microcephaly and other neonatal alterations. This review will discuss lessons learned from viral pathogenesis, epidemiology and clinical findings observed during the ZIKV outb...

journal_title：Microbes and infection

authors： Proenca-Modena JL,Milanez GP,Costa ML,Judice CC,Maranhão Costa FT

更新日期：2018-12-01 00:00:00

abstract：:Long-term protection against Toxoplasma gondii is dependent on robust CD8(+) T cell immunity. In the absence of this response, the host is unable to maintain chronicity, which results in recrudescence of infection and possible death. Factors needed for the persistence of protective CD8(+) T cells against the parasite ...

journal_title：Microbes and infection

authors： Bhadra R,Khan IA

更新日期：2012-11-01 00:00:00

abstract：:Parasites of the genus Schistosoma are organisms capable of living for decades within the definitive host. They interfere with the immune response by interacting with host's receptors. In this review, we discuss from the first reports to the most recent discoveries regarding the ability of Schistosoma antigens in trig...

journal_title：Microbes and infection

authors： Sanches RCO,Souza C,Oliveira SC

更新日期：2020-01-01 00:00:00

abstract：:The early interferon-gamma (IFN-gamma) response after Salmonella infection was compared in resistant and susceptible congenic mice strains differing by the allele of Nramp1. IFN-gamma gene expression in vivo was studied by quantitative reverse transcription-PCR performed from the spleen of mice challenged by Salmonell...

journal_title：Microbes and infection

authors： Lalmanach AC,Montagne A,Menanteau P,Lantier F

更新日期：2001-07-01 00:00:00

abstract：:Anti-retroviral therapy is useful to treat human immunodeficiency virus type 1 (HIV-1)-infected individuals, but has some major problems, such as the generation of multidrug-resistant viruses. To develop a novel supplemental or alternative therapeutic for CCR5-tropic (R5) HIV-1 infection, we generated a recombinant ve...

journal_title：Microbes and infection

authors： Okuma K,Fukagawa K,Kohma T,Takahama Y,Hamaguchi Y,Ito M,Tanaka Y,Buonocore L,Rose JK,Hamaguchi I

更新日期：2017-01-01 00:00:00

abstract：:Genomics is accelerating the progress in data generation and interpretation in the global analyses of components of cells, including the spectrum of lipids, RNA, metabolites, proteins, mutational phenotypes or DNA methylation sites. Integration of the knowledge generated by these diverse strategies is predicted to hav...

journal_title：Microbes and infection

authors： Boshoff HI,Manjunatha UH

更新日期：2006-05-01 00:00:00

abstract：:Francisella tularensis causes the zoonosis tularemia in humans, and inhaled F. tularensis ssp. novicida induces lethal murine tularemia. Transcription of virulence factors in F. novicida is regulated by macrophage growth locus A (mglA), a global regulator required for bacterial replication in macrophages in vitro. We ...

journal_title：Microbes and infection

authors： West TE,Pelletier MR,Majure MC,Lembo A,Hajjar AM,Skerrett SJ

更新日期：2008-06-01 00:00:00

abstract：:This article explores one of a citation classics in medical literature-Koch's postulates. It analyses their creation in the nineteenth century and their popularity in the twentieth century. As a genre of historiography, references to the postulates are anecdotes. In referring to a historical event that never happened,...

journal_title：Microbes and infection

authors： Gradmann C

更新日期：2014-11-01 00:00:00

abstract：:The bacterium Haemophilus ducreyi causes the sexually transmitted disease chancroid, which is characterized by the appearance of mucocutaneous, persistent ulcers on the external genitals. To identify carbohydrate receptors that mediate the attachment of this pathogen to host cells, we investigated the binding of 35S-m...

journal_title：Microbes and infection

authors： Pantzar M,Teneberg S,Lagergård T

更新日期：2006-08-01 00:00:00

abstract：:Cryptosporidium parvum is an intracellular protozoan parasite that causes severe infection in humans and animals. The great difficulties in treating people and animals suffering from cryptosporidiosis have prompted the development of in vitro experimental models. The aim of this study was to demonstrate that C. parvum...

journal_title：Microbes and infection

authors： Lacharme L,Villar V,Rojo-Vazquez FA,Suárez S

更新日期：2004-05-01 00:00:00

abstract：:Denaturing high-performance liquid chromatography (DHPLC) is a relatively new technique, which utilizes heteroduplex formation between wild-type and mutated DNA strands to identify point mutations. Heteroduplex molecules are separated from homoduplex molecules by ion-pair, reverse-phase liquid chromatography on a spec...

journal_title：Microbes and infection

authors： Shi R,Otomo K,Yamada H,Tatsumi T,Sugawara I

更新日期：2006-01-01 00:00:00

abstract：:The chemokine receptor CCR6 is expressed on naïve B cells, dendritic cell and T-cell subpopulations and is involved in cell navigation during organogenesis and recruitment in response to inflammatory stimuli. Gene-deficient C57BL/6 CCR6(-/-) mice infected with the protozoan parasite Leishmania (L.) major were able to ...

journal_title：Microbes and infection

authors： Lechner A,Ritter U,Varona R,Marquez G,Bogdan C,Körner H

更新日期：2007-03-01 00:00:00

abstract：:Staphylococcus aureus is an important cause of skin infections. We recently described an outbreak of recurrent furunculosis involving methicillin-resistant S. aureus among mentally retarded adults. We sought to determine the role of impaired neutrophil functions in its pathogenesis. Blood neutrophil functions were det...

journal_title：Microbes and infection

authors： Gilad J,Borer A,Smolyakov R,Riesenberg K,Schlaeffer F,Levy R

更新日期：2006-06-01 00:00:00

abstract：:Eleven new cases of visceral leishmaniasis (VL) are reported in organ transplant patients in France. The epidemiological, clinical, biological, diagnostic and therapeutic features are reviewed, based on these cases and 46 cases reported in the literature. VL was most commonly associated with renal transplantation (77%...

journal_title：Microbes and infection

authors： Basset D,Faraut F,Marty P,Dereure J,Rosenthal E,Mary C,Pratlong F,Lachaud L,Bastien P,Dedet JP

更新日期：2005-10-01 00:00:00