Abstract:
:To obtain monkey-tropic viruses that are more closely related to HIV-1 than the original NL-DT5/NL-DT5R clones, we constructed six vif-chimeric and two site-specific vif-mutant viruses, and examined their growth ability. Different from NL-DT5/NL-DT5R, these viruses did not grow in monkey cells. We monitored the capability of the mutants to antagonize monkey APOBEC3G/F by single-cycle infectivity assays. They counteracted poorly or not at all the action of the APOBEC3G/F. Our results have indicated that the native SIVmac Vif is required to overcome the species barrier against HIV-1.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Hatcho K,Kamada K,Yamashita T,Adachi A,Nomaguchi Mdoi
10.1016/j.micinf.2008.06.007subject
Has Abstractpub_date
2008-08-01 00:00:00pages
1218-22issue
10-11eissn
1286-4579issn
1769-714Xpii
S1286-4579(08)00150-0journal_volume
10pub_type
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