Mammalian RNA virus-derived small RNA: biogenesis and functional activity.

abstract：:Orientia tsutsugamushi, an obligate intracellular bacterium, was isolated for the first time in 1930. Infections by virulent strains are characterized by fever, rash, eschar, pneumonia, myocarditis, and disseminated intravascular coagulation. Here we review the general aspects of O. tsutsugamushi and immune responses ...

journal_title：Microbes and infection

authors： Seong SY,Choi MS,Kim IS

更新日期：2001-01-01 00:00:00

abstract：:Mathematical models of the dynamics of HIV and hepatitis C virus infection have proven to be of great utility in understanding pathogenesis and designing better treatments. Here, we review the state of the art in modeling and interpreting data obtained from hepatitis B virus infected patients treated with antiviral ag...

journal_title：Microbes and infection

authors： Ribeiro RM,Lo A,Perelson AS

更新日期：2002-07-01 00:00:00

abstract：:Helicobacter pylori infection induces chronic inflammation in the gastric mucosa with a marked increase in the number of lymphoid follicles consisting of infiltrating B and T cells, neutrophils, dendritic cells (DC) and macrophages. It has been suggested that an accumulation of mature DC in the tissue, resulting from ...

journal_title：Microbes and infection

authors： Hansson M,Lundgren A,Elgbratt K,Quiding-Järbrink M,Svennerholm AM,Johansson EL

更新日期：2006-03-01 00:00:00

abstract：:This review considers whether the products of schistosomes in the mammalian host can be considered as virulence factors. These include: the cercarial secretions used in infection, those of the migrating schistosomulum, surface-exposed proteins of adult worms in the portal system and their gut vomitus in the context of...

journal_title：Microbes and infection

authors： Wilson RA

更新日期：2012-12-01 00:00:00

abstract：:Grain feeding seems to promote the growth and acid resistance of Escherichia coli in fattening beef cattle, and acid-resistant E. coli are more likely to survive the human gastric stomach. When cattle were fed hay for only five days, the number and acid resistance of E. coli decreased dramatically. ...

journal_title：Microbes and infection

authors： Russell JB,Diez-Gonzalez F,Jarvis GN

更新日期：2000-01-01 00:00:00

abstract：:Phagocytosis is important in immune defense and development in vertebrates and invertebrates. It leads to swift ingestion of microorganisms and dying cells by phagocytes. How particles are recognized is not well understood. Studies in insects, and Drosophila in particular, argue that these are powerful model systems t...

journal_title：Microbes and infection

authors： Franc NC,White K

更新日期：2000-03-01 00:00:00

abstract：:Neisseria meningitidis, an exclusive pathogen of humans, remains the leading worldwide cause of meningitis and fatal sepsis, usually in otherwise healthy individuals. In recent years, significant advances have improved our understanding of the epidemiology and genetic basis of meningococcal disease and led to progress...

journal_title：Microbes and infection

authors： Tzeng YL,Stephens DS

更新日期：2000-05-01 00:00:00

abstract：:Several bacterial pathogens interact with their host through protein secretion effectuated by a type VI secretion system (T6SS). Francisella tularensis is a highly pathogenic intracellular bacterium that causes the disease tularemia. Proteins encoded by the Francisella pathogenicity island (FPI), which constitute a ty...

journal_title：Microbes and infection

authors： Ozanic M,Marecic V,Lindgren M,Sjöstedt A,Santic M

更新日期：2016-12-01 00:00:00

abstract：:Receptor-mediated endocytosis is known to play an important role in the entry of many viruses into host cells. However, the exact internalization mechanism has, until recently, remained poorly understood for many medically important viruses, including influenza. Developments in real-time imaging of single viruses as w...

journal_title：Microbes and infection

authors： Lakadamyali M,Rust MJ,Zhuang X

更新日期：2004-08-01 00:00:00

abstract：:Lipoarabinomannans (LAMs) from mycobacteria were investigated concerning their effect on human neutrophils. Two types of LAM, the mannose-capped ManLAM from the virulent Mycobacterium tuberculosis H37Rv and the mannose-lacking AraLAM from a rapidly growing mycobacterial strain were used. Neither AraLAM nor ManLAM indu...

journal_title：Microbes and infection

authors： Fäldt J,Dahlgren C,Ridell M,Karlsson A

更新日期：2001-11-01 00:00:00

abstract：:Porcine respiratory coronavirus (PRCV) potentiates respiratory disease and proinflammatory cytokine production in the lungs upon intratracheal inoculation with lipopolysaccharide (LPS) at 1 day of infection. This study aimed to quantify LPS-binding protein (LBP), CD14 and haptoglobin in the lungs throughout a PRCV inf...

journal_title：Microbes and infection

authors： Van Gucht S,Atanasova K,Barbé F,Cox E,Pensaert M,Van Reeth K

更新日期：2006-05-01 00:00:00

abstract：:Campylobacter jejuni is the predominant cause of antecedent infection in Guillain-Barré syndrome (GBS) or Miller Fisher syndrome (MFS). C. jejuni probably triggers GBS or MFS through molecular mimicry between bacterial sialylated lipo-oligosaccharides (LOS) and gangliosides in peripheral nerve tissue. We investigated ...

journal_title：Microbes and infection

authors： Godschalk PC,Gilbert M,Jacobs BC,Kramers T,Tio-Gillen AP,Ang CW,Van den Braak N,Li J,Verbrugh HA,Van Belkum A,Endtz HP

更新日期：2006-01-01 00:00:00

abstract：:Overlapping peptides of different lengths from a certain immunodominant region can be presented by the same HLA class I molecule and elicit different T cell responses. However, how peptide-length specificity of antigen-specific CD8(+) T lymphocytes influence cross-reactivity profiles of these cells remains elusive. Th...

journal_title：Microbes and infection

authors： Motozono C,Yokoyama M,Sato H,Ueno T

更新日期：2014-04-01 00:00:00

abstract：:Recombinant BCG strain that secretes the chimaeric protein of Ag85B and ESAT-6 has been demonstrated to augment Th1 immune response in C57BL/6 mice. In this paper, we studied the immunostimulatory activity of the recombinant BCG strains in vitro and found out that rBCG-A(N)-E-A(C) activated THP-1 cells and induced hig...

journal_title：Microbes and infection

authors： Xu Y,Liu W,Shen H,Yan J,Yang E,Wang H

更新日期：2010-08-01 00:00:00

abstract：:Moraxella catarrhalis has again been recognized as a significant pathogen. The past decade has witnessed an increased amount of research and understanding of the pathogenesis of the organism. This review will summarize the research pertaining to the epidemiology and components of pathogenesis in M. catarrhalis. ...

journal_title：Microbes and infection

authors： Karalus R,Campagnari A

更新日期：2000-04-01 00:00:00

abstract：:Pathogenic Leptospira species are the causative agents of leptospirosis, a global zoonotic infectious disease. Toxin-antitoxin (TA) modules have been confirmed as stress-response elements that induce prokaryotic and eukaryotic cell-growth arrest or death, but their role in the virulence of Leptospira has not been repo...

journal_title：Microbes and infection

authors： Komi KK,Ge YM,Xin XY,Ojcius DM,Sun D,Hu WL,Zhao X,Lin X,Yan J

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to investigate the in vitro antiviral properties of pterocarnin A, extracted from the bark of Pterocarya stenoptera (Juylandaceae). Results showed that pterocarnin A exhibited anti-herpes simplex virus (HSV) activity. It had a low selectivity index (SI) value and only possessed some level...

journal_title：Microbes and infection

authors： Cheng HY,Lin TC,Yang CM,Wang KC,Lin CC

更新日期：2004-07-01 00:00:00

abstract：:Amoebiasis is responsible for 50000-100000 deaths annually. Invasive amoebic disease begins with the attachment of Entamoeba histolytica trophozoites to colonic mucin, a process mediated by the amoebic Gal/GalNAc lectin. The non-pathogenic counterpart, E. dispar, is morphologically identical but genetically distinct. ...

journal_title：Microbes and infection

authors： Pillai DR,Kain KC

更新日期：2000-11-01 00:00:00

abstract：:Our previous study has demonstrated that IL-10 may modulate both indoleamine 2,3-dioxygenase (IDO) and CD163 expression in lepromatous leprosy (LL) cells, favoring Mycobacterium leprae persistence through induction of regulatory pathways and iron storage. Here, we observed that in LL lesion cells there is an increase ...

journal_title：Microbes and infection

authors： de Mattos Barbosa MG,da Silva Prata RB,Andrade PR,Ferreira H,de Andrade Silva BJ,da Paixão de Oliveira JA,Assis TQ,de Toledo-Pinto TG,de Lima Bezerra OC,da Costa Nery JA,Rosa PS,Bozza MT,Lara FA,Moraes MO,Schmitz V,Sarno EN

更新日期：2017-11-01 00:00:00

abstract：:Major advances have recently been achieved in the area of microbial recognition by the innate immune system. In this Forum, we discuss important issues related to innate recognition of bacteria and protozoan parasites. In particular, we highlight the structural characterization of pathogen-associated molecular pattern...

journal_title：Microbes and infection

authors： Teixeira MM,Almeida IC,Gazzinelli RT

更新日期：2002-07-01 00:00:00

abstract：:Because of its severe side effects and variable efficacy, the current treatment for Chagas disease is unsatisfactory. Natural compounds are good alternative chemotherapeutic agents for the treatment of this infection. Recently, our group reported the antiproliferative activity and morphological alterations in epimasti...

journal_title：Microbes and infection

authors： Pelizzaro-Rocha KJ,Veiga-Santos P,Lazarin-Bidóia D,Ueda-Nakamura T,Dias Filho BP,Ximenes VF,Silva SO,Nakamura CV

更新日期：2011-11-01 00:00:00

abstract：:Recent studies by DNA-DNA hybridisation assays conducted on a large collection of Escherichia coli strains isolated from chickens, ducks and turkeys suffering from colibacillosis, showed that 76% of the strains were negative for the presence of the pap gene cluster. The objective of this paper was to study the virulen...

journal_title：Microbes and infection

authors： Stordeur P,Brée A,Mainil J,Moulin-Schouleur M

更新日期：2004-06-01 00:00:00

abstract：:African trypanosomes (prototype: Trypanosoma brucei) are flagellated protozoan parasites that infect a wide variety of mammals, causing nagana in cattle and sleeping sickness in humans. These organisms can cause prolonged chronic infections due to their ability to successively expose different antigenic variants of th...

journal_title：Microbes and infection

authors： Pays E

更新日期：2006-03-01 00:00:00

abstract：:The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity. This report reviews our studies with Sylvio X10/4 parasites, a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to chronic myocarditis res...

journal_title：Microbes and infection

authors： Marinho CR,Nuñez-Apaza LN,Bortoluci KR,Bombeiro AL,Bucci DZ,Grisotto MG,Sardinha LR,Jorquera CE,Lira S,Lima MR,Alvarez JM

更新日期：2009-11-01 00:00:00

abstract：:Campylobacter jejuni and Campylobacter coli together represent the leading bacterial cause of human enteritis. However, the pathogenesis of this disease is poorly understood. Infection results in the formation of crypt abscesses resulting from the migration of neutrophils across the intestinal epithelium and into the ...

journal_title：Microbes and infection

authors： Murphy H,Cogan T,Humphrey T

更新日期：2011-01-01 00:00:00

abstract：:Attenuated pre-erythrocytic stage malaria vaccines protect humans from sporozoite challenge. Current technology limits the feasibility of their commercial scale production and poses a significant risk of contamination with transmissible agents. Overcoming these barriers will be very challenging. In contrast, subunit v...

journal_title：Microbes and infection

authors： Ripley Ballou W

更新日期：2007-05-01 00:00:00

abstract：:We produced a B95a lymphoid cell line persistently infected with canine distemper virus (CDV), in which virus-specific antigens were present in nearly 100% of cells without causing cytopathic effect. The virus recovered from this cell line was able to infect fresh B95a cells persistently, indicating that a persistent ...

journal_title：Microbes and infection

authors： Iwatsuki K,Ikeda Y,Ohashi K,Nakamura K,Kai C

更新日期：1999-10-01 00:00:00

abstract：:Infectious diseases are major causes, with malignancies, of morbidity and mortality in the elderly. Increased susceptibility to infections may result from underlying dysfunction of an aged immune system; moreover, inappropriate immunologic functions associated with aging can determine an insufficient response to vacci...

journal_title：Microbes and infection

authors： Ginaldi L,Loreto MF,Corsi MP,Modesti M,De Martinis M

更新日期：2001-08-01 00:00:00

abstract：:Anaerobic bacteria can cause a variety of endogenous infections in children. Because of their fastidious nature, they are difficult to isolate from infectious sites, and are often overlooked. Anaerobic infections can occur in all body sites, including the central nervous system, oral cavity, head and neck, chest, abdo...

journal_title：Microbes and infection

authors： Brook I

更新日期：2002-10-01 00:00:00

abstract：:This study used a murine model of type 2 diabetes (BKS.Cg-Dock7(m) +/+Lepr(db)/J mice) to investigate the inflammatory and cellular mechanisms predisposing to Burkholderia pseudomallei infection and co-morbid diabetes. Homozygous db/db (diabetic) mice developed extreme obesity, dyslipidaemia and glucose intolerance le...

journal_title：Microbes and infection

authors： Hodgson KA,Morris JL,Feterl ML,Govan BL,Ketheesan N

更新日期：2011-12-01 00:00:00