Abstract:
:Surfactant protein C (SP-C) is a highly hydrophobic protein found in pulmonary surfactant. SP-C is synthesized exclusively in alveolar type II cells as a 21 kDa integral membrane precursor protein and subsequently proteolytically processed to a 3.7 kDa secretory protein. SP-C enhances the adsorption and spreading of phospholipids at the air-liquid interface thereby promoting the surface tension-lowering properties of surfactant. The importance of SP-C in normal lung function is underscored by the recent findings of inflammatory lung diseases associated both with absence of alveolar SP-C and with cellular expression of mutant SP-C isoforms. This review examines our current understanding of the role of SP-C in maintaining alveolar epithelial homeostasis and the potential role of abnormal SP-C expression in the development of lung diseases with particular emphasis on microbial pulmonary infection and inflammation.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Mulugeta S,Beers MFdoi
10.1016/j.micinf.2006.04.009subject
Has Abstractpub_date
2006-07-01 00:00:00pages
2317-23issue
8eissn
1286-4579issn
1769-714Xpii
S1286-4579(06)00172-9journal_volume
8pub_type
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journal_title:Microbes and infection
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journal_title:Microbes and infection
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journal_title:Microbes and infection
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journal_title:Microbes and infection
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abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
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journal_title:Microbes and infection
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