Crucial cytokine interactions in nitric oxide production induced by Mycoplasma arthritidis superantigen.

Abstract:

:Mycoplasma arthritidis causes autoimmune arthritis in rodents. It produces a superantigen (MAM) that simultaneously activates antigen presenting cells and T cells inducing nitric oxide and cytokine release. Nitric oxide is a key inducer and regulator of the immune system activation. Here, we investigated nitric oxide and cytokine production and interactions of these molecules in MAM-stimulated co-cultures of macrophages (J774A.1 cell line) with spleen lymphocytes. We found that: a) MAM-induced nitric oxide, interferon-gamma, membrane-associated tumor necrosis factor and interleukin-2 production in co-cultures of macrophages with lymphocytes from BALB/c and C3H/HePas but not from C57Bl/6 mice; b) production of nitric oxide was dependent on interferon-gamma whereas that of interferon-gamma was dependent on interleukin-2 and membrane-associated tumor necrosis factor; c) these cytokines up regulated MAM-induced nitric oxide production. Unraveling the mechanisms of cell activation induced by MAM might be helpful to design strategies to prevent immune system activation by superantigens and therefore in seeking amelioration of associated immunopathologies.

journal_name

Microbes Infect

journal_title

Microbes and infection

authors

Shio MT,Olivier M,Jancar S,Ribeiro-Dias F

doi

10.1016/j.micinf.2008.09.010

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

1543-51

issue

14-15

eissn

1286-4579

issn

1769-714X

pii

S1286-4579(08)00264-5

journal_volume

10

pub_type

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