Crucial cytokine interactions in nitric oxide production induced by Mycoplasma arthritidis superantigen.


:Mycoplasma arthritidis causes autoimmune arthritis in rodents. It produces a superantigen (MAM) that simultaneously activates antigen presenting cells and T cells inducing nitric oxide and cytokine release. Nitric oxide is a key inducer and regulator of the immune system activation. Here, we investigated nitric oxide and cytokine production and interactions of these molecules in MAM-stimulated co-cultures of macrophages (J774A.1 cell line) with spleen lymphocytes. We found that: a) MAM-induced nitric oxide, interferon-gamma, membrane-associated tumor necrosis factor and interleukin-2 production in co-cultures of macrophages with lymphocytes from BALB/c and C3H/HePas but not from C57Bl/6 mice; b) production of nitric oxide was dependent on interferon-gamma whereas that of interferon-gamma was dependent on interleukin-2 and membrane-associated tumor necrosis factor; c) these cytokines up regulated MAM-induced nitric oxide production. Unraveling the mechanisms of cell activation induced by MAM might be helpful to design strategies to prevent immune system activation by superantigens and therefore in seeking amelioration of associated immunopathologies.


Microbes Infect


Microbes and infection


Shio MT,Olivier M,Jancar S,Ribeiro-Dias F




Has Abstract


2008-11-01 00:00:00














  • Activation and suppression of the proinflammatory immune response by Vibrio cholerae toxins.

    abstract::Vibrio cholerae induces either non-inflammatory diarrhea or inflammatory gastroenteritis, depending on the presence of cholera toxin, a fluid secretion inducer and a modulator of host immunity. In the absence of cholera toxin, other toxins induce inflammation, resulting in gastroenteritis. Thus, multiple toxins likely...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Satchell KJ

    更新日期:2003-11-01 00:00:00

  • Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines.

    abstract::Effective vaccines against infectious diseases and biological warfare agents remain an urgent public health priority. Studies have characterized the differentiation of effector and memory T cells and identified a subset of T cells capable of conferring enhanced protective immunity against pathogen challenge. We hypoth...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Brice GT,Dobaño C,Sedegah M,Stefaniak M,Graber NL,Campo JJ,Carucci DJ,Doolan DL

    更新日期:2007-10-01 00:00:00

  • Adaptation of human influenza H3N2 virus in a mouse pneumonitis model: insights into viral virulence, tissue tropism and host pathogenesis.

    abstract::Most pandemic influenza virus strains undergo adaptation or reassortment before they acquire the ability to cause fatal infections in a new host species. The pathologic changes and tissue tropism during virus adaptation are not fully understood. Here we investigated pathologic changes and tissue tropism by serial lung...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Narasaraju T,Sim MK,Ng HH,Phoon MC,Shanker N,Lal SK,Chow VT

    更新日期:2009-01-01 00:00:00

  • Transcriptional organization of pneumococcal psrP-secY2A2 and impact of GtfA and GtfB deletion on PsrP-associated virulence properties.

    abstract::Pneumococcal serine-rich repeat protein (PsrP) is a glycoprotein that mediates Streptococcus pneumoniae attachment to lung cells and promotes biofilm formation. Herein, we investigated the transcriptional organization of psrP-secY2A2, the 37-kbp pathogenicity island encoding PsrP and its accessory genes. PCR amplifica...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Lizcano A,Akula Suresh Babu R,Shenoy AT,Saville AM,Kumar N,D'Mello A,Hinojosa CA,Gilley RP,Segovia J,Mitchell TJ,Tettelin H,Orihuela CJ

    更新日期:2017-06-01 00:00:00

  • B-1 cells upregulate CD8 T lymphocytes and increase proinflammatory cytokines serum levels in oral encephalitozoonosis.

    abstract::Microsporidia are intracellular pathogens that cause severe disease in immunocompromised humans and animals. We recently demonstrated that XID mice are more susceptible to Encephalitozoon cuniculi infection by intraperitoneal route, evidencing the role of B-1 cells in resistance against infection. The present study in...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Langanke Dos Santos D,Alvares-Saraiva AM,Xavier JG,Spadacci-Morena DD,Peres GB,Dell'Armelina Rocha PR,Perez EC,Lallo MA

    更新日期:2018-03-01 00:00:00

  • Antineutrophil cytoplasmic antibodies directed against bactericidal/permeability-increasing protein detected in children with cystic fibrosis inhibit neutrophil-mediated killing of Pseudomonas aeruginosa.

    abstract::Antineutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability-increasing protein (BPI) were repeatedly found in cystic fibrosis (CF) patients. We analyzed the effect of BPI-ANCA in inhibiting neutrophil-mediated killing of Pseudomonas aeruginosa. The bactericidal effect expressed as percentag...

    journal_title:Microbes and infection

    pub_type: 信件


    authors: Sedivá A,Bartůnková J,Bartosová J,Jennette C,Falk RJ,Jethwa HS

    更新日期:2003-01-01 00:00:00

  • Actinobacillus actinomycetemcomitans-induced periodontal disease in mice: patterns of cytokine, chemokine, and chemokine receptor expression and leukocyte migration.

    abstract::Although the pathogenesis of periodontal disease (PD) is not well known, cytokines, chemotactic factors and inflammatory cells are certainly involved in the disease outcome. Here, we characterized the evolution of the PD induced by Actinobacillus actinomycetemcomitans in mice, showing that oral inoculation of these ba...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Garlet GP,Avila-Campos MJ,Milanezi CM,Ferreira BR,Silva JS

    更新日期:2005-04-01 00:00:00

  • Effect of the mouse Nramp1 genotype on the expression of IFN-gamma gene in early response to Salmonella infection.

    abstract::The early interferon-gamma (IFN-gamma) response after Salmonella infection was compared in resistant and susceptible congenic mice strains differing by the allele of Nramp1. IFN-gamma gene expression in vivo was studied by quantitative reverse transcription-PCR performed from the spleen of mice challenged by Salmonell...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Lalmanach AC,Montagne A,Menanteau P,Lantier F

    更新日期:2001-07-01 00:00:00

  • Composition of the bacterial flora in tonsilloliths.

    abstract::Tonsilloliths are a potential cause of oral malodor. In this study, microbial profiles and composition of tonsilloliths were determined using culture-independent molecular methods and scanning electron microscopy. 16S ribosomal RNA bacterial genes (16S rDNAs) isolated from tonsilloliths of 6 individuals were amplified...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Tsuneishi M,Yamamoto T,Kokeguchi S,Tamaki N,Fukui K,Watanabe T

    更新日期:2006-08-01 00:00:00

  • MHC-dependent survival of naïve T cells? A complicated answer to a simple question.

    abstract::The differentiation and survival of developing alpha beta thymocytes depends on effective T-cell receptor (TCR) signaling upon recognition of self peptide/major histocompatibility complex (MHC) molecule ligands. Although this concept is uniformly accepted with regard to immature thymocytes, there are conflicting repor...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Dorfman JR,Germain RN

    更新日期:2002-04-01 00:00:00

  • Respiratory nosocomial infections in the medical intensive care unit.

    abstract::Intensive care unit (ICU)-acquired lower respiratory tract infections include acute tracheobronchitis and hospital-acquired and ventilator-associated pneumonia (VAP). Nosocomial pneumonia is the second most common hospital-acquired infection and the leading cause of death in hospital-acquired infections. The mortality...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Cavalcanti M,Valencia M,Torres A

    更新日期:2005-02-01 00:00:00

  • A working model for the type III secretion mechanism in Chlamydia.

    abstract::It has been appreciated for almost 20 years that members of the Chlamydiales possess a virulence-associated type III secretion mechanism. Given the obligate intracellular nature of these bacteria, defining exactly how type III secretion functions to promote pathogenesis has been challenging. We present a working model...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Ferrell JC,Fields KA

    更新日期:2016-02-01 00:00:00

  • In vitro and in vivo replication of seal gammaherpesviruses in cells of multiple species.

    abstract::Phocid herpesvirus virus type 2 (PhHV-2), a putative gammaherpesvirus of seals, has been isolated from harbor seals (Phoca vitulina) and grey seals (Halichoerus grypus). In the present study, different PhHV-2 isolates were shown to have a broad in vitro tropism for various cell types from several mammalian species. In...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Martina BE,Verjans GM,Kuiken T,van Amerongen G,Osterhaus AD

    更新日期:2007-01-01 00:00:00

  • Protective role of adenylate cyclase in the context of a live pertussis vaccine candidate.

    abstract::Despite high vaccination coverage, pertussis remains an important respiratory infectious disease and the least-controlled vaccine-preventable infectious disease in children. Natural infection with Bordetella pertussis is known to induce strong and long-lasting immunity that wanes later than vaccine-mediated immunity. ...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Lim A,Ng JK,Locht C,Alonso S

    更新日期:2014-01-01 00:00:00

  • Different cytokines are required for induction and maintenance of the Th2 type response in DBA/2 mice resistant to infection with Leishmania major.

    abstract::Experimental cutaneous leishmaniasis is a useful model in studying the mechanism regulating immune responses between T helper type 1 (Th1) and Th2. Mice susceptible to Leishmania major infection such as BALB/c (H-2(d)) are associated with the induction of the disease-promoting Th2 response, while the resistant mice su...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Nashed BF,Maekawa Y,Takashima M,Zhang T,Ishii K,Dainichi T,Ishikawa H,Sakai T,Hisaeda H,Himeno K

    更新日期:2000-10-01 00:00:00

  • A comparison of Anopheles gambiae and Plasmodium falciparum genetic structure over space and time.

    abstract::Population genetic structure and subdivision are key factors affecting the evolution of organisms. In this study, we analysed and compared the population genetic structure of the malaria parasite Plasmodium falciparum and its mosquito vector Anopheles gambiae over space and time in the Nianza Province, near Victoria L...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Prugnolle F,Durand P,Jacob K,Razakandrainibe F,Arnathau C,Villarreal D,Rousset F,de Meeûs T,Renaud F

    更新日期:2008-03-01 00:00:00

  • The impact of genomics on discovering drugs against infectious diseases.

    abstract::Genomics is accelerating the progress in data generation and interpretation in the global analyses of components of cells, including the spectrum of lipids, RNA, metabolites, proteins, mutational phenotypes or DNA methylation sites. Integration of the knowledge generated by these diverse strategies is predicted to hav...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Boshoff HI,Manjunatha UH

    更新日期:2006-05-01 00:00:00

  • TLR3 and TLR7 are involved in expression of IL-23 subunits while TLR3 but not TLR7 is involved in expression of IFN-beta by Theiler's virus-infected RAW264.7 cells.

    abstract::Theiler's murine encephalomyelitis virus (TMEV) infects macrophages and causes demyelinating disease (DD) in certain mouse strains. IL-23 p19/p40 and IFN-beta, which are both expressed by macrophages in response to TMEV, could contribute to or prevent DD. Because TMEV may induce macrophages' cytokines through TLR3 and...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Al-Salleeh F,Petro TM

    更新日期:2007-09-01 00:00:00

  • Cellular and molecular hemocyte responses of the Pacific oyster, Crassostrea gigas, following bacterial infection with Vibrio aestuarianus strain 01/32.

    abstract::The strategies used by bacterial pathogens to circumvent host defense mechanisms remain largely undefined in bivalve molluscs. In this study, we investigated experimentally the interactions between the Pacific oyster (Crassostrea gigas) immune system and Vibrio aestuarianus strain 01/32, a pathogenic bacterium origina...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Labreuche Y,Lambert C,Soudant P,Boulo V,Huvet A,Nicolas JL

    更新日期:2006-10-01 00:00:00

  • Characterization of a locus encoding four paralogous outer membrane lipoproteins of Brachyspira hyodysenteriae.

    abstract::The identification of Brachyspira hyodysenteriae outer membrane proteins (OMPs) that may stimulate immunity to swine dysentery is important for vaccine development. We report here the analysis of a novel locus, blpGFEA, encoding four tandem paralogous proteins of approximately 30 kDa from B. hyodysenteriae. The four p...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Cullen PA,Coutts SA,Cordwell SJ,Bulach DM,Adler B

    更新日期:2003-04-01 00:00:00

  • WITHDRAWN: Corrigendum to: "Natural death of adult Onchocerca volvulus and filaricidal effects of doxycycline induce local FOXP3+/CD4+ regulatory T cells and granzyme expression" [Microbes Infect 10 (2008) 313-324].

    abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at ...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Korten S,Badusche M,Büttner DW,Hoerauf A,Brattig N,Fleischer B

    更新日期:2008-04-16 00:00:00

  • Pathophysiological functions of the CagA oncoprotein during infection by Helicobacter pylori.

    abstract::Infection with Helicobacter pylori cagA-positive strains plays an essential role in the development of gastric carcinoma. This review summarizes the pathophysiological functions of the cagA gene product, CagA, particularly focusing on the molecular mechanisms underlying CagA translocation into the host cells as well a...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Murata-Kamiya N

    更新日期:2011-09-01 00:00:00

  • A recombinant vesicular stomatitis virus encoding CCR5-tropic HIV-1 receptors targets HIV-1-infected cells and controls HIV-1 infection.

    abstract::Anti-retroviral therapy is useful to treat human immunodeficiency virus type 1 (HIV-1)-infected individuals, but has some major problems, such as the generation of multidrug-resistant viruses. To develop a novel supplemental or alternative therapeutic for CCR5-tropic (R5) HIV-1 infection, we generated a recombinant ve...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Okuma K,Fukagawa K,Kohma T,Takahama Y,Hamaguchi Y,Ito M,Tanaka Y,Buonocore L,Rose JK,Hamaguchi I

    更新日期:2017-01-01 00:00:00

  • The role of interleukin 15 in mounting an immune response against microbial infections.

    abstract::Interleukin (IL)-15 is a recently described cytokine that resembles IL-2 in its biological activities, stimulating natural killer cells, T cells and B cells to proliferate, secrete cytokines, and exhibit increased cytotoxicities or produce antibody. IL-15 also exerts unique functions such as stimulation of phagocytes,...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Yoshikai Y,Nishimura H

    更新日期:2000-04-01 00:00:00

  • Current studies on the pathogenesis of melioidosis.

    abstract::Burkholderia pseudomallei is a major cause of bacterial septicemias in many parts of the world, particularly Thailand; the known geographic range of the organism appears to be enlarging as awareness of the organism and the disease it causes--melioidosis--increases. B. pseudomallei is intrinsically resistant to most an...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Woods DE,DeShazer D,Moore RA,Brett PJ,Burtnick MN,Reckseidler SL,Senkiw MD

    更新日期:1999-02-01 00:00:00

  • The overlapping host responses to bacterial cyclic dinucleotides.

    abstract::Macrophages respond to infection with Legionella pneumophila by the induction of inflammatory mediators, including type I Interferons (IFN-Is). To explore whether the bacterial second messenger cyclic 3'-5' diguanylate (c-diGMP) activates some of these mediators, macrophages were infected with L. pneumophila strains i...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Abdul-Sater AA,Grajkowski A,Erdjument-Bromage H,Plumlee C,Levi A,Schreiber MT,Lee C,Shuman H,Beaucage SL,Schindler C

    更新日期:2012-02-01 00:00:00

  • Role of Nods in bacterial infection.

    abstract::Research into intracellular sensing of microbial products is an up and coming field in innate immunity. Nod1 and Nod2 are members of the rapidly expanding family of NACHT domain-containing proteins involved in intracellular recognition of bacterial products. Nods proteins are involved in the cytosolic detection of pep...

    journal_title:Microbes and infection

    pub_type: 杂志文章,评审


    authors: Bourhis LL,Werts C

    更新日期:2007-04-01 00:00:00

  • Mechanisms of the airway hyperresponsiveness induced by Strongyloides venezuelensis infection in rats: role of capsaicin-sensitive neurons.

    abstract::Strongyloides venezuelensis migrates through the lungs and induces airway hyperresponsiveness (AHR). The present study evaluated the role of C-fibers in mediating airway inflammation and AHR after infection of rats with S. venezuelensis. Neonatal treatment with capsaicin effectively depleted sensory nerves. This was a...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Ferreira CM,Pereira AT,Amaral FA,de Souza RS,Coelho FM,Souza DG,Negrão-Corrêa D,Teixeira MM

    更新日期:2009-02-01 00:00:00

  • Repeated lipopolysaccharide (LPS) exposure inhibits HIV replication in primary human macrophages.

    abstract::Repetitive exposure of macrophages to microbial antigen is known to tolerize them to further stimulation and to inhibit proinflammatory cytokine release. Using transgenic (Tg) mice that incorporate the entire HIV-1 genome we have previously shown that toll like receptor (TLR)-2, -4, and -9 ligands induced tolerance as...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Equils O,Salehi KK,Cornateanu R,Lu D,Singh S,Whittaker K,Baldwin GC

    更新日期:2006-08-01 00:00:00

  • Assessment of cell-surface exposure and vaccinogenic potentials of Treponema pallidum candidate outer membrane proteins.

    abstract::Syphilis, a sexually transmitted infection caused by the spirochetal bacterium Treponema pallidum, remains a global public health problem. T. pallidum is believed to be an extracellular pathogen and, as such, the identification of T. pallidum outer membrane proteins that could serve as targets for opsonic or bacterici...

    journal_title:Microbes and infection

    pub_type: 杂志文章


    authors: Tomson FL,Conley PG,Norgard MV,Hagman KE

    更新日期:2007-09-01 00:00:00