Abstract:
:To identify immunodominant antigens and MHC-restricted antibody responses, seven different strains of mice were intravaginally infected with Chlamydia muridarum and compared for antibody responses to 257 C. muridarum proteins. The 7 strains of mice recognized a total of 109 proteins as antigens, of which, 5 antigens (TC0660, TC0727, TC0828, TC0726 & TC0268) were each recognized by 60% or more mice from each mouse strain and thus designated as immunodominant antigens. Furthermore, antibody responses to 19 other antigens displayed strong associations with mouse H-2 haplotypes, including 6 antigens (TC0480, TC0912, TC0229, TCA04, TC0289 & TC0892) whose antibody responses were linked to H-2(b), 8 (TC0035, TC0387, TC0052, TC0781, TC0373, TC0117, TC0066 & TC0396) to H-2(d) and 5 (TC0512, TC0177, TC0589, TC0794 & TC0596) to H-2(k) haplotypes respectively. Interestingly, H-2(b) was negatively associated with antibody responses to most of the antigens that were positively linked to H-2(d) or H-2(k) haplotypes. These results by mapping Chlamydia trachomatis antigens commonly recognized by mice with different strain background and H-2 genes and revealing antigen association with H-2 haplotypes have provided important information for developing chlamydial subunit vaccines and understanding chlamydial pathogenesis.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Zeng H,Hou S,Gong S,Dong X,Zou Q,Zhong Gdoi
10.1016/j.micinf.2012.02.005subject
Has Abstractpub_date
2012-07-01 00:00:00pages
659-65issue
7-8eissn
1286-4579issn
1769-714Xpii
S1286-4579(12)00048-2journal_volume
14pub_type
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journal_title:Microbes and infection
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journal_title:Microbes and infection
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journal_title:Microbes and infection
pub_type: 杂志文章
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2004.11.005
更新日期:2005-03-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
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journal_title:Microbes and infection
pub_type: 杂志文章
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journal_title:Microbes and infection
pub_type: 杂志文章
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.02.011
更新日期:2006-06-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2013.06.006
更新日期:2013-09-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2004.04.011
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journal_title:Microbes and infection
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journal_title:Microbes and infection
pub_type: 信件
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pub_type: 杂志文章,评审
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journal_title:Microbes and infection
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journal_title:Microbes and infection
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journal_title:Microbes and infection
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doi:10.1016/j.micinf.2005.10.007
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journal_title:Microbes and infection
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2007.10.002
更新日期:2008-01-01 00:00:00
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journal_title:Microbes and infection
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doi:10.1016/j.micinf.2009.03.001
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