当前位置： SCI文献检索 > MICROBES AND INFECTION期刊下所有文献 > Emerging multidrug resistant Mycobacterium tuberculosis strains of the Beijing genotype circulating in Russia express a pattern of biological properties associated with enhanced virulence.

Emerging multidrug resistant Mycobacterium tuberculosis strains of the Beijing genotype circulating in Russia express a pattern of biological properties associated with enhanced virulence.

Abstract：

:The epidemiologically important Mycobacterium tuberculosis Beijing genotype strains, highly endemic in East Asia, have become an emerging infection in certain geographic areas, including Russia, because of its increasing prevalence and association with multidrug resistance (MDR). The aim was to verify whether MDR Beijing strains circulating in the emerging regions present some biological particularities that could contribute to their success in causing disease in comparison with the sporadic strains from locations with low prevalence of the Beijing genotype. We evaluated virulence-associated characteristics of the MDR Beijing strains isolated in Russia and compared them with those of the drug-resistant and susceptible Beijing strains from Brazil and reference H37Rv strain. We found that Russian MDR strains demonstrated an increased bacterial fitness and growth in THP-1 macrophage-like cells, as well as a higher capacity to induce non-protective cytokine synthesis and necrotic macrophage death. By contrast, the biological properties of the strains isolated in Brazil largely resembled those of the H37Rv strain, with the exception of the drug-resistant isolates that presented significantly reduced fitness. The data demonstrate that the emerging MDR strains of the Beijing genotype circulating in Russia do express a pattern of properties associated with the enhanced virulence favouring its clonal dissemination in this region.

journal_name

Microbes Infect

journal_title

Microbes and infection

authors

Lasunskaia E,Ribeiro SC,Manicheva O,Gomes LL,Suffys PN,Mokrousov I,Ferrazoli L,Andrade MR,Kritski A,Otten T,Kipnis TL,da Silva WD,Vishnevsky B,Oliveira MM,Gomes HM,Baptista IF,Narvskaya O

doi

10.1016/j.micinf.2010.02.008

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

467-75

issue

6

eissn

1286-4579

issn

1769-714X

pii

S1286-4579(10)00069-9

journal_volume

12

pub_type

杂志文章

相关文献

MICROBES AND INFECTION文献大全
  • Homeostatic expansion of CD4(+) T cells upregulates VLA-4 and exacerbates HSV-induced corneal immunopathology.

    abstract：:Using a viral-induced immunopathology model, we showed that when CD4(+) T cells were allowed to undergo homeostatic expansion prior to ocular herpes simplex virus infection, mice developed more severe inflammatory lesions with the increased severity associated with enhanced effector function of ocular CD4(+) T cells, ...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2008.06.012

    authors： Suvas S,Kim B,Rouse BT

    更新日期：2008-08-01 00:00:00

  • Induction of systemic and mucosal immune response and decrease in Streptococcus pneumoniae colonization by nasal inoculation of mice with recombinant lactic acid bacteria expressing pneumococcal surface antigen A.

    abstract：:Mucosal epithelia constitute the first barriers to be overcome by pathogens during infection. The induction of protective IgA in this location is important for the prevention of infection and can be achieved through different mucosal immunization strategies. Lactic acid bacteria have been tested in the last few years ...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2005.10.020

    authors： Oliveira ML,Arêas AP,Campos IB,Monedero V,Perez-Martínez G,Miyaji EN,Leite LC,Aires KA,Lee Ho P

    更新日期：2006-04-01 00:00:00

  • Obstacles to the development of a safe and effective attenuated pre-erythrocytic stage malaria vaccine.

    abstract：:Attenuated pre-erythrocytic stage malaria vaccines protect humans from sporozoite challenge. Current technology limits the feasibility of their commercial scale production and poses a significant risk of contamination with transmissible agents. Overcoming these barriers will be very challenging. In contrast, subunit v...

    journal_title：Microbes and infection

    pub_type： 杂志文章,评审

    doi：10.1016/j.micinf.2007.02.006

    authors： Ripley Ballou W

    更新日期：2007-05-01 00:00:00

  • Leishmania parasites: could we consider them as living organisms per se?

    abstract：:Over the last 10 years - in Microbes and Infection - the publications dealing with protozoan parasites were mainly providing insights on the pathogenic processes leading to the local or systemic damages in the mammals, these parasitic organisms exploit/subvert as hosts. As a result, many investigators introduced the o...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2008.07.009

    authors： Milon G

    更新日期：2008-07-01 00:00:00

  • Expression of HIV-1 accessory protein Vif is controlled uniquely to be low and optimal by proteasome degradation.

    abstract：:While the Vif protein of human immunodeficiency virus type 1 (HIV-1) is essential for viral replication in non-permissive cells, it is rapidly degraded intracellularly. We have previously suggested that the rapid turn-over of Vif is biologically meaningful to prevent detrimental effects of this protein at high express...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2004.04.011

    authors： Fujita M,Akari H,Sakurai A,Yoshida A,Chiba T,Tanaka K,Strebel K,Adachi A

    更新日期：2004-07-01 00:00:00

  • Mechanism of action of the suppression of herpes simplex virus type 2 replication by pterocarnin A.

    abstract：:The purpose of this study was to investigate the in vitro antiviral properties of pterocarnin A, extracted from the bark of Pterocarya stenoptera (Juylandaceae). Results showed that pterocarnin A exhibited anti-herpes simplex virus (HSV) activity. It had a low selectivity index (SI) value and only possessed some level...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2004.03.009

    authors： Cheng HY,Lin TC,Yang CM,Wang KC,Lin CC

    更新日期：2004-07-01 00:00:00

  • The incidence of Streptococcus pneumoniae otitis media is affected by the polymicrobial environment particularly Moraxella catarrhalis in a mouse nasal colonisation model.

    abstract：:Otitis media (OM) is a highly prevalent paediatric disease with both bacterial and viral triggers of infection. This study has investigated how combinations of bacteria associated with nasal colonisation and the occurrence and absence of viral infection (Sendai virus) induce OM in a mouse nasal colonisation model. The...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2009.03.001

    authors： Krishnamurthy A,McGrath J,Cripps AW,Kyd JM

    更新日期：2009-04-01 00:00:00

  • The role of cGMP signalling in regulating life cycle progression of Plasmodium.

    abstract：:The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue i...

    journal_title：Microbes and infection

    pub_type： 杂志文章,评审

    doi：10.1016/j.micinf.2012.04.011

    authors： Hopp CS,Bowyer PW,Baker DA

    更新日期：2012-08-01 00:00:00

  • Early events in dendritic cell maturation induced by LPS.

    abstract：:Immature dendritic cells (Dcs) are characterised by high antigen uptake ability and poor T-cell stimulatory function. In contrast, mature DCs have a high stimulatory function and poor antigen uptake ability. Inflammatory stimuli induce DC maturation and migration from nonlymphoid tissues to lymphoid organs. We investi...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/s1286-4579(99)00209-9

    authors： Granucci F,Ferrero E,Foti M,Aggujaro D,Vettoretto K,Ricciardi-Castagnoli P

    更新日期：1999-11-01 00:00:00

  • Pretreatment with the Gram-positive bacterial cell wall molecule peptidoglycan improves bacterial clearance and decreases inflammation and mortality in mice challenged with Pseudomonas aeruginosa.

    abstract：:The objective of this study was to determine if inflammatory tolerance and enhancement of innate immune function could be induced by the Gram-positive cell wall component peptidoglycan (PGN). Male mice (C57BL6/J or C3H/HeJ, 8-12 weeks of age) were given intraperitoneal injections of 1mg PGN on 2 consecutive days. The ...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2008.07.021

    authors： Murphey ED,Sherwood ER

    更新日期：2008-10-01 00:00:00

  • Approach for classification and taxonomy within family Rickettsiaceae based on the Formal Order Analysis.

    abstract：:Genome sequences of 36 Rickettsia and Orientia were analyzed using Formal Order Analysis (FOA). This approach takes into account arrangement of nucleotides in each sequence. A numerical characteristic, the average distance (remoteness) - "g" was used to compare of genomes. Our results corroborated previous separation ...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2015.09.012

    authors： Shpynov S,Pozdnichenko N,Gumenuk A

    更新日期：2015-11-01 00:00:00

  • Cellular aspects of Burkholderia cepacia infection.

    abstract：:The Gram-negative bacterium Burkholderia cepacia has recently emerged as an important opportunistic pathogen in humans. This review focuses on the cellular aspects of B. cepacia infection and the dynamics of the B. cepacia-host cell interaction, including recent advances in our understanding of the ability of B. cepac...

    journal_title：Microbes and infection

    pub_type： 杂志文章,评审

    doi：10.1016/s1286-4579(01)01389-2

    authors： Mohr CD,Tomich M,Herfst CA

    更新日期：2001-04-01 00:00:00

  • Differential roles of the co-stimulatory molecules GITR and CTLA-4 in the immune response to Trichinella spiralis.

    abstract：:We investigated the roles of the regulatory molecules glucocorticoid-induced TNF receptor family-related protein (GITR) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) in murine infection with the nematode parasite Trichinella spiralis. Expression of GITR and CTLA-4 was rapidly upregulated on cells in the mes...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2006.08.013

    authors： Furze RC,Culley FJ,Selkirk ME

    更新日期：2006-10-01 00:00:00

  • Adhesion molecules and cytokine profile in ileal tissue of sheep infected with Mycobacterium avium subsp. paratuberculosis.

    abstract：:Sheep develop clinical diseases after 3-5 years after infection with Mycobacterium avium subsp. paratuberculosis (MAP). Clinical symptoms of paratuberculosis include persistent diarrhea and weight loss due to a chronic inflammation of the small intestine. Tissue alterations in the areas of the ileo-cecal junction are ...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2009.04.006

    authors： Rossi G,Nigro G,Tattoli I,Vincenzetti S,Mariani P,Magi GE,Renzoni G,Taccini E,Bernardini ML

    更新日期：2009-05-01 00:00:00

  • Nucleoside-diphosphate-kinase: a pleiotropic effector in microbial colonization under interdisciplinary characterization.

    abstract：:Emerging evidence identifies multiple roles for nucleoside-diphosphate-kinase in host-microbe interaction. We provide the first synopsis of utilization of this molecule by various microorganisms during colonization of host tissues. Additionally, we propose novel mechanisms this effector may participate in, which could...

    journal_title：Microbes and infection

    pub_type： 杂志文章,评审

    doi：10.1016/j.micinf.2011.10.002

    authors： Spooner R,Yilmaz Ö

    更新日期：2012-03-01 00:00:00

  • Lung eosinophil recruitment in response to Aspergillus fumigatus is correlated with fungal cell wall composition and requires γδ T cells.

    abstract：:The differential recognition of fungal cell wall polysaccharides that program innate and adaptive immunity to the human opportunistic fungal pathogen Aspergillus fumigatus has been a focus of considerable interest. In a mouse model of fungal conidia aspiration, decreased relative levels of cell wall core carbohydrates...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2017.05.001

    authors： Amarsaikhan N,O'Dea EM,Tsoggerel A,Templeton SP

    更新日期：2017-01-01 00:00:00

  • B-1 cells upregulate CD8 T lymphocytes and increase proinflammatory cytokines serum levels in oral encephalitozoonosis.

    abstract：:Microsporidia are intracellular pathogens that cause severe disease in immunocompromised humans and animals. We recently demonstrated that XID mice are more susceptible to Encephalitozoon cuniculi infection by intraperitoneal route, evidencing the role of B-1 cells in resistance against infection. The present study in...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2017.11.004

    authors： Langanke Dos Santos D,Alvares-Saraiva AM,Xavier JG,Spadacci-Morena DD,Peres GB,Dell'Armelina Rocha PR,Perez EC,Lallo MA

    更新日期：2018-03-01 00:00:00

  • Orientia tsutsugamushi infection: overview and immune responses.

    abstract：:Orientia tsutsugamushi, an obligate intracellular bacterium, was isolated for the first time in 1930. Infections by virulent strains are characterized by fever, rash, eschar, pneumonia, myocarditis, and disseminated intravascular coagulation. Here we review the general aspects of O. tsutsugamushi and immune responses ...

    journal_title：Microbes and infection

    pub_type： 杂志文章,评审

    doi：10.1016/s1286-4579(00)01352-6

    authors： Seong SY,Choi MS,Kim IS

    更新日期：2001-01-01 00:00:00

  • Experimental Trypanosoma cruzi infection alters the shaping of the central and peripheral T-cell repertoire.

    abstract：:We investigated the thymic and peripheral T-lymphocyte subsets in BALB/c mice undergoing acute or chronic Trypanosoma cruzi infection, in terms of expression of particular Vbeta rearrangements of the T-cell receptor. We first confirmed the severe depletion of CD4(+)CD8(+) thymocytes following acute T. cruzi infection....

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/s1286-4579(03)00156-4

    authors： Mendes-da-Cruz DA,de Meis J,Cotta-de-Almeida V,Savino W

    更新日期：2003-08-01 00:00:00

  • Cross-reactivity analysis of T cell receptors specific for overlapping HIV-1 Nef epitopes of different lengths.

    abstract：:Overlapping peptides of different lengths from a certain immunodominant region can be presented by the same HLA class I molecule and elicit different T cell responses. However, how peptide-length specificity of antigen-specific CD8(+) T lymphocytes influence cross-reactivity profiles of these cells remains elusive. Th...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2013.12.005

    authors： Motozono C,Yokoyama M,Sato H,Ueno T

    更新日期：2014-04-01 00:00:00

  • TNF-alpha, H2O2 and NO response of peritoneal macrophages to Yersinia enterocolitica O:3 derivatives.

    abstract：:In this study, the effect of Yersinia derivatives on nitric oxide (NO), hydrogen peroxide (H2O2) and tumor necrosis factor-alpha (TNF-alpha) production by murine peritoneal macrophages was investigated. Addition of lipopolysaccharide (LPS) to the macrophage culture resulted in NO production that was dose dependent. On...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2003.10.012

    authors： Carlos IZ,Silva Monnazzi LG,Falcão DP,Machado de Medeiros BM

    更新日期：2004-02-01 00:00:00

  • Leishmania tropica in the black rat (Rattus rattus): persistence and transmission from asymptomatic host to sand fly vector Phlebotomus sergenti.

    abstract：:Black rats (Rattus rattus) receiving Leishmania tropica injected intradermally into the ear were studied for the persistence of parasites and infectivity to natural sand fly vector. The mammalian host, the parasite, and the vector all originated from the endemic focus of Urfa, Turkey. Rats did not develop lesions or a...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/s1286-4579(03)00046-7

    authors： Svobodová M,Votýpka J,Nicolas L,Volf P

    更新日期：2003-04-01 00:00:00

  • Chronic effects of Campylobacter infection.

    abstract：:Campylobacter jejuni is one of the most common causes of bacterial gastroenteritis and chronic sequelae, such as reactive arthritis and Guillain-Barré syndrome (GBS), are known to follow uncomplicated infections. While little is known about reactive arthritis following Campylobacter infection, our knowledge on the pat...

    journal_title：Microbes and infection

    pub_type： 杂志文章,评审

    doi：10.1016/s1286-4579(02)01553-8

    authors： Nachamkin I

    更新日期：2002-04-01 00:00:00

  • Mechanisms of the airway hyperresponsiveness induced by Strongyloides venezuelensis infection in rats: role of capsaicin-sensitive neurons.

    abstract：:Strongyloides venezuelensis migrates through the lungs and induces airway hyperresponsiveness (AHR). The present study evaluated the role of C-fibers in mediating airway inflammation and AHR after infection of rats with S. venezuelensis. Neonatal treatment with capsaicin effectively depleted sensory nerves. This was a...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2008.11.015

    authors： Ferreira CM,Pereira AT,Amaral FA,de Souza RS,Coelho FM,Souza DG,Negrão-Corrêa D,Teixeira MM

    更新日期：2009-02-01 00:00:00

  • Adherence of clinically isolated lactobacilli to human cervical cells in competition with Neisseria gonorrhoeae.

    abstract：:Lactobacilli are normal inhabitants of our microbiota and are known to protect against pathogens. Neisseria gonorrhoeae is a human specific pathogenic bacterium that colonises the urogenital tract where it causes gonorrhoea. In this study we analysed early interactions between lactobacilli and gonococci and investigat...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2008.07.032

    authors： Vielfort K,Sjölinder H,Roos S,Jonsson H,Aro H

    更新日期：2008-10-01 00:00:00

  • Regulation between survival, persistence, and elimination of intracellular mycobacteria: a nested equilibrium of delicate balances.

    abstract：:This review elaborates on recent insights gained on the dynamic aspects of interactions between pathogen and the host intracellular machinery in tuberculosis infection. In addition we will also discuss the utility of adopting a systems biology approach, both for a better understanding of TB biology, and for the develo...

    journal_title：Microbes and infection

    pub_type： 杂志文章,评审

    doi：10.1016/j.micinf.2010.10.009

    authors： Kumar D,Rao KV

    更新日期：2011-02-01 00:00:00

  • Computational modeling of TC0583 as a putative component of the Chlamydia muridarum V-type ATP synthase complex and assessment of its protective capabilities as a vaccine antigen.

    abstract：:Numerous Chlamydia trachomatis proteins have been identified as potential subunit vaccines, of which the major outer-membrane protein (MOMP) has, so far, proven the most efficacious. Recently, subunit A of the V-type ATP synthase (ATPase; TC0582) complex was shown to elicit partial protection against infection. Comput...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2015.12.002

    authors： Tifrea DF,Barta ML,Pal S,Hefty PS,de la Maza LM

    更新日期：2016-04-01 00:00:00

  • Are miRNAs critical determinants in herpes simplex virus pathogenesis?

    abstract：:miRNAs are small noncoding RNA that play a crucial role in gene regulation by inhibiting translation or promoting mRNA degradation. Viruses themselves express miRNAs that can target either the host or viral mRNA transcriptome. Moreover, viral infection of cells causes a drastic change in host miRNAs. This complex inte...

    journal_title：Microbes and infection

    pub_type： 杂志文章,评审

    doi：10.1016/j.micinf.2017.12.007

    authors： Bhela S,Rouse BT

    更新日期：2018-01-01 00:00:00

  • Toxoplasma gondii mitogen-activated protein kinases are associated with inflammasome activation in infected mice.

    abstract：:Toxoplasma gondii can activate the nucleotide-binding domain and leucine-rich repeat-containing proteins NLRP1/3 inflammasomes, which mediate host resistance to the infection. Here we showed that deletion of mitogen-activated protein kinases MAPK1 and MAPK2 of type I parasite decreases acute virulence in mice, charact...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2016.07.004

    authors： Wang S,Wang Z,Gu Y,Li Z,Li Z,Wei F,Liu Q

    更新日期：2016-11-01 00:00:00

  • A multivalent combination of experimental antituberculosis DNA vaccines based on Ag85B and regions of difference antigens.

    abstract：:Two candidate DNA vaccines based on the proteins CFP10 and CFP21 encoded by regions of difference (RDs) of Mycobacterium tuberculosis were evaluated individually and in multivalent combination with the immunodominant protein Ag85B for induction of protective immune responses against experimental tuberculosis. Experime...

    journal_title：Microbes and infection

    pub_type： 杂志文章

    doi：10.1016/j.micinf.2006.04.025

    authors： Grover A,Ahmed MF,Singh B,Verma I,Sharma P,Khuller GK

    更新日期：2006-08-01 00:00:00