Abstract：
:Mycoplasma arthritidis causes autoimmune arthritis in rodents. It produces a superantigen (MAM) that simultaneously activates antigen presenting cells and T cells inducing nitric oxide and cytokine release. Nitric oxide is a key inducer and regulator of the immune system activation. Here, we investigated nitric oxide and cytokine production and interactions of these molecules in MAM-stimulated co-cultures of macrophages (J774A.1 cell line) with spleen lymphocytes. We found that: a) MAM-induced nitric oxide, interferon-gamma, membrane-associated tumor necrosis factor and interleukin-2 production in co-cultures of macrophages with lymphocytes from BALB/c and C3H/HePas but not from C57Bl/6 mice; b) production of nitric oxide was dependent on interferon-gamma whereas that of interferon-gamma was dependent on interleukin-2 and membrane-associated tumor necrosis factor; c) these cytokines up regulated MAM-induced nitric oxide production. Unraveling the mechanisms of cell activation induced by MAM might be helpful to design strategies to prevent immune system activation by superantigens and therefore in seeking amelioration of associated immunopathologies.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Shio MT,Olivier M,Jancar S,Ribeiro-Dias Fdoi
10.1016/j.micinf.2008.09.010subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1543-51issue
14-15eissn
1286-4579issn
1769-714Xpii
S1286-4579(08)00264-5journal_volume
10pub_type
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2001-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2011-09-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.12.001
更新日期：2005-02-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)00031-x
更新日期：2002-12-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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更新日期：2002-07-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.04.009
更新日期：2007-07-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Microbes and infection
pub_type： 信件
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journal_title：Microbes and infection
pub_type： 杂志文章
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更新日期：2005-03-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
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更新日期：2002-11-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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更新日期：2000-02-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
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更新日期：2006-07-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.07.009
更新日期：2008-07-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.02.011
更新日期：2006-06-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)00005-9
更新日期：2002-11-01 00:00:00
