Abstract：
:Patients with paracoccidioidomycosis (PCM) present marked involvement of the lungs during the course of the mycosis. The purpose of this work was to obtain bronchoalveolar lavage (BAL) fluid from these patients to study the cytopathology, TNF levels and the oxidative and fungicidal response of alveolar macrophages (AMs) to in vitro incubation with recombinant IFN-gamma. To compare the lung and blood compartments, these determinations were also made in plasma and blood monocytes (BMs) obtained from the same patients. The cytopathology of BAL fluid revealed a predominance of macrophages, but with the presence of neutrophil exudation, and rare lymphocytes and epithelioid and giant cells. Comparison of the oxidative status and fungicidal activity of AMs and circulating BMs demonstrated that both cell types are highly activated for these two functions when compared to control cells. However, TNF levels were higher in BAL fluid than in plasma. The possible mechanisms involved in the hyperresponsiveness of cells from PCM patients are discussed.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Calvi SA,Soares AM,Peraçoli MT,Franco M,Ruiz RL Jr,Marcondes-Machado J,Fecchio D,Mattos MC,Mendes RPdoi
10.1016/j.micinf.2003.05.001subject
Has Abstractpub_date
2003-12-01 00:00:00pages
1373-9issue
15eissn
1286-4579issn
1769-714Xpii
S1286457903002600journal_volume
5pub_type
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