Abstract：
:Few human pathogens possess the ability exhibited by Candida albicans to colonize and cause symptomatic infections at different body sites. The host immune system is the major factor determining whether this opportunistic yeast behaves as a commensal or as a pathogen, since C. albicans strains appear capable of expressing similar virulence factors in response to specific body-district cues. This report provides evidence showing that C. albicans isolates with diverse genomic backgrounds (b and c karyotypes) differently modulate their pathogenic potential when assayed in cocultures with human monocytic derived macrophages (THP-1 cells). Striking differences were observed in the ability to undergo bud-hypha transition, a relevant C. albicans virulence factor, between b and c karyotypes (P<0.0001) upon their internalization by macrophages. All c types were able to develop hyphal forms, resist intracellular killing, replicate, and escape from macrophages. The b type isolates, which were shown to be more efficiently ingested by THP-1 cells than the c type strains (P=0.013), were susceptible to intracellular killing and predominantly found as blastoconidia inside macrophages. Despite their different intracellular disposition, both b and c type isolates were equally able to undergo morphogenesis and to express NRG1 and HWP1 genes, markers of the bud-hypha transition program, during in vitro propagation. Since macrophages play a critical role in the host resistance to C. albicans, the different response of b and c isolates to macrophage infection suggests that the c type strains are better suited to behave as a more virulent strain cluster.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Tavanti A,Campa D,Bertozzi A,Pardini G,Naglik JR,Barale R,Senesi Sdoi
10.1016/j.micinf.2005.09.016subject
Has Abstractpub_date
2006-03-01 00:00:00pages
791-800issue
3eissn
1286-4579issn
1769-714Xpii
S1286-4579(05)00367-9journal_volume
8pub_type
杂志文章abstract：:Motility is essential for Helicobacter pylori colonization. This review discusses the biochemistry, genetics and genomics of the H. pylori flagellum, and compares these features with well-characterized bacteria. ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)01274-0
更新日期：2000-08-01 00:00:00
abstract：:In this study, the effect of Yersinia derivatives on nitric oxide (NO), hydrogen peroxide (H2O2) and tumor necrosis factor-alpha (TNF-alpha) production by murine peritoneal macrophages was investigated. Addition of lipopolysaccharide (LPS) to the macrophage culture resulted in NO production that was dose dependent. On...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2003.10.012
更新日期：2004-02-01 00:00:00
abstract：:Several pathogens including Gram-negative bacteria hijack complement regulators to escape host's innate response. Pathogenic Leptospira species bind Factor H, C4b binding protein and vitronectin from the complement system. We evaluated the ability of low passage (LP) and culture-attenuated (CA) pathogenic strains of L...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2019.03.001
更新日期：2019-01-01 00:00:00
abstract：:Recent studies by DNA-DNA hybridisation assays conducted on a large collection of Escherichia coli strains isolated from chickens, ducks and turkeys suffering from colibacillosis, showed that 76% of the strains were negative for the presence of the pap gene cluster. The objective of this paper was to study the virulen...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.03.006
更新日期：2004-06-01 00:00:00
abstract：:Several glycoforms of CD43 are known to regulate cellular interactions in the immune system. One such glycoform, the CD43 that bears core 2 O-glycans, is also known to be expressed on T lymphocytes and natural killer cells, but only after their activation. Previous studies have also shown that when Caco-2 cells, which...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(01)01431-9
更新日期：2001-07-01 00:00:00
abstract：:Paracoccidioidomycosis is a systemic mycosis endemic to Latin America. The infection is initiated by inhalation of conidia into the lung and may develop as localized or disseminated disease depending on the depression of cellular immunity. In the present study, we observed that intratracheal infection with Paracoccidi...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2016.08.001
更新日期：2016-12-01 00:00:00
abstract：:Immature dendritic cells (Dcs) are characterised by high antigen uptake ability and poor T-cell stimulatory function. In contrast, mature DCs have a high stimulatory function and poor antigen uptake ability. Inflammatory stimuli induce DC maturation and migration from nonlymphoid tissues to lymphoid organs. We investi...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(99)00209-9
更新日期：1999-11-01 00:00:00
abstract：:The immune response, both in innate and adaptive immunity, is controlled at several levels, including signaling from the central nervous system. Neuropeptides released within the lymphoid organs modulate the immune response, either as stimulators or inhibitors. The subject of this review is the description of macropha...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)01361-7
更新日期：2001-02-01 00:00:00
abstract：:Novel coronavirus disease 2019 (COVID-19) pandemic is the most recent health care crisis without specific prophylactic or therapeutic drugs. Antimalarial drug chloroquine (CHL) and its safer derivative hydroxychloroquine (HCHL) have been proposed to be repurposed to treat SARS coronavirus-2 (SARS-CoV-2), the causative...
journal_title：Microbes and infection
pub_type： 信件
doi：10.1016/j.micinf.2020.04.004
更新日期：2020-01-01 00:00:00
abstract：:Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticat...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2009.10.002
更新日期：2010-02-01 00:00:00
abstract：:This study examined the impact of concurrent parasite infections (amoebiasis, filariasis, necatoriasis) and the effect of anti-parasite treatment on cytokine and chemokine responses in singly and poly-parasitized patients. Cellular reactivity and parasite-specific Th1- and Th2-type cytokine and chemokine profiles were...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.06.019
更新日期：2006-01-01 00:00:00
abstract：:The differential recognition of fungal cell wall polysaccharides that program innate and adaptive immunity to the human opportunistic fungal pathogen Aspergillus fumigatus has been a focus of considerable interest. In a mouse model of fungal conidia aspiration, decreased relative levels of cell wall core carbohydrates...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2017.05.001
更新日期：2017-01-01 00:00:00
abstract：:Two strains of mice selected according to extreme phenotypes of susceptibility and resistance to oral tolerance (TS and TR mice, respectively) were infected with 1 x 10(7) Leishmania amazonensis promastigotes and studied comparatively. TS mice developed a minor pathology while permitting parasite growth with the prese...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.09.018
更新日期：2006-04-01 00:00:00
abstract：:The primary purpose of preoperative dental screening of medical patients is to detect acute or chronic oral conditions that may require management prior to planned medical interventions. The aim of this communication is to discuss the background of preoperative dental screening and the link between dental pathologies ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2016.10.002
更新日期：2017-02-01 00:00:00
abstract：:Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the inf...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2010.05.007
更新日期：2010-10-01 00:00:00
abstract：:CCR5-tropic (R5) immunodeficiency virus type 1 (HIV-1) strains are highly transmissible during the early stage of infection in humans, whereas CXCR4-tropic (X4) strains are less transmissible. This study aimed to explore the basis for early phase R5 and X4 HIV-1 infection in vivo by using humanized mice dually challen...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.02.002
更新日期：2015-05-01 00:00:00
abstract：:Novel vaccines are needed to control tuberculosis (TB), the bacterial infectious disease that together with malaria and HIV is worldwide responsible for high levels of morbidity and mortality. TB can result from the reactivation of an initially controlled latent infection by Mycobacterium tuberculosis (Mtb). Mtb prote...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2011.08.011
更新日期：2012-01-01 00:00:00
abstract：:Memory T cells are derived directly from effector cells without need for additional antigen, TcR triggering or induced cytokines. A large fraction of effectors can become memory cells without division, supporting a default pathway with little further differentiation. This suggests that the same signals during infectio...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(03)00013-3
更新日期：2003-03-01 00:00:00
abstract：:Episomal expression of the major surface glycoprotein (gp63) sense and antisense mRNAs in Leishmania amazonensis was found previously to modulate the expression of this molecule as well as its infection of macrophages in vitro. Here, we evaluated the in vivo infectivity of these transfectants in BALB/c mice. Antisense...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.01.006
更新日期：2006-05-01 00:00:00
abstract：:The early interferon-gamma (IFN-gamma) response after Salmonella infection was compared in resistant and susceptible congenic mice strains differing by the allele of Nramp1. IFN-gamma gene expression in vivo was studied by quantitative reverse transcription-PCR performed from the spleen of mice challenged by Salmonell...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(01)01419-8
更新日期：2001-07-01 00:00:00
abstract：:Intramuscular immunization with DNA vaccines has been shown to induce a broad range of immune responses and protective immunity in many animal models, but it is less effective in primates. One reason for this may be the low expression of vector-encoded antigen in cells. Here we report that the use of vaccine vector (p...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.06.010
更新日期：2006-09-01 00:00:00
abstract：:Yersiniabactin (Ybt) is a siderophore-dependent iron uptake system encoded on a pathogenicity island that is widespread among pathogenic bacteria including the Yersiniae. While biosynthesis of the siderophore has been elucidated, the secretion mechanism and a few components of the uptake/utilization pathway are uniden...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2011.04.008
更新日期：2011-09-01 00:00:00
abstract：:Conventional cell lines are commonly used to study infection characteristics of the human gastric pathogen Helicobacter pylori. We sought to investigate bacterial attachment to human antral primary epithelial cells, a cell model that more closely resembles the human stomach than transformed cell lines. Primary cells w...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(00)01322-8
更新日期：2000-11-01 00:00:00
abstract：:Ebolavirus can cause a highly fatal and panic-generating human disease which may jump from bats to other mammals and human. High viral loads in body fluids allow efficient transmission by contact. Lack of effective antivirals, vaccines and public health infrastructures in parts of Africa make it difficult to health wo...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2014.11.007
更新日期：2015-02-01 00:00:00
abstract：:Infection of colonic epithelial cells by Shigella is associated with the type III secretion system, which serves as a molecular syringe to inject effectors into host cells. This system includes an extracellular needle used as a conduit for secreted proteins. Two of these proteins, IpaB and IpaD, dock at the needle tip...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2014.03.010
更新日期：2014-07-01 00:00:00
abstract：:Cytokines are increasingly recognized as important components of the cellular immune responses to intracellular pathogens. In this study, we analyzed the production of TGF-beta, IL-10 and IFN-gamma by PBMC of unexposed naïve subjects and LCL patients after stimulation with live Leishmania guyanensis (L.g.). We demonst...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.04.009
更新日期：2007-07-01 00:00:00
abstract：:The PE and PPE family of proteins of Mycobacterium tuberculosis have been hypothesized to play important roles in the biology of the organism and some proteins have been shown to be involved in eliciting T-cell responses. Earlier, we had identified putative HLA class I binding epitopes of the PE and PPE proteins of My...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.04.017
更新日期：2008-07-01 00:00:00
abstract：:AIDS patients frequently exhibit neurological disorders due to the neurotoxic events that result from HIV-1 and/or opportunistic infections in the brain. This review examines recent clinical findings related to HIV-1-associated dementia, and outlines current areas of basic research that may clarify how HIV-1-associate...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01542-3
更新日期：2002-03-01 00:00:00
abstract：:Parasites of the Leishmania genus are the causative agents of a complex disease called leishmaniasis. Many activities of infected cells including their responses to a range of stimuli are modulated by Leishmania parasites. This review will profile some of the parasite molecules that target host cell processes for whic...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2014.07.012
更新日期：2014-09-01 00:00:00
abstract：:In experimental Trypanosoma cruzi infections, severe thymic atrophy leads to release of activated CD4(+)CD8(+) double-positive (DP) T cells to the periphery. In humans, activated DP T cells are found in the blood in association with severe cardiac forms of human chronic Chagas disease. The mechanisms underlying the pr...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.02.003
更新日期：2013-05-01 00:00:00
