Abstract：
:Cytokines are increasingly recognized as important components of the cellular immune responses to intracellular pathogens. In this study, we analyzed the production of TGF-beta, IL-10 and IFN-gamma by PBMC of unexposed naïve subjects and LCL patients after stimulation with live Leishmania guyanensis (L.g.). We demonstrated that IFN-gamma is produced in controls and LCL patients, IL-10 only in LCL patients and TGF-beta only in naïve subjects. Furthermore, in naive subjects, neutralization of TGF-beta induced IL-10 production. IL-10 produced in naïve subjects when TGF-beta is neutralized or in LCL patients did not modify the IFN-gamma production but inhibit reactive nitrogen species production. Analysis of the phenotype of IL-10 producing cells in naive subjects when TGF-beta is neutralized clearly showed that they are memory CD45RA- CD8+ T cells. In LCL patients, IL-10 producing cells are both CD45RA- CD4 and CD8+ T cells. The role of these IL-10 producing CD8+ T cells in the development of the diseases should be carefully evaluated.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Bourreau E,Ronet C,Couppié P,Sainte-Marie D,Tacchini-Cottier F,Launois Pdoi
10.1016/j.micinf.2007.04.009subject
Has Abstractpub_date
2007-07-01 00:00:00pages
1034-41issue
8eissn
1286-4579issn
1769-714Xpii
S1286-4579(07)00173-6journal_volume
9pub_type
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