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Viral inhibitors reveal overlapping themes in regulation of cell death and innate immunity.

Abstract：

:Many viruses regulate a crucial point in the apoptotic pathway by expressing viral Bcl-2 homologues, which have become useful tools to investigate the mechanisms behind the control of the mitochondrial checkpoint of apoptosis. Concurrently, a number of viral inhibitors of innate immune signalling have been instrumental tools in the discovery of key host pathways. Here we discuss how viral inhibitors of the apoptotic and innate signalling pathways have further enhanced the understanding of both research fields and are beginning to shed light on how these two pathways converge.

journal_name

Microbes Infect

journal_title

Microbes and infection

authors

Postigo A,Ferrer PE

doi

10.1016/j.micinf.2009.08.012

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

1071-8

issue

13

eissn

1286-4579

issn

1769-714X

pii

S1286-4579(09)00203-2

journal_volume

11

pub_type

杂志文章,评审

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