Abstract：
:Brucella abortus is an intracellular bacterium that establishes lifelong infections in livestock and humans although the mechanisms of its chronicity are poorly understood. Activated B cells have long lifespan and B. abortus infection activates B cells. Our results indicate that the direct infection of B cells with B. abortus induced matrix metalloproteinase-9 (MMP-9), receptor activator for NF κB ligand (RANKL), tumor necrosis factor (TNF)-α and interleukin (IL)-6 secretion. In addition, supernatants from B. abortus-infected B cells induced bone marrow-derived monocytes to undergo osteoclastogenesis. Using osteoprotegerin, RANKL's decoy receptor, we determined that RANKL is involved in osteoclastogenesis induced by supernatants from B. abortus-infected B cells. The results presented here shed light on how the interactions of B. abortus with B cells may have a role in the pathogenesis of brucellar osteoarticular disease.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Pesce Viglietti AI,Arriola Benitez PC,Giambartolomei GH,Delpino MVdoi
10.1016/j.micinf.2016.04.001subject
Has Abstractpub_date
2016-09-01 00:00:00pages
529-35issue
9eissn
1286-4579issn
1769-714Xpii
S1286-4579(16)30028-4journal_volume
18pub_type
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doi：10.1016/j.micinf.2006.03.022
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章
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