Abstract：
:Cell-mediated immunity to Toxoplasma gondii establishes and maintains a balanced host-pathogen relationship. Recent analyses using spontaneous and genetically engineered mouse mutants have yielded a clearer picture of factors positively and negatively regulating the host immune response and a better understanding of cytokine-inducible intracytoplasmic mechanisms that lead to intracellular pathogen suppression and demise.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Yap GS,Shaw MH,Ling Y,Sher Adoi
10.1016/j.micinf.2005.10.031subject
Has Abstractpub_date
2006-04-01 00:00:00pages
1174-8issue
4eissn
1286-4579issn
1769-714Xpii
S1286-4579(05)00455-7journal_volume
8pub_type
杂志文章,评审abstract：:Human infection with Toxoplasma gondii is generally asymptomatic in immunocompetent adults while it causes significant morbidity in congenitally infected children. Cell mediated immunity plays the main role in host resistance to T. gondii infection and a Th1 cytokine profile is necessary for protection and control of ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.10.017
更新日期：2007-02-01 00:00:00
abstract：:To investigate the association of viral infections with chronic fatigue syndrome (CFS), we assayed 2', 5'-oligoadenylate synthetase (2-5AS) activities in peripheral blood mononuclear cells from CFS patients in Japan. These patients were diagnosed in two hospitals, H1 and H2, located in different areas of the country. ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2003.07.002
更新日期：2003-10-01 00:00:00
abstract：:Infection of colonic epithelial cells by Shigella is associated with the type III secretion system, which serves as a molecular syringe to inject effectors into host cells. This system includes an extracellular needle used as a conduit for secreted proteins. Two of these proteins, IpaB and IpaD, dock at the needle tip...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2014.03.010
更新日期：2014-07-01 00:00:00
abstract：:Mucosal epithelia constitute the first barriers to be overcome by pathogens during infection. The induction of protective IgA in this location is important for the prevention of infection and can be achieved through different mucosal immunization strategies. Lactic acid bacteria have been tested in the last few years ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.10.020
更新日期：2006-04-01 00:00:00
abstract：:Pathogenic Leptospira species are the causative agents of leptospirosis, a global zoonotic infectious disease. Toxin-antitoxin (TA) modules have been confirmed as stress-response elements that induce prokaryotic and eukaryotic cell-growth arrest or death, but their role in the virulence of Leptospira has not been repo...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2014.10.010
更新日期：2015-01-01 00:00:00
abstract：:The early interferon-gamma (IFN-gamma) response after Salmonella infection was compared in resistant and susceptible congenic mice strains differing by the allele of Nramp1. IFN-gamma gene expression in vivo was studied by quantitative reverse transcription-PCR performed from the spleen of mice challenged by Salmonell...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(01)01419-8
更新日期：2001-07-01 00:00:00
abstract：:We analyzed the distribution and expression of cadherin and beta-catenin during Trypanosoma cruzi-cardiomyocyte interaction. Confocal microscopy revealed cadherin associated with beta-catenin at the cell-cell contacts. After 24h of infection, the spatial distribution and expression of both adherens junction (AJ) prote...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.07.044
更新日期：2008-10-01 00:00:00
abstract：:We produced a B95a lymphoid cell line persistently infected with canine distemper virus (CDV), in which virus-specific antigens were present in nearly 100% of cells without causing cytopathic effect. The virus recovered from this cell line was able to infect fresh B95a cells persistently, indicating that a persistent ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(99)80516-4
更新日期：1999-10-01 00:00:00
abstract：:Despite the development of new treatments, the mortality due to invasive pulmonary aspergillosis remains above 50%, reaching 95% in certain situations. The battle against Aspergillus fumigatus involves several components of the pulmonary innate immune system: cells, mediators, and natural antifungal molecules involved...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2009.07.002
更新日期：2009-10-01 00:00:00
abstract：:The identification of Brachyspira hyodysenteriae outer membrane proteins (OMPs) that may stimulate immunity to swine dysentery is important for vaccine development. We report here the analysis of a novel locus, blpGFEA, encoding four tandem paralogous proteins of approximately 30 kDa from B. hyodysenteriae. The four p...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(03)00027-3
更新日期：2003-04-01 00:00:00
abstract：:Foot-and-mouth disease virus (FMDV) is a member of the Aphthovirus genus in the Picornaviridae family. Seven distinct serotypes, each including a wide range of variants, have been defined. FMD, affects wild and domesticated ruminants and pigs, is difficult to control and is the major constraint to international trade ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01634-9
更新日期：2002-08-01 00:00:00
abstract：:The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity. This report reviews our studies with Sylvio X10/4 parasites, a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to chronic myocarditis res...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2009.07.011
更新日期：2009-11-01 00:00:00
abstract：:Highly pathogenic Yersinia carry a pathogenicity island termed high-pathogenicity island (HPI). The Yersinia HPI comprises genes involved in the synthesis of the siderophore yersiniabactin and can thus be regarded as an iron-uptake island. A unique characteristic of the HPI is its wide distribution among different ent...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(01)01412-5
更新日期：2001-06-01 00:00:00
abstract：:Malaria is an infectious disease caused by parasites of the genus Plasmodium. This intraerythrocytic protozoan produces hemozoin (HZ), an insoluble crystalline metabolite resulting from the heme detoxification mechanism. This review will focus on HZ biosynthesis and synthetic preparation, but in particular on its effe...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2010.07.001
更新日期：2010-11-01 00:00:00
abstract：:Neisseria meningitidis is an opportunistic human pathogen that usually colonizes the nasopharyngeal mucosa asymptomatically. Upon invasion into the blood and central nervous system, this bacterium triggers a fulminant inflammatory reaction with the manifestations of septicemia and meningitis, causing high morbidity an...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.09.025
更新日期：2016-02-01 00:00:00
abstract：:This review summarizes and discusses virulence mechanisms whereby Porphyromonas gingivalis can persist in the oral cavity. It is proposed that the virulence of P. gingivalis is dependent, at least in part, upon its ability to establish a complex host-pathogen molecular crosstalk which subverts innate immunity. The sop...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2009.03.009
更新日期：2009-05-01 00:00:00
abstract：:The treatment of HEp-2 cells with sorbitol induced massive apoptosis rapidly. This method for inducing apoptosis is very useful to detect antiapoptotic activity of viruses as well as viral genes. Commitment to death occurred immediately upon incubation with sorbitol, even in the presence of pancaspase inhibitor, Z-VAD...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(00)00366-x
更新日期：2000-05-01 00:00:00
abstract：:Many intraerythrocytic hemoparasites survive the host immune system through rapid antigenic variation. Among babesial parasites antigenic variation has been demonstrated convincingly only for Babesia bovis and Babesia rodhaini. The molecular basis for antigenic variation in babesial parasites and its possible connecti...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(01)01404-6
更新日期：2001-05-01 00:00:00
abstract：:It has been appreciated for almost 20 years that members of the Chlamydiales possess a virulence-associated type III secretion mechanism. Given the obligate intracellular nature of these bacteria, defining exactly how type III secretion functions to promote pathogenesis has been challenging. We present a working model...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2015.10.006
更新日期：2016-02-01 00:00:00
abstract：:Tissue Factor (TF) is the initiator of coagulation and Tissue Factor Inhibitor (TFPI) is the physiological inhibitor of the TF/FVIIa complex. Circulating levels of TF and TFPI were quantified in dengue patients and the relationships with disease severity and infecting serotype analysed. A significant decrease in TF an...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2016.08.005
更新日期：2017-01-01 00:00:00
abstract：:Purging HIV-1 to cure the infection in patients undergoing suppressive antiretroviral therapy requires targeting all possible viral reservoirs. Other than the memory CD4(+) T cells, several other HIV-1 reservoirs have been identified. HIV-1 infection in the brain as a reservoir is well documented, but not fully charac...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.05.006
更新日期：2015-09-01 00:00:00
abstract：:BCG rectal administration to newborn and adult mice induced protective immune responses against tuberculosis. BCG reaches the sub-epithelial site and the draining mesenteric lymph nodes (MLNs), and dendritic cells (DC) could be recruited to these sites. Using polarized Caco-2 epithelial cells, we showed that BCG trans...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.03.022
更新日期：2006-08-01 00:00:00
abstract：:Although Pneumocystis carinii pneumonia is one of the leading causes of morbidity and mortality among patients with the acquired immunodeficiency syndrome, many questions about its epidemiology and transmission remain unanswered. Whereas traditional theory postulates that the disease results from reactivation of laten...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(01)01514-3
更新日期：2002-01-01 00:00:00
abstract：:Despite high vaccination coverage, pertussis remains an important respiratory infectious disease and the least-controlled vaccine-preventable infectious disease in children. Natural infection with Bordetella pertussis is known to induce strong and long-lasting immunity that wanes later than vaccine-mediated immunity. ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.10.002
更新日期：2014-01-01 00:00:00
abstract：:Using a viral-induced immunopathology model, we showed that when CD4(+) T cells were allowed to undergo homeostatic expansion prior to ocular herpes simplex virus infection, mice developed more severe inflammatory lesions with the increased severity associated with enhanced effector function of ocular CD4(+) T cells, ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.06.012
更新日期：2008-08-01 00:00:00
abstract：:Patients with paracoccidioidomycosis (PCM) present marked involvement of the lungs during the course of the mycosis. The purpose of this work was to obtain bronchoalveolar lavage (BAL) fluid from these patients to study the cytopathology, TNF levels and the oxidative and fungicidal response of alveolar macrophages (AM...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2003.05.001
更新日期：2003-12-01 00:00:00
abstract：:Salmonella, a Gram-negative facultative intracellular pathogen is capable of infecting vast array of hosts. The striking ability of Salmonella to overcome every hurdle encountered in the host proves that they are true survivors. In the host, Salmonella infects various cell types and needs to survive and replicate by c...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2010.05.010
更新日期：2010-10-01 00:00:00
abstract：:We investigated the epidemiology of antibiotic resistance and virulence properties among Pseudomonas aeruginosa clinical isolates collected in 1999 from patients hospitalized in the intensive care units of the centre hospitalier d'Orléans, in France. We compared the totality of the strains from mechanically ventilated...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(02)01579-4
更新日期：2002-05-01 00:00:00
abstract：:Few human pathogens possess the ability exhibited by Candida albicans to colonize and cause symptomatic infections at different body sites. The host immune system is the major factor determining whether this opportunistic yeast behaves as a commensal or as a pathogen, since C. albicans strains appear capable of expres...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.09.016
更新日期：2006-03-01 00:00:00
abstract：:Toxoplasma IgG and IgA, but not IgM, antibody titers were significantly higher in immunocompetent mice with cerebral proliferation of tachyzoites during the chronic stage of infection than those treated with sulfadiazine to inhibit the parasite growth. Their IgG and IgA antibody titers correlated significantly with th...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2010.07.016
更新日期：2010-12-01 00:00:00
