Role of Nods in bacterial infection.

Abstract:

:Research into intracellular sensing of microbial products is an up and coming field in innate immunity. Nod1 and Nod2 are members of the rapidly expanding family of NACHT domain-containing proteins involved in intracellular recognition of bacterial products. Nods proteins are involved in the cytosolic detection of peptidoglycan motifs of bacteria, recognized through the LRR domain. The role of the NACHT-LRR system of detection in innate immune responses is highlighted at the mucosal barrier, where most of the membranous Toll like receptors (TLRs) are not expressed, or with pathogens that have devised ways to escape TLR sensing. For a given pathogen, the sum of the pathways induced by the recognition of the different "pathogen associated molecular patterns" (PAMPs) by the different pattern recognition receptors (PRRs) trigger and shape the subsequent innate and adaptive immune responses. Knowledge gathered during the last decade on PRR and their agonists, and recent studies on bacterial infections provide new insights into the immune response and the pathogenesis of human infectious diseases.

journal_name

Microbes Infect

journal_title

Microbes and infection

authors

Bourhis LL,Werts C

doi

10.1016/j.micinf.2007.01.014

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

629-36

issue

5

eissn

1286-4579

issn

1769-714X

pii

S1286-4579(07)00038-X

journal_volume

9

pub_type

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