Abstract：
:Infection with Trypanosoma cruzi, the etiologic agent in Chagas disease, may result in heart disease. Over the last decades, Chagas disease endemic areas in Latin America have seen a dietary transition from the traditional regional diet to a Western style, fat rich diet. Previously, we demonstrated that during acute infection high fat diet (HFD) protects mice from the consequences of infection-induced myocardial damage through effects on adipogenesis in adipose tissue and reduced cardiac lipidopathy. However, the effect of HFD on the subsequent stages of infection - the indeterminate and chronic stages - has not been investigated. To address this gap in knowledge, we studied the effect of HFD during indeterminate and chronic stages of Chagas disease in the mouse model. We report, for the first time, the effect of HFD on myocardial inflammation, vasculopathy, and other types of dysfunction observed during chronic T. cruzi infection. Our results show that HFD perturbs lipid metabolism and induces oxidative stress to exacerbate late chronic Chagas disease cardiac pathology.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Lizardo K,Ayyappan JP,Cui MH,Balasubramanya R,Jelicks LA,Nagajyothi JFdoi
10.1016/j.micinf.2018.07.001subject
Has Abstractpub_date
2019-01-01 00:00:00pages
63-71issue
1eissn
1286-4579issn
1769-714Xpii
S1286-4579(18)30146-1journal_volume
21pub_type
杂志文章abstract：:Currently, there is no specific antiviral therapy for HPV infection. We conducted a randomized open-label clinical trial of JB01-BD, an anti-HPV biological dressing from Shanxi Jinbo Pharmaceutical Co., Ltd., China, for treatment of HPV infection. Seventy-seven women with cervical infection by high-risk HPV were rando...
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更新日期：2015-11-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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