Abstract:
:Research into intracellular sensing of microbial products is an up and coming field in innate immunity. Nod1 and Nod2 are members of the rapidly expanding family of NACHT domain-containing proteins involved in intracellular recognition of bacterial products. Nods proteins are involved in the cytosolic detection of peptidoglycan motifs of bacteria, recognized through the LRR domain. The role of the NACHT-LRR system of detection in innate immune responses is highlighted at the mucosal barrier, where most of the membranous Toll like receptors (TLRs) are not expressed, or with pathogens that have devised ways to escape TLR sensing. For a given pathogen, the sum of the pathways induced by the recognition of the different "pathogen associated molecular patterns" (PAMPs) by the different pattern recognition receptors (PRRs) trigger and shape the subsequent innate and adaptive immune responses. Knowledge gathered during the last decade on PRR and their agonists, and recent studies on bacterial infections provide new insights into the immune response and the pathogenesis of human infectious diseases.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Bourhis LL,Werts Cdoi
10.1016/j.micinf.2007.01.014subject
Has Abstractpub_date
2007-04-01 00:00:00pages
629-36issue
5eissn
1286-4579issn
1769-714Xpii
S1286-4579(07)00038-Xjournal_volume
9pub_type
杂志文章,评审abstract::Osteoarticular brucellosis is the most frequent complication of active disease. A large amount of cells in bone are osteocytes. Since bone remodeling process is regulated by hormones we sought to study the effect of cortisol and DHEA in Brucella abortus-infected osteocytes. Cortisol treatment inhibited the expression ...
journal_title:Microbes and infection
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更新日期:2019-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/s1286-4579(00)00318-x
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pub_type: 杂志文章
doi:10.1016/s1286-4579(03)00046-7
更新日期:2003-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(00)00270-7
更新日期:2000-02-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.02.020
更新日期:2006-06-01 00:00:00
abstract::Protective immunity against cutaneous leishmaniasis is dependent on the induction of Th1/Tc1 immune responses resulting in efficient parasite elimination. In this review, the mechanisms leading to protection are discussed with special focus on the role of Leishmania major-infected dendritic cells (DC) in induction of ...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2004.05.024
更新日期:2004-10-01 00:00:00
abstract::Hepatitis C virus (HCV) causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma in addition to acute hepatitis. The HCV genome encodes two envelope glycoproteins, E1 and E2. To investigate the role of E1 and E2 in HCV infection, we used a recombinant vesicular stomatitis virus (VSV), VSVdeltaG*, harbori...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2004.09.006
更新日期:2005-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2015.09.025
更新日期:2016-02-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2013.10.013
更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s1286-4579(02)01590-3
更新日期:2002-06-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2015.02.004
更新日期:2015-06-01 00:00:00
abstract::The strategies that allow Brucella abortus to persist for years inside macrophages subverting host immune responses are not completely understood. Immunity against this bacterium relies on the capacity of IFN-γ to activate macrophages, endowing them with the ability to destroy intracellular bacteria. We report here th...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2010.10.020
更新日期:2011-03-01 00:00:00
abstract::CD4(+)CD25(+) T cells regulate the activity of autoreactive T cells. Depletion of these cells results in the development of a wide-spectrum of organ-specific autoimmune diseases. In vitro model systems have been developed to study the function of these potent suppressor cells. Following their activation via their T-ce...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(01)01453-8
更新日期:2001-09-01 00:00:00
abstract::To increase knowledge of the pathogenic potential of the Burkholderia cepacia complex (BCC), we investigated the effects of reference strains of the nine BCC species on human bronchial epithelial cells in vitro. B. multivorans exhibited the highest rates of adherence to and internalization by host cells. Two out of th...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2007.10.002
更新日期:2008-01-01 00:00:00
abstract::In this report, we examined the genetic diversity of HIV-1 strains circulating in the city of Beira, the second largest metropolitan area in Mozambique. A total of 131 blood samples, collected between August and October 2003 from antiretroviral-naïve individuals, were characterized with a combined approach consisting ...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.05.005
更新日期:2006-08-01 00:00:00
abstract::Toll-like receptors recognize specific patterns of microbial components and regulate the activation of both innate and adaptive immunity. TLR4 recognizes lipopolysaccharide (LPS) in monocytes/macrophages with the help of other molecules like CD14 and MD-2, which indicates that the functional LPS receptor forms a large...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2004.05.010
更新日期:2004-09-01 00:00:00
abstract::The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue i...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2012.04.011
更新日期:2012-08-01 00:00:00
abstract::Francisella tularensis causes the zoonosis tularemia in humans, and inhaled F. tularensis ssp. novicida induces lethal murine tularemia. Transcription of virulence factors in F. novicida is regulated by macrophage growth locus A (mglA), a global regulator required for bacterial replication in macrophages in vitro. We ...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2008.04.008
更新日期:2008-06-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(03)00071-6
更新日期:2003-05-01 00:00:00
abstract::Many viruses regulate a crucial point in the apoptotic pathway by expressing viral Bcl-2 homologues, which have become useful tools to investigate the mechanisms behind the control of the mitochondrial checkpoint of apoptosis. Concurrently, a number of viral inhibitors of innate immune signalling have been instrumenta...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2009.08.012
更新日期:2009-11-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.10.020
更新日期:2006-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2013.02.002
更新日期:2013-06-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(00)00329-4
更新日期:2000-04-01 00:00:00
abstract::Exhaustive information on the Epstein-Barr virus, a member of the herpes family, is described at the International Herpes Management Forum web-site. Cervical cancer associations, AIDS treatment projects, and the Los Alamos National Laboratories provide useful information on papillomavirus infections, as well as hyperl...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/s1286-4579(00)01308-3
更新日期:2000-10-01 00:00:00
abstract::African trypanosomes (prototype: Trypanosoma brucei) are flagellated protozoan parasites that infect a wide variety of mammals, causing nagana in cattle and sleeping sickness in humans. These organisms can cause prolonged chronic infections due to their ability to successively expose different antigenic variants of th...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.10.002
更新日期:2006-03-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2009.03.001
更新日期:2009-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(01)01492-7
更新日期:2001-11-01 00:00:00
abstract::Multilocus enzyme electrophoresis (MLEE) is the gold standard for taxonomy and strain typing of Leishmania, but has some limitations. An alternative reliable and fast genotyping method for addressing population genetic and key epidemiological questions, is multilocus microsatellite typing (MLMT). MLMT using 15 markers...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.12.009
更新日期:2007-03-01 00:00:00
abstract::Currently, there is no specific antiviral therapy for HPV infection. We conducted a randomized open-label clinical trial of JB01-BD, an anti-HPV biological dressing from Shanxi Jinbo Pharmaceutical Co., Ltd., China, for treatment of HPV infection. Seventy-seven women with cervical infection by high-risk HPV were rando...
journal_title:Microbes and infection
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.micinf.2015.10.004
更新日期:2016-02-01 00:00:00
abstract::Overlapping peptides of different lengths from a certain immunodominant region can be presented by the same HLA class I molecule and elicit different T cell responses. However, how peptide-length specificity of antigen-specific CD8(+) T lymphocytes influence cross-reactivity profiles of these cells remains elusive. Th...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2013.12.005
更新日期:2014-04-01 00:00:00