Abstract：
:Campylobacter jejuni and Campylobacter coli together represent the leading bacterial cause of human enteritis. However, the pathogenesis of this disease is poorly understood. Infection results in the formation of crypt abscesses resulting from the migration of neutrophils across the intestinal epithelium and into the intestinal crypts. In this study, we model this process in vitro and show that Campylobacter infection of epithelium results in a quantifiable increase in the directed movement of neutrophils from the basolateral to apical surface of the epithelium. This process is dependent on both bacterially derived n-formyl peptides and on the host cell enzyme 12-lipoxygenase (12-LOX).
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Murphy H,Cogan T,Humphrey Tdoi
10.1016/j.micinf.2010.09.007subject
Has Abstractpub_date
2011-01-01 00:00:00pages
42-8issue
1eissn
1286-4579issn
1769-714Xpii
S1286-4579(10)00237-6journal_volume
13pub_type
杂志文章abstract：:Intensive care unit (ICU)-acquired lower respiratory tract infections include acute tracheobronchitis and hospital-acquired and ventilator-associated pneumonia (VAP). Nosocomial pneumonia is the second most common hospital-acquired infection and the leading cause of death in hospital-acquired infections. The mortality...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.12.001
更新日期：2005-02-01 00:00:00
abstract：:Intracellular replication of Cryptosporidium parvum (Apicomplexa) involves the generation of several asexual and sexual forms of the parasite. During the stage conversions, complex mechanisms lead to differential structural and functional properties of the parasite. These require a well tuned gene transcription machin...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.04.012
更新日期：2006-07-01 00:00:00
abstract：:Fungal allergy including allergic rhinitis, conjunctivitis, bronchial asthma, and allergic bronchopulmonary mycoses results from exposure to spores. In this review we have dealt with the common allergenic fungi and allergens, immunopathogenesis, diagnostic assays, and the possible control of allergy in the future base...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)01264-8
更新日期：2000-07-01 00:00:00
abstract：:To increase knowledge of the pathogenic potential of the Burkholderia cepacia complex (BCC), we investigated the effects of reference strains of the nine BCC species on human bronchial epithelial cells in vitro. B. multivorans exhibited the highest rates of adherence to and internalization by host cells. Two out of th...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.10.002
更新日期：2008-01-01 00:00:00
abstract：:Multilocus enzyme electrophoresis (MLEE) is the gold standard for taxonomy and strain typing of Leishmania, but has some limitations. An alternative reliable and fast genotyping method for addressing population genetic and key epidemiological questions, is multilocus microsatellite typing (MLMT). MLMT using 15 markers...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.12.009
更新日期：2007-03-01 00:00:00
abstract：:West Nile virus is now distributed throughout many temperate, subtropical and tropical areas: vaccines need to be developed that are affordable for developed and developing countries. Here, we constructed and evaluated a DNA vaccine expressing the premembrane and envelope proteins of West Nile virus (pcWNME). Mice imm...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.05.013
更新日期：2007-07-01 00:00:00
abstract：:We previously found that, in a mouse model of Chagas cardiomyopathy, 18% of the 9390 quantified unigenes were significantly regulated by Trypanosoma cruzi infection. However, treatment with bone marrow-derived mononuclear cells (MNCs) resulted in 84% transcriptomic recovery. We have applied new algorithms to reanalyze...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2017.11.003
更新日期：2018-03-01 00:00:00
abstract：:Macrophages respond to infection with Legionella pneumophila by the induction of inflammatory mediators, including type I Interferons (IFN-Is). To explore whether the bacterial second messenger cyclic 3'-5' diguanylate (c-diGMP) activates some of these mediators, macrophages were infected with L. pneumophila strains i...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2011.09.002
更新日期：2012-02-01 00:00:00
abstract：:Several bacterial pathogens interact with their host through protein secretion effectuated by a type VI secretion system (T6SS). Francisella tularensis is a highly pathogenic intracellular bacterium that causes the disease tularemia. Proteins encoded by the Francisella pathogenicity island (FPI), which constitute a ty...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2016.07.006
更新日期：2016-12-01 00:00:00
abstract：:Human histocompatibility leukocyte antigen (HLA)-G is an antigen-presenting molecule. This review discusses the possibility that this might not be its primary function. HLA-G indeed modulates innate immunity by interacting with immunoglobulin-like receptors and by regulating HLA-E expression and its subsequent interac...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(01)01386-7
更新日期：2001-04-01 00:00:00
abstract：:Population genetic structure and subdivision are key factors affecting the evolution of organisms. In this study, we analysed and compared the population genetic structure of the malaria parasite Plasmodium falciparum and its mosquito vector Anopheles gambiae over space and time in the Nianza Province, near Victoria L...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.12.021
更新日期：2008-03-01 00:00:00
abstract：:The type III secretion system of Salmonella enterica serovar Typhimurium can be used to target heterologous antigens directly into the cytosol of antigen-presenting cells. Our laboratory has previously reported that the single oral immunization of mice with a recombinant Salmonella strain expressing the translocated Y...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.02.007
更新日期：2005-05-01 00:00:00
abstract：:We tested the hypothesis that host resistance to Campylobacter jejuni is Nramp1 dependent. Following intraperitoneal (IP) inoculation of Nramp1+/+ and isogenic Nramp1-deficient (Nramp1-/-) mice C. jejuni primarily associated with mac1-positive cells in liver tissue. A significant reduction of C. jejuni was observed in...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.05.001
更新日期：2008-07-01 00:00:00
abstract：:Vibrio cholerae induces either non-inflammatory diarrhea or inflammatory gastroenteritis, depending on the presence of cholera toxin, a fluid secretion inducer and a modulator of host immunity. In the absence of cholera toxin, other toxins induce inflammation, resulting in gastroenteritis. Thus, multiple toxins likely...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2003.08.007
更新日期：2003-11-01 00:00:00
abstract：:We investigated the roles of the regulatory molecules glucocorticoid-induced TNF receptor family-related protein (GITR) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) in murine infection with the nematode parasite Trichinella spiralis. Expression of GITR and CTLA-4 was rapidly upregulated on cells in the mes...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.08.013
更新日期：2006-10-01 00:00:00
abstract：:Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to improve MYXV as an onco...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2010.08.012
更新日期：2010-12-01 00:00:00
abstract：:In the present study, we compared the B cell response of BALB/c and C57Bl/6 mice during Cryptococcus neoformans infection. This response was investigated using virulent serotype D forms of mating types alpha and a (MAT alpha and MAT a). C57Bl/6 mice showed massive (mainly cerebral) infection by both types, while BALB/...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.09.009
更新日期：2005-01-01 00:00:00
abstract：:Immature dendritic cells (Dcs) are characterised by high antigen uptake ability and poor T-cell stimulatory function. In contrast, mature DCs have a high stimulatory function and poor antigen uptake ability. Inflammatory stimuli induce DC maturation and migration from nonlymphoid tissues to lymphoid organs. We investi...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(99)00209-9
更新日期：1999-11-01 00:00:00
abstract：:Campylobacter jejuni is the predominant cause of antecedent infection in Guillain-Barré syndrome (GBS) or Miller Fisher syndrome (MFS). C. jejuni probably triggers GBS or MFS through molecular mimicry between bacterial sialylated lipo-oligosaccharides (LOS) and gangliosides in peripheral nerve tissue. We investigated ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.06.022
更新日期：2006-01-01 00:00:00
abstract：:DNA microarray was used as a tool to define the heat- and cold-shock stimulons in Yersinia pestis. Heat shock dramatically enhanced the transcription of genes encoding major heat-shock proteins (MHSPs) that are important for cell survival against the heat. Many other genes were also greatly up-regulated, but their rol...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.11.005
更新日期：2005-03-01 00:00:00
abstract：:Exhaustive information on the Epstein-Barr virus, a member of the herpes family, is described at the International Herpes Management Forum web-site. Cervical cancer associations, AIDS treatment projects, and the Los Alamos National Laboratories provide useful information on papillomavirus infections, as well as hyperl...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(00)01308-3
更新日期：2000-10-01 00:00:00
abstract：:Antineutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability-increasing protein (BPI) were repeatedly found in cystic fibrosis (CF) patients. We analyzed the effect of BPI-ANCA in inhibiting neutrophil-mediated killing of Pseudomonas aeruginosa. The bactericidal effect expressed as percentag...
journal_title：Microbes and infection
pub_type： 信件
doi：10.1016/s1286-4579(02)00049-7
更新日期：2003-01-01 00:00:00
abstract：:The Mycobacterium abscessus complex can cause fatal pulmonary disease, especially in cystic fibrosis patients. Diagnosing M. abscessus complex pulmonary disease is challenging. Immunologic assays specific for M. abscessus are not available. In this study seven clinical M. abscessus complex strains and the M. abscessus...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2018.10.006
更新日期：2019-01-01 00:00:00
abstract：:This study examined the impact of concurrent parasite infections (amoebiasis, filariasis, necatoriasis) and the effect of anti-parasite treatment on cytokine and chemokine responses in singly and poly-parasitized patients. Cellular reactivity and parasite-specific Th1- and Th2-type cytokine and chemokine profiles were...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.06.019
更新日期：2006-01-01 00:00:00
abstract：:This article explores one of a citation classics in medical literature-Koch's postulates. It analyses their creation in the nineteenth century and their popularity in the twentieth century. As a genre of historiography, references to the postulates are anecdotes. In referring to a historical event that never happened,...
journal_title：Microbes and infection
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.micinf.2014.08.012
更新日期：2014-11-01 00:00:00
abstract：:Protective immunity against cutaneous leishmaniasis is dependent on the induction of Th1/Tc1 immune responses resulting in efficient parasite elimination. In this review, the mechanisms leading to protection are discussed with special focus on the role of Leishmania major-infected dendritic cells (DC) in induction of ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2004.05.024
更新日期：2004-10-01 00:00:00
abstract：:Previously, we demonstrated that Valpha14+ NKT cells and IFN-gamma are important upstream components in neutrophil-mediated host defense against infection with Streptococcus pneumoniae. In the present study, we extended these findings by elucidating the role of IFN-gamma in this Valpha14+ NKT cell-promoted process. Ad...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.12.003
更新日期：2007-03-01 00:00:00
abstract：:Human immunodeficiency virus type 1 (HIV-1) mostly owes its success to its ability to evade host immune responses. Understanding viral immune escape mechanisms is a prerequisite to improve future HIV-1 vaccine design. This review focuses on the strategies that HIV-1 has evolved to evade recognition by natural killer (...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2012.05.001
更新日期：2012-09-01 00:00:00
abstract：:Secreted phospholipase B (PLB1), which contains three enzyme activities in the one protein, is necessary for the initiation of pulmonary infection by Cryptococcus neoformans and for dissemination from the lung via the lymphatics and blood. Adhesion to lung epithelium is the first step in this process, therefore we inv...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.10.018
更新日期：2006-04-01 00:00:00
abstract：:Burkholderia pseudomallei is a major cause of bacterial septicemias in many parts of the world, particularly Thailand; the known geographic range of the organism appears to be enlarging as awareness of the organism and the disease it causes--melioidosis--increases. B. pseudomallei is intrinsically resistant to most an...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(99)80007-0
更新日期：1999-02-01 00:00:00
