Peripheral human γδ T cells control growth of both avirulent and highly virulent strains of Francisella tularensis in vitro.

abstract：:Emerging evidence identifies multiple roles for nucleoside-diphosphate-kinase in host-microbe interaction. We provide the first synopsis of utilization of this molecule by various microorganisms during colonization of host tissues. Additionally, we propose novel mechanisms this effector may participate in, which could...

journal_title：Microbes and infection

authors： Spooner R,Yilmaz Ö

更新日期：2012-03-01 00:00:00

abstract：:Our previous study has demonstrated that IL-10 may modulate both indoleamine 2,3-dioxygenase (IDO) and CD163 expression in lepromatous leprosy (LL) cells, favoring Mycobacterium leprae persistence through induction of regulatory pathways and iron storage. Here, we observed that in LL lesion cells there is an increase ...

journal_title：Microbes and infection

authors： de Mattos Barbosa MG,da Silva Prata RB,Andrade PR,Ferreira H,de Andrade Silva BJ,da Paixão de Oliveira JA,Assis TQ,de Toledo-Pinto TG,de Lima Bezerra OC,da Costa Nery JA,Rosa PS,Bozza MT,Lara FA,Moraes MO,Schmitz V,Sarno EN

更新日期：2017-11-01 00:00:00

abstract：:Salmonella, a Gram-negative facultative intracellular pathogen is capable of infecting vast array of hosts. The striking ability of Salmonella to overcome every hurdle encountered in the host proves that they are true survivors. In the host, Salmonella infects various cell types and needs to survive and replicate by c...

journal_title：Microbes and infection

authors： Lahiri A,Lahiri A,Iyer N,Das P,Chakravortty D

更新日期：2010-10-01 00:00:00

abstract：:Following infection with Toxoplasma gondii, certain strains of mice, such as BALB/c, are genetically resistant to development of toxoplasmic encephalitis (TE) and establish a latent chronic infection as do humans. Thus, these animals appear to be a suitable model to analyze the mechanism of resistance to TE. Since the...

journal_title：Microbes and infection

authors： Suzuki Y,Kang H,Parmley S,Lim S,Park D

更新日期：2000-04-01 00:00:00

abstract：:The invasin protein encoded by enteropathogenic Yersinia allows entry of bacteria into intestinal M cells by binding to integrin receptors. In cultured cells, invasin-mediated uptake requires proteins involved in endocytosis and signaling to the cell cytoskeleton. At least four different factors have been demonstrated...

journal_title：Microbes and infection

authors： Isberg RR,Hamburger Z,Dersch P

更新日期：2000-06-01 00:00:00

abstract：:The manipulation hypothesis states a parasite may alter host behaviour for its own benefit, often by enhancing its transmission rate through the food chain. This paper reviews studies on the potential impact of one parasite, Toxoplasma gondii, on host behaviour, both on rodents, where altered responses may be proposed...

journal_title：Microbes and infection

authors： Webster JP

更新日期：2001-10-01 00:00:00

abstract：:We analyzed the distribution and expression of cadherin and beta-catenin during Trypanosoma cruzi-cardiomyocyte interaction. Confocal microscopy revealed cadherin associated with beta-catenin at the cell-cell contacts. After 24h of infection, the spatial distribution and expression of both adherens junction (AJ) prote...

journal_title：Microbes and infection

authors： de Melo TG,Meirelles Mde N,Pereira MC

更新日期：2008-10-01 00:00:00

abstract：:Anti-retroviral therapy is useful to treat human immunodeficiency virus type 1 (HIV-1)-infected individuals, but has some major problems, such as the generation of multidrug-resistant viruses. To develop a novel supplemental or alternative therapeutic for CCR5-tropic (R5) HIV-1 infection, we generated a recombinant ve...

journal_title：Microbes and infection

authors： Okuma K,Fukagawa K,Kohma T,Takahama Y,Hamaguchi Y,Ito M,Tanaka Y,Buonocore L,Rose JK,Hamaguchi I

更新日期：2017-01-01 00:00:00

abstract：:Secreted phospholipase B (PLB1), which contains three enzyme activities in the one protein, is necessary for the initiation of pulmonary infection by Cryptococcus neoformans and for dissemination from the lung via the lymphatics and blood. Adhesion to lung epithelium is the first step in this process, therefore we inv...

journal_title：Microbes and infection

authors： Ganendren R,Carter E,Sorrell T,Widmer F,Wright L

更新日期：2006-04-01 00:00:00

abstract：:Grain feeding seems to promote the growth and acid resistance of Escherichia coli in fattening beef cattle, and acid-resistant E. coli are more likely to survive the human gastric stomach. When cattle were fed hay for only five days, the number and acid resistance of E. coli decreased dramatically. ...

journal_title：Microbes and infection

authors： Russell JB,Diez-Gonzalez F,Jarvis GN

更新日期：2000-01-01 00:00:00

abstract：:We previously showed the possibility that Gag A146P, which is an escape mutant from HLA-B∗57-restricted CTLs, was selected by HLA-B∗48:01-restricted Gag138-147(LI10)-specific CTLs in a Japanese cohort in which HLA-B∗57 individuals were not detected. We herein demonstrated Gag140-147(GI8) to be the optimal epitope rath...

journal_title：Microbes and infection

authors： Naruto T,Murakoshi H,Chikata T,Koyanagi M,Kawashima Y,Gatanaga H,Oka S,Takiguchi M

更新日期：2011-08-01 00:00:00

abstract：:Autoantibodies against various components of host are known to occur in leprosy. Nerve damage is the primary cause of disability associated with leprosy. The aim of this study was to detect the level of autoantibodies and lympho-proliferative response against myelin basic protein (MBP) in leprosy patients (LPs) and th...

journal_title：Microbes and infection

authors： Singh I,Yadav AR,Mohanty KK,Katoch K,Sharma P,Mishra B,Bisht D,Gupta UD,Sengupta U

更新日期：2015-04-01 00:00:00

abstract：:Lipoarabinomannans (LAMs) from mycobacteria were investigated concerning their effect on human neutrophils. Two types of LAM, the mannose-capped ManLAM from the virulent Mycobacterium tuberculosis H37Rv and the mannose-lacking AraLAM from a rapidly growing mycobacterial strain were used. Neither AraLAM nor ManLAM indu...

journal_title：Microbes and infection

authors： Fäldt J,Dahlgren C,Ridell M,Karlsson A

更新日期：2001-11-01 00:00:00

abstract：:Because of its severe side effects and variable efficacy, the current treatment for Chagas disease is unsatisfactory. Natural compounds are good alternative chemotherapeutic agents for the treatment of this infection. Recently, our group reported the antiproliferative activity and morphological alterations in epimasti...

journal_title：Microbes and infection

authors： Pelizzaro-Rocha KJ,Veiga-Santos P,Lazarin-Bidóia D,Ueda-Nakamura T,Dias Filho BP,Ximenes VF,Silva SO,Nakamura CV

更新日期：2011-11-01 00:00:00

abstract：:The intestine is inhabited by a diverse range of microorganisms, which requires the host to employ numerous barrier measures to prevent bacterial invasion. However, the intestinal microbiota additionally acts symbiotically with host cells to maintain epithelial barrier function, and perturbation to this interaction pl...

journal_title：Microbes and infection

authors： Goyal S,Tsang DKL,Maisonneuve C,Girardin SE

更新日期：2020-11-12 00:00:00

abstract：:Over the last 10 years - in Microbes and Infection - the publications dealing with protozoan parasites were mainly providing insights on the pathogenic processes leading to the local or systemic damages in the mammals, these parasitic organisms exploit/subvert as hosts. As a result, many investigators introduced the o...

journal_title：Microbes and infection

authors： Milon G

更新日期：2008-07-01 00:00:00

abstract：:Several observations suggest that inhibition of the host complement alternative pathway by Ixodes tick saliva is crucial to achieve blood feeding. We recently described two paralogous anti-complement proteins called Ixodes ricinus anti-complement (IRAC) proteins I and II co-expressed in I. ricinus salivary glands. Phy...

journal_title：Microbes and infection

authors： Schroeder H,Daix V,Gillet L,Renauld JC,Vanderplasschen A

更新日期：2007-02-01 00:00:00

abstract：:In the present study, we compared the B cell response of BALB/c and C57Bl/6 mice during Cryptococcus neoformans infection. This response was investigated using virulent serotype D forms of mating types alpha and a (MAT alpha and MAT a). C57Bl/6 mice showed massive (mainly cerebral) infection by both types, while BALB/...

journal_title：Microbes and infection

authors： Rodrigues AR,Heise N,Previato JO,Mendonça-Previato L,Peçanha LM

更新日期：2005-01-01 00:00:00

abstract：:Sheep develop clinical diseases after 3-5 years after infection with Mycobacterium avium subsp. paratuberculosis (MAP). Clinical symptoms of paratuberculosis include persistent diarrhea and weight loss due to a chronic inflammation of the small intestine. Tissue alterations in the areas of the ileo-cecal junction are ...

journal_title：Microbes and infection

authors： Rossi G,Nigro G,Tattoli I,Vincenzetti S,Mariani P,Magi GE,Renzoni G,Taccini E,Bernardini ML

更新日期：2009-05-01 00:00:00

abstract：:Surfactant protein C (SP-C) is a highly hydrophobic protein found in pulmonary surfactant. SP-C is synthesized exclusively in alveolar type II cells as a 21 kDa integral membrane precursor protein and subsequently proteolytically processed to a 3.7 kDa secretory protein. SP-C enhances the adsorption and spreading of p...

journal_title：Microbes and infection

authors： Mulugeta S,Beers MF

更新日期：2006-07-01 00:00:00

abstract：:Despite high vaccination coverage, pertussis remains an important respiratory infectious disease and the least-controlled vaccine-preventable infectious disease in children. Natural infection with Bordetella pertussis is known to induce strong and long-lasting immunity that wanes later than vaccine-mediated immunity. ...

journal_title：Microbes and infection

authors： Lim A,Ng JK,Locht C,Alonso S

更新日期：2014-01-01 00:00:00

abstract：:AIDS patients frequently exhibit neurological disorders due to the neurotoxic events that result from HIV-1 and/or opportunistic infections in the brain. This review examines recent clinical findings related to HIV-1-associated dementia, and outlines current areas of basic research that may clarify how HIV-1-associate...

journal_title：Microbes and infection

authors： Lawrence DM,Major EO

更新日期：2002-03-01 00:00:00

abstract：:Coxiella burnetii is an intracellular bacterium that causes acute and chronic Q fever. This unique pathogen has been historically challenging to study due to obstacles in genetically manipulating the organism and the inability of small animal models to fully mimic human Q fever. Here, we review the current state of C....

journal_title：Microbes and infection

authors： Dragan AL,Voth DE

更新日期：2020-04-01 00:00:00

abstract：:Two strains of mice selected according to extreme phenotypes of susceptibility and resistance to oral tolerance (TS and TR mice, respectively) were infected with 1 x 10(7) Leishmania amazonensis promastigotes and studied comparatively. TS mice developed a minor pathology while permitting parasite growth with the prese...

journal_title：Microbes and infection

authors： Tavares D,da Conceição Ribeiro R,Carlos da Silva A

更新日期：2006-04-01 00:00:00

abstract：:Attenuated Salmonella induce immunosuppressive, microbicidal and tumoricidal macrophages in mice. All three effects are mediated by activated macrophages producing nitric oxide (NO). NO is induced by the innate immune response pathway involving IL-12, NK cells and IFN-gamma in response to infection. NO has beneficial ...

journal_title：Microbes and infection

authors： Eisenstein TK

更新日期：2001-11-01 00:00:00

abstract：:The objective of this study was to determine if inflammatory tolerance and enhancement of innate immune function could be induced by the Gram-positive cell wall component peptidoglycan (PGN). Male mice (C57BL6/J or C3H/HeJ, 8-12 weeks of age) were given intraperitoneal injections of 1mg PGN on 2 consecutive days. The ...

journal_title：Microbes and infection

authors： Murphey ED,Sherwood ER

更新日期：2008-10-01 00:00:00

abstract：:Vibrio vulnificus is capable of causing severe and often fatal infections in susceptible individuals. It causes two distinct disease syndromes, a primary septicemia and necrotizing wound infections. This review discusses the interaction of environmental conditions, host factors, and bacterial virulence determinants th...

journal_title：Microbes and infection

authors： Strom MS,Paranjpye RN

更新日期：2000-02-01 00:00:00

abstract：:Lactobacillus colonisation was examined in 112 Swedish infants. Faecal samples obtained at 1, 2, 4 and 8 weeks and at 6, 12 and 18 months of age were cultivated quantitatively on Rogosa agar. Lactobacilli were speciated by PCR and typed to the strain level by randomly amplified polymorphic DNA (RAPD). Lactobacilli rea...

journal_title：Microbes and infection

authors： Ahrné S,Lönnermark E,Wold AE,Aberg N,Hesselmar B,Saalman R,Strannegård IL,Molin G,Adlerberth I

更新日期：2005-08-01 00:00:00

abstract：:We investigated the thymic and peripheral T-lymphocyte subsets in BALB/c mice undergoing acute or chronic Trypanosoma cruzi infection, in terms of expression of particular Vbeta rearrangements of the T-cell receptor. We first confirmed the severe depletion of CD4(+)CD8(+) thymocytes following acute T. cruzi infection....

journal_title：Microbes and infection

authors： Mendes-da-Cruz DA,de Meis J,Cotta-de-Almeida V,Savino W

更新日期：2003-08-01 00:00:00

abstract：:DNA microarray was used as a tool to define the heat- and cold-shock stimulons in Yersinia pestis. Heat shock dramatically enhanced the transcription of genes encoding major heat-shock proteins (MHSPs) that are important for cell survival against the heat. Many other genes were also greatly up-regulated, but their rol...

journal_title：Microbes and infection

authors： Han Y,Zhou D,Pang X,Zhang L,Song Y,Tong Z,Bao J,Dai E,Wang J,Guo Z,Zhai J,Du Z,Wang X,Wang J,Huang P,Yang R

更新日期：2005-03-01 00:00:00