Abstract:
:Toxoplasma gondii can activate the nucleotide-binding domain and leucine-rich repeat-containing proteins NLRP1/3 inflammasomes, which mediate host resistance to the infection. Here we showed that deletion of mitogen-activated protein kinases MAPK1 and MAPK2 of type I parasite decreases acute virulence in mice, characterized by low levels of interleukin (IL)-18, NLRP1/3, ASC, and caspase-1, and high levels of IL-10 and interferon (IFN)-β transcripts. Additionally, the mutants increased phosphorylation of STAT1, and decreased phosphorylation of STAT3. These findings suggest that MAPKs are associated with inflammasome activation in T. gondii-infected mice, which may contribute to new insight into the pathogenesis of T. gondii infection.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Wang S,Wang Z,Gu Y,Li Z,Li Z,Wei F,Liu Qdoi
10.1016/j.micinf.2016.07.004subject
Has Abstractpub_date
2016-11-01 00:00:00pages
696-700issue
11eissn
1286-4579issn
1769-714Xpii
S1286-4579(16)30098-3journal_volume
18pub_type
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journal_title:Microbes and infection
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journal_title:Microbes and infection
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journal_title:Microbes and infection
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journal_title:Microbes and infection
pub_type: 杂志文章
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journal_title:Microbes and infection
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journal_title:Microbes and infection
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